Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 6 1 2019 08 24 34 38 Maryam Masoum Khani Department of Cell and Molecular Biology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran. Abdolreza Mohamadnia Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Farzaneh Hosseini Department of Microbiology, North Tehran Branch, Islamic Azad University, Tehran, Iran. Parisa Bayat Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran. Naghmeh Bahrami Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran 2019 07 23 2019 07 26 Introduction: Oral squamous cell carcinoma accounts for 2% of all cancers and also is one of  the top 10 causes of death in humans. The goal of this article is to assess changes of VEGF mRNA and miR-494 expression. Materials and Methods: We chose 30 patients with OSCC and 30 healthy people (as a controlled group) and assess the rate of VEGF mRNA and miR-494 expression in peripheral blood with real-time PCR technique. Findings: VEGF mRNA marker was positive in 24 out of 30 patients. Also, miR-494 was positive in 20 out of 30 patients. Results: Overall based on this article’s findings, results could count as a diagnostic screening test for OSCC  detection in early steps of cancer. https://jcr.tums.ac.ir/index.php/jcr/article/view/290 https://jcr.tums.ac.ir/index.php/jcr/article/download/290/260