Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 12 3 2025 12 07 214 217 EN Giti Shami School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran. Farnoosh Mohammadi Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. 2025 07 26 2025 09 08 Lipoma is a common tumor of soft tissue with rare occurrence in the oral cavity, accounting for only 1-4% of benign oral tumors. It may be noticed only during routine dental examinations. Most of them rarely cause pain, resulting in a delay in seeking treatment. Lipoma of the oral cavity may occur in any region. The buccal mucosa, tongue, and floor of the mouth are among the common locations. A case of large intraoral lipoma occurring in the sublingual region in a 59-year-old male patient is reported. It was treated surgically under general anesthesia. Keywords: Lipoma; Pathology; Oral; Surgery. https://jcr.tums.ac.ir/index.php/jcr/article/view/552 https://jcr.tums.ac.ir/index.php/jcr/article/download/552/463