Tehran University of Medical Sciences Journal of Craniomaxillofacial Research 2345-5489 3 1 2016 03 15 172 176 EN Fereshteh Baghaii Department of Oral and Maxillofacial Pathology of dentistry school, Tehran University of Medical Science, Tehran, Iran. Mohammad Reza Rokni Private clinician, Tehran, Iran. Sedigheh Rahrotaban Department of Oral and Maxillofacial Pathology of dentistry school, Tehran University of Medical Science, Tehran, Iran. Maryam Jolehar Department of Oral and Maxillofacial Pathology of dentistry school, Tehran University of Medical Science, Tehran, Iran. Azadehzeinab Titidezh Department of Oral and Maxillofacial Pathology of dentistry school, Qazvin University of Medical Science, Qazvin, Iran. Samira Derakhshan Department of Oral and Maxillofacial Pathology of dentistry school, Tehran University of Medical Science, Tehran, Iran. 2016 10 08 2016 10 08 Myofibroma is an uncommon benign mesenchymal neoplasm. Solitary myofibroma is common in soft tissues of head and neck, but rare in the jaw bones. Only a few sporadic cases of solitary myofibroma of mandible have been described. The aim of the present study was to present a clinical case of a patient with a myofibroma in mandible bone and its management. Differentiating this lesion from other benign and malignant neoplasms is crucial in deciding between a radical and a conservative treatment approach. We explained that diagnosis of myofibroma can be reached by a histopathologic and immunohistochemical analysis and surgical excision is the treatment of choice. Key words: Intraosseous, Mandible, Myofibroma. https://jcr.tums.ac.ir/index.php/jcr/article/view/99 https://jcr.tums.ac.ir/index.php/jcr/article/download/99/125