Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 13 1 2026 05 12 118 122 EN Azin Kheradmand Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Amir Alizadeh Tabrizi Department of Oral and Maxillofacial Surgery, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. Sadra Amir Pour Haradasht Department of Oral and Maxillofacial Surgery, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. Sarina Hassan Pour Dargah Department of Oral and Maxillofacial Surgery, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran. 2025 12 05 2026 04 09 Laryngeal lymphoma is an extremely rare condition. Symptoms are nonspecific and include hoarseness, dysphagia, and respiratory difficulty or airway obstruction. The initial presentation often mimics benign conditions such as inflammation or infection. Early diagnosis is crucial for optimal treatment. A 63-year-old man was admitted with a 1-month history of dysphonia, persistent hoarseness, odynophagia, and mild dyspnea. The patient did not report any fever, weight loss, or night sweats. Complete examination included: general physical examination, comprehensive ENT examination, oral cavity examination, neck examination, stroboscopy, flexible fibrolaryngoscopy, CT scan, MRI, and chest X-ray. Biopsy and IHC confirmed a diagnosis of diffuse large B-cell lymphoma (DLBCL). The patient underwent chemotherapy with the R-CHOP scheme, followed by involved-site radiotherapy (ISRT). After a 2-year follow-up, the patient remained in complete remission. This case emphasizes the importance of considering rare malignancies in patients with nonspecific laryngeal symptoms and the crucial role of a comprehensive diagnostic workup, even when symptoms are more commonly associated with benign conditions such as inflammation, and there is no sign of malignancy. Time is a critical factor for the management of laryngeal lymphoma, as Early diagnosis with appropriate treatment may significantly improve patients’ prognosis.  Keywords: Laryngeal lymphoma; Inflammation; Malignancy. https://jcr.tums.ac.ir/index.php/jcr/article/view/597 https://jcr.tums.ac.ir/index.php/jcr/article/download/597/487