Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 12 1 2025 08 25 54 60 Alireza Parhiz Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Morad Karimpour School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran. Farzam Farahmand Faculty of Mechanical Engineering, Sharif University of Technology, Tehran, Iran. Shahrzad Damercheli School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran. Mohammad Hosein Amirzade Iranaq Farinroshaan Medical & Health Co. LTD., Tehran, Iran; Department of Oral and Maxillofacial Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 2025 02 15 2025 07 11 We present a treatment option for extensive mandibular resection using CAD/CAM technology. This option allows for the patient’s immediate and complete rehabilitation and has advantages over autografts. A 73-year-old female patient was diagnosed with Central Giant Cell Granuloma (CGCG). The proposed treatment plan involved an angle-to-angle resection of the mandible along with free flap surgery using an autologous iliac graft; however, the patient declined this option. As a final treatment plan, the possibility of utilizing a customized titanium prosthesis as a patient-specific implant (PSI) was considered. The patient was discharged in good general condition, and remarkably, full function was recovered within 24 hours. Additionally, the patient was able to speak and eat after just 5 hours, a testament to the swift recovery this treatment option offers. The primary benefits of this method are immediate results and swift, accurate surgical procedures, which provide reassurance of its efficiency.  Keywords: Mandibular reconstruction; Patient-specific implant; 3D-printing; Oral surgery; Head and neck cancer. https://jcr.tums.ac.ir/index.php/jcr/article/view/529 https://jcr.tums.ac.ir/index.php/jcr/article/download/529/441