Journal of Craniomaxillofacial Research 2016. 3(2):185-190.

Association between the serotonin- transporter- linked polymorphic region (5-HTTLPR) and pemphigous disease in Iranian patients
Shamsolmolok Najafi, Nafiseh Esmaili, Mansour Heidari, Farahnaz Ghassemi, Meisam Mahmoudi, Mahsa Mohammadzadeh, Abdolreza Mohamadnia, Naghmeh Bahrami

Abstract


Introduction: Pemphigus vulgaris (PV) is a relatively rare autoimmune disease characterized by blistering of the skin and mucosa. The main objective of this study was to investigate the possible association between the 5-HTTLPR polymorphism and PV in Iranian patients. For this, 112 PV and 100 controls were enrolled in this study.
Materials and Methods: In this case-control study, Genomic DNA was extracted from whole blood and genotyping of all participants for the 5-HTTLPR polymorphism was carried out using the polymerase chain reaction (PCR) technique. The genotypes were grouped into three
classes: homozygous for the short allele (SS), heterozygous for the short and long allele (LS) and homozygous for the long allele (LL).
Results: Our results showed no significant association between the 5-HTTLPR polymorphism genotypes, LL, SS and LS in PV patients compared to controls. Also, our finding did not reveal any evidence of an association between this disease and the allele frequency of S and L. Taken together, our findings suggested that the 5-HTTLPR polymorphism is unlikely to be a factor contributing to the risk of developing pemphigus vulgaris.
Conclusion: It can be concluded that although 5-HTTLPR polymorphism seems to be associated with some of auto-immune and stress-related disease.
Key words: Iranian Population, PCR, Pemphigus vulgaris, Polymorphism, Risk Factor.

Keywords


Iranian Population; PCR; Pemphigus vulgaris; Polymorphism; Risk Factor

Full Text:

PDF

References


Veldman C, Feliciani C. Pemphigus: A Complex T Cell-dependent Autoimmune Disorder Leading to Acantholysis. Clinic Rev Allerg Immunol. 2008;34: 313–320.

Scully C, Challacombe SJ. Pemphigus vulgaris:up- date on ethipathogenesis, ora manifestations,and management. Oral Manifestations, and Manage- ment.CROBM. 2002; 13(5): 397-408.

Thorat MS, Raju A, R.Pradeep A. Pemphigus vul- garis:effects on periodontal health. Journal of Oral Science. 2010; 52(3): 449-454.

Chams-Davatchi C, Valikhani M, Daneshpazhooh M,Esmaili N, Hallaj Z, Barzegari M, Akhiani M, Ghodsi Z, Mortazavi H, Naraghi Z. Pemphigus: Analysis of 1219cases. International Journal of Dermatology. 2014; 53:531-553.[5] Burket LAW, Greenberg MS, Glick M. Vesicular and Bullous Lesion. Burketʼs Oral Medicine . 11th ed. United states: Bc Decker. 2003; 211-232.

Shirakata Y, Amagai M, Hanakawa Y, Nishikawa T, Hashimoto K. Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1. Journal of Investigative Derma- tology. 1998; 110: 76–78.

Asilian A, Yoosefi A, Faghini G. Pemphigus vul- garis in Iran: epidemiology and clinical profile. SKINmed: Dermatology for the Clinician . 2006 March/April; 5(2): 9–71.

Brenner S, Ruocco V, Bialy-Golan A, et al. Drug-in- duced pemphigus. Clinics in dermatology. 2011;39: 313-393.

Shapiro M, Jimenez S, Werth VP . Pemphigus vul- garis induced by D-penicillamine therapy in a pa- tient with systemic sclerosis. J Am Acad Dermatol.2000 Feb; 42:297-9

Wolf R, Brenner S. An active amide group in the molecule of drugs that induce pemphigus: a casual or causal relationship?. Dermatology .1994;189:1–4.

Goldberg I, Kashman Y, Brenner S. The induc- tion of pemphigus by phenol drugs. Interna- tional Journal of Dermatology. 1999 December;38(12): 888–892.

Gange R.W., Rhodes E.L., Edwards C.O., Powell M.E. A. Pemphigus induced by rifampicin. British Journal of Dermatology. October 1976; 95(4):445- 448.

Matz H, Bialy-Golan A, Brenner S. Diclofenac: a new trigger of pemphigus vulgaris?. Dermatology .1997; 195:48–49.

Ong CS, Cook N, Lee S. Drug-related pemphigus and angiotensin converting enzyme inhibitors. Australasian journal of dermatology. 2000 No- vamber; 41(4):242-246.

Bastuji-Garin S, Turki H, Mokhtar I, Nouira R, Fazaa B, Jomaa B, et al. Possible relation of Tu- nisian pemphigus with traditional cosmetics: A Multicenter case-control study. American Journal of Epidemiology. 2001; 155(3): 249-256.

Brenner S, Tur E., Shapiro J, Ruocco V, D’Avino M, Ruocco E,et al. Pemphigus vulgaris: environ- mental factors.Occupational, behavioral, medical, and qualitative food frequency questionnaire. In- ternational Journal of Dermatology. 2001 Sep- tember; 40(9): 562-569.

Kimayi-Asadi A , Usman A. The role of psycho- logical stress in skin disease. Journal of Cutaneous Medicine and Surgery. 2001; 4(2):140-145.

Morell-Dubois S, Carpentier O, Cottencin O, Queyrel V, Hachulla E. Stressful life Events and Pemphigus. Dermatology. Dermatology .2008;216(2):104-108.

Victoria JMN, Fátima CS, Flávio JP, Kalapothakis E, Gomez RS. Serotonin transporter gene poly- morphism (5-HTTLPR) in patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. 2005 September; 34(8): 494-497.

Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Sci- ence magazine. 1996 November; 274: 1527-1531.

Greenberg B.D, Li Q, Lucas FR, et al. Associa- tion between the serotonin transporter promoter polymorphism and personality traits in a primar- ily female populations sample. American Journal Of Medical Genetics. 2000 April; 96 (2): 202-216.

Lesch K.P, Balling U, Gross J, et al. Organization of the human serotonin transporter gene. Journal Of Neural Transmission. 1994; 95: 157–162

Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS. Antidepressant and cocaine sensitive human serotonin transporter: localization molecular cloning, expression and chromosomal localization. Proc Natl Acad Sci U S A. 1993 Mar 15; 90 (6):2542-6.

Heils A, Teufel A, Petri S, et al. Allelic variation of human serotonin transporter gene expression. Journal Of Neurochemistry. 1996 June; 66 (6):2621-2624.

Caspi A, sugden A, E. Moffitt t, et al. Influence of Life Stress on Depression: Moderation by a Poly- morphism in the 5-HTT Gene. Science. 2003 Jul 18; 301 (5631):386-9.

C. Cividanes G, F. Mello A, M. Sallum J, et al. Lack of association between the 5-HTTLPR and positive screening for mental disorders amongchildren exposed to urban violence and maltreat ment. Revista Brasileira de Psiquiatria. 2014; 36:277–284.

Kendler KS, Kuhn JW, Vittum J, Prescott CA, Ri- ley B. The interaction of stressful life events and a serotonin transporter polymorphism in the pre- diction of episodes of major depression: A replica- tion. Arch Gen Psychiatry. 2005; 62:529-35.

Eley TC, Sugden K, Corsico A, Gregory AM, Sham P, McGuffin P, et al. Gene-environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry.2004; 9:908-915.

Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE.Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implica tions for studying complex diseases and traits. Am Psychiatric Assoc. 2010 Summer; 8(3):398-416.

Srijan Sen, Margit Burmeister, Debashis Ghosh.Meta-Analysis of the Association Between a Se- rotonin Transporter Promoter Polymorphism (5-HTTLPR) and Anxiety-Related Personality Traits. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2004 May; 127B (1): 85-89.

Natan A. Gillespie, John B. Whitfield, Ben Wil- iams. The elationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychological Medicine. 2005; 35(1):101–111.

Harman KE, Albert S, Black MM. Guidelines for the management of pemphigus vulgaris. British Journal of Dermatology. 2003; 149 (5):926–937.


Refbacks

  • There are currently no refbacks.


Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.