Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 8 1 2021 07 07 16 21 Mohammad Bayat Department of Oral and Maxillofacial Surgery, Craniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Amir Mohammad Arabi Department of Oral and Maxillofacial Surgery, Craniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Amir Ali Assadi Department of Oral and Maxillofacial Surgery, Craniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Saina Nezami Nia Department of Oral and Maxillofacial Surgery, Craniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Masoud Mortezazadeh Department of Internal Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Abdolreza Mohamadnia Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Naghmeh Bahrami Department of Oral and Maxillofacial Surgery, Craniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2021 03 15 2021 04 18 Background: Nowadays COVID-19 has become a pandemic in which global society experience multiple difficulties in management. It seems that olfactory dysfunction is one of the early occurring symptoms of this viral infection and many patients just show this symptom after they got infected. Considering so, olfactory dysfunction especially a decline in olfaction could potentially be used for screening purposes and preventing the disease to spread. Materials and Methods: 50 PCR-verified SARS-CoV-2 infected participants were assessed about their olfactory function adequacy using a Modified Version of the University of Pennsylvania Smell Identification Test (UPSIT) for the Iranian population called Iran Smell Identification Test (Iran-SIT). Participants scores were compared against normal population scores in this test and possible correlations of age and scores were explored as well. Results: Participants with SARS-CoV-2 infection generally obtained lesser scores in the mentioned test which means they experience a decline in olfactory function more, significantly. Aging also has a negative correlation with olfaction adequacy. Conclusion: Based on this article’s finding, olfactory function decrease is more frequent among SARS-CoV-2 infected people and potentially could be a suggestive indicator for screening programs. This indicator should be interpreted concerning patients’ age. Keywords: COVID-19; Olfactory dysfunction; Anosmia; Early detection. https://jcr.tums.ac.ir/index.php/jcr/article/view/367 https://jcr.tums.ac.ir/index.php/jcr/article/download/367/317