Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 9 1 2022 10 01 52 56 Samira Derakhshan Department of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, Tehran, Iran AND Cancer Preclinical Imaging Group, Preclinical Core Facility, Tehran University of Medical Sciences, Tehran, Iran. Monir Moradzadeh Khiavi Department of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, Tehran, Iran. Hossein Borhani Dental Student, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Narges Matloubi Department of Oral and Maxillofacial Surgery, Tehran University of Medical Sciences, Tehran, Iran. 2022 08 12 2022 09 09 Metastatic disease to the oral cavity is rare, representing only 1-8% of oral malignancies, and involvement of the mandibular ramus is even less prevalent. This report is a unique case of metastatic adenocarcinoma of the colorectal to the mandible. Clinical presentation can be quite variable, and most often a primary malignancy is already known. Jawbone metastasis are a sign of disseminated malignant neoplasms, with poor prognosis and usually an indication for palliative therapy. The requirement for arrival at an appropriate and prompt diagnosis is crucial for determining the most appropriate treatment regimens and improved outcomes. The oral metastatic lesion may be the first indication of an undiscovered distant primary tumor, making timely evaluation and treatment critical from an oncologic perspective. Here we report a known case of mucinous adenocarcinoma of colon who was referred due to a mandibular lesion. Keywords: Mandible; Mucinous adenocarcinoma; Metastasis. https://jcr.tums.ac.ir/index.php/jcr/article/view/411 https://jcr.tums.ac.ir/index.php/jcr/article/download/411/349