Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 4 4 2017 12 10 457 460 EN Fereshteh Baghai Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences and Department of oral & maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Sedigheh Rahrotaban Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Science, Tehran, Iran. Ata Garajei Department of Oral and Maxillofacial Surgery, School of Dentistry, and Department of Head and Neck Surgical Oncology and Reconstructive Surgery, The Cancer Institute, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Fatemeh Pirzadeh Dental student. Samira Derakhshan Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Science, Tehran, Iran. 2017 12 10 2017 12 10 Malignant melanoma is an aggressive malignancy of melanocytes affecting both skin and mucosa. Primary oral melanoma occurs 0.2-8% of all melanomas and accounts for 0.5% of all oral malignancies. Oral mucosal melanoma is different from cutaneous melanoma because of different etiology, genetic alteration and prognosis. We present a case of primary mucosal melanoma in a 33 years old man with the previous report of peripheral giant cell granuloma in the same site. The patient died less than one year because of numerous distant metastases. We suggest early diagnosis of oral melanoma can improve survival rate of the patients such as other primary oral malignancy. https://jcr.tums.ac.ir/index.php/jcr/article/view/191 https://jcr.tums.ac.ir/index.php/jcr/article/download/191/203