Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 10 1 2023 08 20 36 45 EN Mehrnoush Momeni Rouchi Department of Oral and Maxillofacial Surgery, Tehran University of Medical Sciences, Tehran, Iran. Sayna Nezaminia Department of Oral and Maxillofacial Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Narges Hajiani Department of Oral and Maxillofacial Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2023 05 03 2023 06 04 Multiple facial fractures, which involve the upper, middle, and lower thirds of the face, are called Panfacial fractures, and their management is one of the biggest challenges in the field of maxillofacial surgery. The proximity of maxillofacial skeleton to important sensory or vital structures such as the visual, olfactory, masticatory and respiratory systems and intracranial components in addition to negative effects on esthetic aspects of the face have doubled the intricacy. Small or thin fractured segments that are difficult to find and stabilize make management of pan facial fractures different from anywhere else in the body. One major challenge is to find the best pattern and sequence of treatment. There are different concepts, depending on the surgeon's experience and the pattern of fracture. This study reports three patients with the diagnosis of pan facial fractures. A 54-year-old woman, an 18-year-old and a 14-year-old man that were all victims of road traffic injuries (MVA). Conventional open reduction and internal fixation methods have been used and favorable results have been obtained in follow-up periods. https://jcr.tums.ac.ir/index.php/jcr/article/view/438 https://jcr.tums.ac.ir/index.php/jcr/article/download/438/375