Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 8 3 2022 02 01 129 142 Bayad Mahmood Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Sulaimani, Iraq. Ibrahim Saeed Gataa Department of Oral and Maxillofacial Surgery, University of Warith Al-Anbiyaa, Iraq. Umed Mustafa Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Sulaimani, Iraq. 2021 10 12 2022 01 29 Background and Aim: Oral cancer is a major public health issue worldwide; it remains a highly lethal and disfiguring disease, it is primarily a disease of epithelial origin, it has various clinicopathological pictures. is to demonstrate various clinical and pathological presentations of oral squamous cell carcinoma in Iraqi population. Materials and Methods: A total of 80 cases of histologically diagnosed squamous cell carcinoma collected from the main centers of Sulaymaniyah teaching hospital/Hiwa cancer center Hospital/Sulaymaniyah/Iraq were analyzed according to age, sex, site, clinical, and pathological presentation of oral squamous cell carcinoma at the time of presentation, and histological grading. Results: Patients in their sixth decade of life were the most commonly affected with a male-tofemale ratio of 1.4:1. The tongue was the most frequently affected site, followed by the floor of the mouth. The most common clinical presentation is ulceration and swelling. More than 40% of the cases were well-differentiated squamous cell carcinoma. Conclusion: Oral cancer is increasingly seen as a major health problem, in line with the general trend in the region, the need for inter-professional health care delivery approaches for reducing oral cancer mortality and improving patients’ quality of life. Keywords: Squamous cell carcinoma; Oral cancer; Clinical presentation; Histopathology; Tumor grading. https://jcr.tums.ac.ir/index.php/jcr/article/view/385 https://jcr.tums.ac.ir/index.php/jcr/article/download/385/332