Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 7 3 2020 12 26 110 125 Mina Khayamzadeh Department of Oral and Maxillofacial Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran. Paniz Ahmadi Private Practice. Farnoosh Razmara Department of Oral and Maxillofacial Surgery, Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran. Keyhan Safavi Private Practice. 2020 09 27 2020 11 13 Aims: Temporomandibular disorders (TMD) are one of the most prevalent disorders in maxillofacial area. Due to lack of understanding of the etiology or pathogenesis of TMD and a definitive diagnostic or therapeutic approach, patients have to tolerate symptoms such as pain. This study was aimed to perform a review of non-surgical treatment methods for TMD. Materials and Methods: In this review, Google, Google Scholar, PubMed, SID, ISI Web of Science, SID and IranMedex databases were searched using key terms: temporomandibular disorders, temporomandibular joint, temporomandibular pain, non-surgical treatment. Articles meeting the inclusion criteria were recruited in the study. Finally, a total of 63 prospective clinical trials were evaluated from 2015 to 2020. Results: From the 61 studies evaluated, 27 studies were on low-level laser therapy (LLLT), 13 studies on transcutaneous electrical nerve stimulation (TENS), 5 studies on acupuncture and dry needling, 1 study on laser acupuncture, 9 studies on platelet-rich plasma (PRP) and 6 studies on Botox injection. Conclusion: Laser acupuncture had similar treatment effects in reducing pain to TENS, low-level laser, acupuncture and dry needling. It seems that the use of laser acupuncture is safer than other methods in decreasing pain of patients with TMD. https://jcr.tums.ac.ir/index.php/jcr/article/view/344 https://jcr.tums.ac.ir/index.php/jcr/article/download/344/298