Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 10 4 2024 03 03 208 211 Amir Abbasi Department of Oral and Maxillofacial Surgery, Sina Hospital, Tehran University Of Medical Sciences, Tehran, Iran; Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran. Pouyan Aminishakib Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Mani Arashrad Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran. 2024 02 13 2024 02 13 Neurofibroma is a benign tumor derived from the peripheral nerve. Most of these can be multifocal as a component of neurofibromatosis or present as a solitary tumor. Although the solitary neurofibroma is not an uncommon lesion, its intraosseous occurrence is rare, and less than 50 cases have been reported. We report a rare case of central neurofibroma, arising in the mandibular bone of 57-year-old edentulous female patient on the left side. Hemi mandibulectomy was performed and reconstructed with a reconstruction plate without any bone graft. Microscopic evaluation showed neoplastic tissue with haphazardly arranged and interlacing fascicular patterns composed of point-ended spindle-shaped tumoral cells. Immunohistochemical examination of the tumor showed positive staining for S-100 protein antibodies. Keywords: Intraosseous neurofibroma; Mandible. https://jcr.tums.ac.ir/index.php/jcr/article/view/490 https://jcr.tums.ac.ir/index.php/jcr/article/download/490/399