Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 4 2 2017 07 22 377 382 EN Mozhgan Kazemian Oral and maxillofacial surgery,Oral and Maxillofacial Diseases Research Center, Mashhad University Of Medical Sciences, Mashhad, Iran. Farnoosh Razmara Craniomaxillofacial Research center, Tehran University of Medical Sciences, Tehran, Iran. Oral and Maxillofacial Surgery Department, School of Dentistry,Tehran University of Medical Sciences, Tehran, Iran. Nafiseh Ghadiri Moghadam Dentist. 2017 07 22 2017 07 22 Introduction: Ectodermal dysplasia (ED) is a group of syndromes and disorders in the human body characterized by structural anomalies in the ectoderm and often associated with hair, teeth and skin abnormalities. There are many syndromes associated with ED. Case report: Here is a case report of two young patients with different manifestations of ectodermal dysplasia. Conclusion: One patient was diagnosed as Rapp-Hodgkin syndrome and the other as Hypohidrotic ectodermal dysplasia, according to clinical findings. Key words: Ectodermal dysplasia, Hypodontia, Hypohydrotia. https://jcr.tums.ac.ir/index.php/jcr/article/view/159 https://jcr.tums.ac.ir/index.php/jcr/article/download/159/182