Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 12 3 2025 12 07 134 147 Zahra Salmani Department of Periodontics, Faculty of Dentistry, Alborz University of Medical Sciences, Karaj, Iran. Fateme Abedini Department of Periodontology, Faculty of Dentistry, Baqiyatallah University of Medical Sciences, Tehran, Iran. Sahar Chokami Rafiei Research Center for Prevention of Oral and Dental Diseases, School of Dentistry, Baqiyatallah University of Medical Sciences, Tehran, Iran. 2025 08 28 2025 11 14 Introduction: This study aims to determine whether the application of SocketKAPTM (KAP) and SocketKAGETM (KAGE) in tooth extraction sockets can reduce alveolar ridge changes.   Materials and Methods: An electronic search of PubMed, Google Scholar, Scopus and Web of Science databases was conducted up to September 2024. Screening and data extraction were performed independently by two researchers. Three randomized clinical trials (RCTs) were included. This systematic review was done according to the PRISMA 2020 guideline.  Results: All studies showed that KAP alone and KAP+Anorganic bovine bone mineral (ABBM) significantly decreased contour loss in human intact sockets compared with no intervention. KAP+ABBM significantly decreased alveolar bone volume loss in human intact sockets compared with no intervention. KAGE+KAP+ABBM significantly decreased contour loss and alveolar bone volume loss in human sockets with dehiscence compared with no intervention.  Conclusion: The review suggests that KAP and KAGE may be beneficial in reducing alveolar ridge changes, but it is recommended that further studies be conducted to confirm the findings of the review and to determine whether KAP and KAGE are cost-effective interventions for reducing alveolar ridge changes.  Keywords: Alveolar bone grafting; Alveolar process; Bonesubstitute; Tooth extraction; Tooth socket; Wound healing; KAGETM; KAPTM. https://jcr.tums.ac.ir/index.php/jcr/article/view/560 https://jcr.tums.ac.ir/index.php/jcr/article/download/560/454