Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 3 3 2016 09 15 207 210 EN Eshagh Lasemi Department of Oral and Maxillofacial Surgery, Islamic Azad University, Member of cranio-maxillo-facial research center, Islamic Azad University, dental branch, Tehran, Iran. Mehdi Sezavar Department of Oral and Maxillofacial Surgery, Islamic Azad University, Member of cranio-maxillo-facial research center, Islamic Azad University, dental branch, Tehran, Iran. Mohsen ZamaniMiyandashti Cranio-maxillo-facial research center, Islamic Azad University, Dental branch, Tehran, Iran. Seifollah Hemmat Department of Oral and Maxillofacial Surgery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Member of cranio-maxillo-facial research center, Islamic Azad University, dental branch, Tehran, Iran. Elmira ShoarNobari Cranio-maxillo-facial research center, Islamic Azad University, Dental branch, Tehran, Iran. Ali Fateh Cranio-maxillo-facial research center, Islamic Azad University, dental branch, Tehran, Iran. Zeinab Davoudmanesh Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Member of cranio-maxillo-facial research center, Islamic Azad University, dental branch, Tehran, Iran. 2016 09 28 2016 09 28 Introduction: one of the most significant concerns after third molar surgery is the post-surgical dental pain. Regarding the efficacy of the Novafen and Naproxen in pain control treatment, it is important to compare the effect of each of these medications to decide which one should be used. Aim: The aim of this study was to compare the effect of Novafen and Naproxen on pain management in patients after surgical removal of impacted mandibular third molar. Methods and Materials: This study was a clinical trial that was performed as a split mouth and double-blind on 20 patients (12 females and 8 males) with a mean age of (24.2±5.8) which had surgical extraction of impacted mandibular teeth in two different dates. Novafen (Acetaminophen 325mg, Ibuprofen 200mg, and Caffeine 40mg) and Naproxen 500mg were assessed blindly in each date as a pain control treatment. The pain intensity was determined by VAS (Visual Analogue Scale). In this study, data were analyzed based on Mann-whitney U-tests. Results: The mean pain in Novafen group was lower than Naproxen group 4, 8 and 12 hours after surgery (p<0.001). But after 24 hours, pain in both groups were the same and there was no statistically significant difference (p<0.2). Conclusion: The pain in Novafen group was meaningfully lower than Naproxen group hence Novafen can be used as a more effective therapy rather than Naproxen in dental surgeries. Keyword: Naproxen, Novafen, tooth, impacted. https://jcr.tums.ac.ir/index.php/jcr/article/view/89 https://jcr.tums.ac.ir/index.php/jcr/article/download/89/130