Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 6 3 2020 02 08 132 137 Nazanin Mahdavi Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Hoorieh Bashizadeh Department of Dentomaxillofacial Radiology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Samira Derakhshan Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Younes Ghoreyshi School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. 2019 10 12 2019 12 09 Carcinoma as a primary tumor within the jaw is a rare phenomenon which usually arises from the epithelial lining of oral cavity or salivary glands. Primary intraosseous squamous cell carcinoma is a malignant neoplasm with no initial connection to oral mucosa. In this article, we reported two rare cases of primary intra-mandibular squamous cell carcinoma with clinical, radiographic, and histopathologic features and reviewed the literature. Keywords: Oral cancer; Squamous cell carcinoma; Malignancy. https://jcr.tums.ac.ir/index.php/jcr/article/view/300 https://jcr.tums.ac.ir/index.php/jcr/article/download/300/274