Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 12 1 2025 08 25 65 69 Samira Derakhshan Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran; Cancer Preclinical Imaging Group, Preclinical Core Facility, Tehran University of Medical Sciences, Tehran, Iran. Monir Moradzadeh Khiavi Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Zahra Parnia Baran School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. 2025 03 16 2025 07 19 Ameloblastoma is a benign but locally invasive epithelial odontogenic tumor. Ameloblastoma usually presents in the posterior mandibular ramus region, while it is rare in the anterior mandibular region. It has been divided into three classic types: Unicystic Ameloblastoma (UA), Extraosseous/Peripheral Ameloblastoma, and Conventional Ameloblastoma. The unicystic type accounts for approximately 5-15% of all cases and predominantly occurs in the younger population, typically in the second decade of their life, but is quite rare in older adults. We present a case of mandibular unicystic Ameloblastoma in the anterior area of a 62-year-old Iranian female with intraoral swelling of the gingiva. We reported the clinicoradiographic and histopathological features of the lesion with complete treatment intervention and follow-up.  Keywords: Ameloblastoma; Mural; Odontogenic tumor.  https://jcr.tums.ac.ir/index.php/jcr/article/view/530 https://jcr.tums.ac.ir/index.php/jcr/article/download/530/443