Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 12 2 2025 09 23 70 78 Nima Dehghani Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Mohadeseh Azarsina Private Practice, Tehran, Iran. Xaniar Mahmoudi Department of Oral and Maxillofacial Surgery, Tabriz University of Medical Sciences, Tabriz, Iran. 2025 05 04 2025 07 11 Introduction: This systematic review aims to evaluate the efficacy of antibiotics, particularly those administered preoperatively and postoperatively, in enhancing the success rates of dental implants. Additionally, it seeks to compare current opinions toward antibiotic usage in implant dentistry with documented outcomes of implant success, both with and without antibiotic intervention.  Materials and Methods: We conducted a systematic literature search using the Scopus, PubMed, and Web of Science databases, incorporating studies published between 2010 and January 2023. Search terms included “dental implant,” “antibiotic,” “prophylaxis,” and “survey.” Data analysis and graphical representations were generated using Comprehensive Meta-Analysis (CMA) software.  Results: The findings indicate that 81.1% of surveyed dentists routinely prescribe antibiotic prophylaxis for patients undergoing dental implant procedures, irrespective of health status. An additional 5.8% of practitioners tailored their antibiotic prescriptions based on modifiable factors. The initial database search yielded 220 relevant articles from Scopus, PubMed, and Web of Science, which were screened for alignment with the review objectives. Among antibiotics, penicillin and phenoxymethylpenicillin were identified as the preferred first-line medications.  Conclusion: Cross-sectional surveys across various countries reveal a tendency among dentists to prescribe systemic antibiotic prophylaxis for dental implant surgeries without adhering strictly to evidence-based guidelines, often resulting in overprescription. This highlights a critical need for collaboration among dental educators and practitioners to align clinical practices with scientific evidence regarding antibiotic prophylaxis in implant dentistry.  Keywords: Antibiotics; Dental implant; Systematic review; Meta-analysis. https://jcr.tums.ac.ir/index.php/jcr/article/view/542 https://jcr.tums.ac.ir/index.php/jcr/article/download/542/444