Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 2026 2 2026 08 25 257 266 Yasaman Mirhosseini Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Arghavan Tonkaboni Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Pouyan Aminshakib Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. 2026 05 12 2026 07 24 Lipomas are the most common benign soft tissue tumors, but they occur only rarely in the oral cavity. Fibrolipoma, an uncommon variant, features mature adipose tissue with a prominent fibrous component, presenting as a slow-growing, asymptomatic mass. This article reports a rare case of hard palate fibrolipoma in a 73-year-old male, initially appearing as a small, asymptomatic, sessile nodule clinically suspected to represent a benign palatal lesion, including irritation fibroma, pleomorphic adenoma, mucocele, and lymphoepithelial cyst. Surgical excision was performed, with histopathology confirming fibrolipoma. No recurrence was observed during 20 months of clinical follow-up. Fibrolipoma of the hard palate is exceptionally rare and may present a diagnostic challenge because of its nonspecific clinical appearance. Histopathological examination remains essential for definitive diagnosis, and complete surgical excision is associated with an excellent prognosis and a very low risk of recurrence.  Keywords: Lipoma; Fibrolipoma; Oral mucosa; Hard palate; Oral neoplasm. https://jcr.tums.ac.ir/index.php/jcr/article/view/650 https://jcr.tums.ac.ir/index.php/jcr/article/download/650/506