Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 2 1-2 2015 10 13 69 73 EN Mohammad Bayat Craniomaxillofacial Research Center, Shariati Hospital and Department of Oral and Maxillofacial Surgery, Dental School, Tehran University of Medical Sciences, Tehran, Iran Simin Zahra-Mohebbi Community Oral Health Department, School of Dentistry, Tehran University of Medical Sciences Amir Jalal Abbasi Craniomaxillofacial Research Center, Shariati Hospital and Department of Oral and Maxillofacial Surgery, Dental School, Tehran.University of Medical Sciences, Tehran, Iran Maedeh Bonabi Community Oral Health Department, School of Dentistry, Tehran University of Medical Sciences 2015 10 12 2015 10 12 Craniofacial  anomalies  include  clefts,  synostoses,  atrophic  abnormalities,neoplasias etc. among which cleft lip and/or palate caused by abnormal facial development during gestation is one of the most prevalent congenital defects. Its overall occurrence is about 1:700 ranging from 0.02 to 4.04 in 1000 live births. There are different etiologic factors considering the cleft cause. In most cases the exact cause is unknown, but it is thought to be a combination of genetic (internal) and environmental (external) factors.A cleft lip and palate can have a profound psychological impact both on the parents  and  the  child.  It  affects  the  appearance of  the  face,  also  lead  to problems  with  feeding,  speech  and  language  and  hearing  –due  to  ear infections. Speech and aesthetic concerns seem to have been important factors affecting the health-related quality of life for children with oral clefts. It is obvious that cleft lip and palate can have a substantial impact on the health economics of countries in the developing world.The  multispecialty approach  to  the  care  of  children  with  clefts  is  highly recommended.  A  research  registry  can  be  of  invaluable  assistance  to physicians and researchers by providing an available panel of patient information that could assist in understanding the patients they are serving, utilization  of  health  care  services,  and  the  design  and  implementation of research studies to improve patient care.The Cleft Lip/Palate and Craniofacial Anomalies Registry may be functioning with a mission “to promote better understanding of cleft lip/palate and craniofacial anomalies and to improve patient care and health care planning. Data collection can provide better resources for future interventional studies. As it helps to have an accurate picture of the children’s number in need of treatment in a population. Recording the data of cleft patients and treatment teams and their workload is necessary for planning about providing training centers for members of treatment teams. https://jcr.tums.ac.ir/index.php/jcr/article/view/19 https://jcr.tums.ac.ir/index.php/jcr/article/download/19/64