Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 7 4 2021 02 21 228 231 Syeda Hala Raza Department of Oral and Maxillofacial Surgery, Karachi Medical, Dental College, Abbasi Shaheed Hospital, Karachi, Pakistan. Babar Aman Department of Oral and Maxillofacial Surgery, Karachi Medical, Dental College, Abbasi Shaheed Hospital, Karachi, Pakistan. Sufyan Ahmed Department of Oral and Maxillofacial Surgery, Karachi Medical, Dental College, Abbasi Shaheed Hospital, Karachi, Pakistan. 2020 10 21 2020 11 03 Lipoma a benign mesenchymal tumor is a rare finding in the oral cavity. This paper reports a case of 75 years old male patient with a huge lipoma of the floor of the mouth, along with its management at the Department of Maxillofacial surgery at Abbasi Shaheed Hospital, Karachi Pakistan. Conclusion: Lipoma of the floor of the mouth is very rare. We endorse complete surgical excision as an optimal treatment of oral lipoma. Keywords: Lipoma; Mesenchymal tumor; Floor of the mouth (FOM). https://jcr.tums.ac.ir/index.php/jcr/article/view/348 https://jcr.tums.ac.ir/index.php/jcr/article/download/348/313