Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 8 2 2021 10 02 67 75 Bayad Mahmood Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Sulaimani, Iraq. 2021 06 09 2021 08 15 Background: Facial plastic surgeries are usually associated with various post-surgical undesirable symptoms, particularly pain, Swelling, and ecchymosis. Depending on the nature of the procedures, these symptoms could last for days, sometimes over a week or more. Considering the optimal efficacy of Bromelain, this study is used to justify the benefits of pre-operative use of Bromelain found in pineapple using fresh pineapple juice to reduce such complications. Materials and Methods: A randomized clinical study was performed among 100 patients undergoing various facial surgical operations; the patients were randomly divided into two groups; fifty patients received the pre-operative fresh pineapple juice (350ml glass) twice every day, a week before and continued for seven days after surgery. The pain level was determined using a visual analog scale, Swelling, and ecchymosis judged by visual inspection. Average scores for all symptoms were added to obtain the clinical sum score for each visit. Results: Pre-operative use of fresh pineapple juice was significantly reduced post-surgical pain, swelling, and ecchymosis with statistically significant results (p<0.005) in each pineapple groups. Conclusion: Bromelain found in pineapple fruit can be used as a successful therapy before various facial surgical procedures to minimize and provide faster recovery from undesirable post-operative symptoms. Keywords: Facial surgeries; Bromelain; Pineapple juice; Wound healing; Complications. https://jcr.tums.ac.ir/index.php/jcr/article/view/375 https://jcr.tums.ac.ir/index.php/jcr/article/download/375/325