Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 11 2 2024 10 13 133 137 Bahareh Fattahi Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. Saeedeh Khalesi Dental Materials Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. Mohammad Reza Badi Sanaye School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. Amir Mohammad Momeni School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. 2024 02 18 2024 06 09 Crohn’s disease (CD) is a process of gastrointestinal mucosa inflammation that could be seen in any part of the gastrointestinal tract from oral to anus. Oral lesions could be the first sign in most patients. The lesions in Crohn’s disease are divided to specific and nonspecific lesions. The specific lesions are less common than nonspecific ones. Tag-like lesions and cobblestones are some of the specific lesions and ulcer is a non-specific lesion. The diagnosis of Crohn’s disease is based on a combination of symptoms, enteroscopy, gastroscopy, capsule endoscopy, histopathology and imaging. Oral involvement of CD is also known as oral Crohn’s disease (OCD). Early diagnosis of OCD may be the most influential factor in controlling it. This case report presents a 47-year-old female patient with gingivitis and gingival erythema and enlargement as her chief complaint which was the first sign of CD. Keywords: Pathology; Oral; Crohn’s disease; Gingival enlargement. https://jcr.tums.ac.ir/index.php/jcr/article/view/492 https://jcr.tums.ac.ir/index.php/jcr/article/download/492/417