Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 1 3-4 2015 10 12 42 44 EN Mohammad Bayat Craniomaxillofacial Research Center, Shariati Hospital and Department of Oral and Maxillofacial Surgery, Dental School, Tehran University of Medical Sciences, Tehran, Iran Majid Beshkar Craniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran 2015 10 12 2015 10 12 Introduction: Surgical repair of cleft palate with a bony bridge may offer some distinct advantages including a lower rate of fistula formation. The goal of this study was to evaluate the feasibility of surgically inducing cleft palate and reconstruction of the cleft with the use of bone morphogenetic protein-2 (BMP-2) in sheep. Materials and Methods: In the control group (two sheep), the cleft palate was repaired with standard von Langenbeck technique. In the study group (two sheep), the cleft was repaired with the same technique with the exception that aBMP-2 gel was placed between the two oral and nasal layers. Two months after cleft repair surgery,  animals were sacrificed and  the cleft sites  were evaluated histologically with the use of light microscopy. Results: The results showed that surgically inducing cleft palate and repairing the  cleft  is  feasible  in  sheep.  Microscopic  evaluation  showed  no  bone formation in control group and minor bone formation in the study group. Conclusion: To determine whether BMP-2 is a useful adjunct to standard cleft palate repair techniques, an animal study with larger population is required. https://jcr.tums.ac.ir/index.php/jcr/article/view/13 https://jcr.tums.ac.ir/index.php/jcr/article/download/13/58