Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 9 3 2023 04 04 110 117 Fatemeh Abbasi Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Salman Khazaie Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran. Fatemeh Ahmadi Motamayel Dental Research Center and Dental Implant Research Center, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. 2023 01 10 2023 02 25 Introduction: Oral mucosa is one of the body’s most sensitive tissues. Due to the prevalence of oral ulcers and the effect of cancers on the oral mucosa, treating oral lesions is particularly important. Matricaria chamomilla is widely used in traditional medicine. Chamomile compounds have antibacterial، antiviral, anti-inflammatory and accelerate epithelialization. However no systematic study has been undertaken on the application of chamomile in treating oral lesions. Therefore this study aims to determine the medicinal use of chamomile in dentistry. Materials and Methods: This systematic review searched major international electronic databases, including PubMed, ISI and Scopus, from August 1998 to August 2021. The articles included in this review were clinical trials in which the participants used chamomile as a mouthwash or gel. Results: In this study, the therapeutic effects of chamomile were evaluated in 14 clinical trial studies. Most of the studies reviewed in the articles referred to the properties of flavonoid compounds with anti-inflammatory and analgesic properties of chamomile. Conclusion: Today, medicinal plants are used in treatment and one of the most common plants used for medicinal purposes is chamomile. It is used in dentistry, and its positive effects on plaque, gingivitis, caries, mucositis and its antibacterial effects have been reported. Keywords: Chamomilla; Oral mucosa; Systematic review. https://jcr.tums.ac.ir/index.php/jcr/article/view/427 https://jcr.tums.ac.ir/index.php/jcr/article/download/427/357