Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 5 1 2018 04 22 50 53 EN Mohsen Barzegar Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Adele Pouyafard Department of Oral Medicine, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Seyed Hosein Tabatabaei Department of Oral and Maxillofacial Pathology, Social Determinants of Oral Health Research Center, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Alireza Navabazam Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Hamidreza Ajami Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mehdi Chohedri Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2018 04 21 2018 04 21 Pyogenic granuloma is a common tumor-like growth of the oral cavity that traditionally has been considered to be non-neoplastic in nature. The pyogenic granuloma is a smooth or lobulated mass that is usually pedunculated, although some lesions are sessile. Pyogenic granuloma of the gingival is frequently developed in pregnant women, hence the terms pregnancy tumor and/or granuloma gravidarum are often used. The pyogenic granuloma has been reported to be associated with port-wine stain particularly during pregnancy, and after trauma, or laser treatment. The  pathogenesis of pyogenic granuloma is unclear. This report describes the presentation of a large pregnancy tumor in a patient with an isolated facial port-wine stain. Keywords: Port-wine stain, Pregnancy, Pyogenic granuloma. https://jcr.tums.ac.ir/index.php/jcr/article/view/212 https://jcr.tums.ac.ir/index.php/jcr/article/download/212/222