Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 6 4 2020 05 16 175 178 EN Farnoosh Razmara Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Nima Dehghani Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Xaniar Mahmoudi School of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Reza Reshadi School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Mahdi Mohammadi School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. 2020 03 05 2020 04 23 Background: Lipoma is a rare benign tumor that overgrows in oral cavity. Its occurrence rate  is about 1-4% with predilection for males rather than females. Lipoma is associated with adipose  tissue and is usually seen in major salivary glands, buccal mucosa, and vestibule. Fifty percent of  lesions are seen in buccal mucosa. The progressive and aggressive growth of these lesions may interfere  with speech and mastication owing to the dimensions and location of the tumor. The lesion  basically affects the individuals of 4th to 5th decades. Lipoma is managed by surgical excision using  scalpel, laser, or electro-cautery.  Case Presentation: This study presents two 63 and 18 years old male patients with lipoma  in their buccal mucosa along with their improved situation following the treatment. The treatment  included surgical excision of the lesion and suturing the surgical area.  Conclusions: The incidence of intraoral lipoma is low and buccal mucosa is the most common  region for the occurrence of oral lipoma. Most clinicians suggested surgical techniques as a certain  treatment.  Keywords: Lipoma; Intraoral lipoma; Soft tissue tumor; Mouth; Intraoral neoplasm; Adipose tissue. https://jcr.tums.ac.ir/index.php/jcr/article/view/312 https://jcr.tums.ac.ir/index.php/jcr/article/download/312/281