Journal of Craniomaxillofacial Research 2017. 4(2):328-339.

Tooth eruption: a “neuromuscular theory”. part two
LOTO Adolphus Odogun

Abstract


Background/Objective: Tooth eruption is a foundational subject for every dental practitioner as well as dental students; and literature is replete with different mechanisms of migration
of a tooth from its bony crypt into the oral cavity. The purpose of the part two of this study was to evaluate and test the proposed “neuromuscular theory of tooth eruption” using relevant scientific
papers, as supporting bodies of evidence, to unify the currently accepted mechanisms of tooth eruption under single theory.
Materials and Methods: A detailed and systematic analysis, synthesis and integration of the findings from relevant scientific studies (selected according to specific inclusion and exclusion
criteria) on mechanisms of tooth eruption was conducted as it was done with part one of this study.
Results: The propelling force of tooth eruption is attributed to piezoelectricity, mechanosensation, mechanotransduction, mechanical pull on the hydroxyapatite crystals; mechano-hydrodynamic force; and mechanics of the mandible and the orofacial muscles with attendant biochemical, electrical, electrochemical, cellular, molecular and enzymic activities to prepare the jaws and other facial bones for coronal migration of a developing tooth from its bony crypt until it emerges in the oral cavity.
Conclusion: “Neuromuscular theory of tooth eruption” is based on neuromuscular forces, arising from muscular contractions in the orofacial region. Mechanosensation, mechanotransduction
and piezoelectricity are the three principal processes of converting neuromuscular forces into electrical, electrochemical and biochemical energies for initiation and sustenance of cellular, molecular and enzymic activities during the different phases of tooth eruption process. The clinical relevance
of this theory is that it throws more light on the morphological and functional interdependence of the various elements of the maxillo-mandibulo-dental system as well as the need for neuromuscular considerations in the diagnosis, treatment planning, prevention and treatment of pathological
conditions of tooth eruption.
Key words: Mechanosensation, Mechanotransduction, Neuromuscular, Theory, Tooth eruption.

Keywords


Mechanosensation; Mechanotransduction; Neuromuscular; Theory; Tooth eruption

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References


Massler, M., Schour, I. Studies in tooth develop- ment: Theories of eruption. Am J Orthod Oral Surg. 1941; 27:552–576

Marks, S.C., Schroeder, H.E. Tooth eruption: The- ories and Facts. The Anatomical Record. 1996;245:374–393.

Craddock, H.L, Youngson, G.G. Eruptive tooth movement the current state of knowledge. Br Dent J. 2004; 197:385–391.

Ten Cate, A.R., Nanci, A. Physiologic tooth move- ment: Eruption and shedding. in: A. Nanci (Ed.) Oral Histology: Development, Structure and Function. 6. Mosby, Toronto 2003:279–280.[5] Tooth movement. J Dent Res. 2008; 87:414–434.

Sutton, P.R., Graze, H.R. The blood-vessel thrust theory of tooth eruption and migration. Med Hy- potheses. 1985; 18:289–295.

Ash, Major M. and Stanley J. Nelson. Wheeler’s Dental Anatomy, Physiology, and Occlusion. 9th. Edition 2003. P.38- 41.

Ruta Almonaitiene, Irena Balciuniene, Janina Tut- kuviene. Factors influencing permanent teeth eruption. Part one – general factors. Stomatologi- ja, Baltic Dental and Maxillofacial Journal 2010;12: 67-72,

Garn, S.M., Lewis, A.B., Blizzard, R.M. Endocrine factors in dental development. J. Dent. Res. 1965;44:243–258.

Psoter, W., Gebrian, B., Prophete, S., Reid, B., Katz, R. Effect of early childhood malnutrition on tooth eruption in Haitian adolescents. Communi- ty Dent Oral Epidemiol. 2008; 36:179–189.

Adler, P. Studies on the eruption of the permanent teeth. IV. The effects upon the eruption of the per- manent teeth of caries in the deciduous dentition and of urbanization. Acta Genet. 1958; 8:78–91.

Garn, S.M., Lewis, A.B., Kerewsky, R.S. Genetic, nutritional, and maturational correlates of dental development. J Dent Res. 1965; 44:228–242.

Hatton, M.E. Measure of the effects of heredity and environment on eruption of the deciduous teeth. J. Dent. Res. 1955; 34:397–401.

Adler, P. Effect of some environmental factors on sequence of permanent tooth eruption. J. Dent. Res. 1963; 42: 605–616.

Epker BN, Frost HM. Correlation of bone resorp- tion and formation with the physical behavior of loaded bone. Journal of Dental Research 1965; 44:33–44.

Marks, S.C. Jr, Cahill, and D.R. Regional control by the dental follicle of alterations in alveolar bone metabolism during tooth eruption. J Oral Pathol.1987; 16:164–169.

Wise, G.E., Yao, S., Henk, W.G. Bone formation as a potential motive force of tooth eruption in the rat molar. Clin Anat. 2007; 20:632–639.

Wise, G.E., Lin, F., Marks, S.C. Jr et al, The mo- lecular basis of tooth eruption. in: Davidovitch Z. (Ed.) The Biological Mechanisms of Tooth Erup- tion, Resorption and Replacement by Implants. EBSCO Media, Birmingham, AL; 1994:383–390.

Wise, G.E., Frazier-Bowers, S., D’Souza, R.N.Cellular, molecular, and genetic determinants of tooth eruption. Crit Rev Oral Biol Med. 2002;13:323–324.

Sandy C. Marks Jr., Jeffrey P. Gorski and Gary E.Wise. The mechanisms and mediators of tooth eruption – Models for developmental biologists.Int. J. Dev. Biol. 1995; 39:223-230.

Scott, J.M. Development and function of the den- tal follicle. Brit Dent J. 1948; 85:193–195.

Cahill, D.R., Marks, S.M. Jr. Tooth eruption: Ev- idence of the central role of the dental follicle. J Oral Pathol. 1980; 9:189–200.

Wise, G.E., Marks, S.C. Jr, Cahill, D.R. Ultrastruc- tural features of the dental follicle associated with formation of the tooth eruption pathway in the dog. J Oral Pathol. 1985; 14:15–26.

Marks, S.C. Jr, Cahill, D.R., Wise, G.E. The cy- tology of the dental follicle and adjacent alveolar bone during tooth eruption. Am J Anat. 1983;168:277–289.

Gorski, J.P., Marks, S.C. Jr, Cahill, D.R. et al, De- velopmental changes in the extracellular matrix of the dental follicle during tooth eruption. Connec- tive Tissue Research. 1988; 18:175–190.

Gorski, J.P., Marks, S.C., Cahill, D.R. et al, Bio- chemical analysis of the extracellular matrix of the dental follicle at different stages of tooth eruption. in: Davidovitch Z. (Ed.) The Biological Mecha- nisms of Tooth Eruption and Root Resorption. EBSCO Media, Birmingham, AL; 1988:251–260.

Gorski, J.P., Marks, S.C. Current concepts of the biology of tooth eruption. Crit Rev Oral Biol and Med. 1992; 3:185–206.

Wise, G.E., Frazier-Bowers, S., D’Souza, R.N.Cellular, molecular, and genetic determinants of tooth eruption. Crit Rev Oral Biol Med. 2002;13:323–334.

Wise, G.E. Cellular and molecular basis of tooth eruption. Orthod Craniofac Res. 2009; 12:67–73.

Hatakeyama, J., Philp, D., Hatakeyama, Y. et al, Amelogenin-mediated regulation of osteoclasto- genesis, and periodontal cell proliferation and mi- gration. J Dent Res. 2006; 85:144–149.

Shroff, B., Norris, K., Pileggi, R. Protease activity in the mouse dental follicle during tooth eruption. Arch Oral Biol. 1995; 40:331–335.

Cielinski, M.J., Jolie, M., Wise, G.E. et al, Colo- ny-stimulating factor (CNS-1) is a potent stimula- tor of tooth eruption in the rat. in: Davidovitch Z. (Ed.) Biological Mechanisms of Tooth Eruption, Resorption and Replacement by Implants. EBSCO Media, Birmingham, AL; 1994:429–436.

Wise, G.E., Lin, F. Regulations and localization of colony stimulating factor-1 mRNA in cultured dental follicle cells. Arch Oral Biol. 1994; 39:621–627.

Wise, G.E., Lin, F., Zhao, L. Transcription and translation of CSF-1 in the dental follicle. J Dent Res. 1995; 74:1551–1557.

Shroff, B., Rothman, J.R., Norris, K. et al, Follic- ular apoptosis during tooth eruption. in: Davi- dovitch A., Mah J. (Eds.) Biological Mechanisms of Tooth Eruption, Resorption and Replacement by Implants. EBSCO Media, Birmingham, AL; 1998:71–77.

Logan, W., Kronfeld, R. Development of the hu- man jaws and surrounding structures from birth to the age of fifteen years. J. Am. Dent. Assoc.1933; 20:379–427.

Cruz DZ, Rodrigues L, Luz JGC. Effects of detach- ment and repositioning of the medial pterygoid muscle on the growth of the maxilla and mandi- ble of young rats. Acta Cir Bras. 2009 Mar-Apr;24(2):93-7.

Rodrigues L, Traina AA, Nakamai LF, Luz JGC.Effects of the unilateral removal and dissection of the masseter muscle on the facial growth of youngrats. Braz Oral Res. 2009 Jan-Mar; 23 (1):89-95.

Kiliaridis S. Masticatory muscle influence on craniofacial growth. Acta Odontol Scand. 1995 Jun;53(3):196-202.

Sarnat BG, Robinson IB. Experimental changes of the mandible. A serial roentgenographic study. J Craniofac Surg. 2007Jul; 18(4):917-25.

Whetten LL, Johnston LE Jr. The control of con- dylar growth: An experimental evaluation of the role of the lateral pterygoid muscle. Am J Orthod. 1985 Sep;88(3):181-9

Fernanda Engelberg Fernandes Gomes, Rogério Bonfante Moraes, João Gualberto C Luz. Effects of temporal muscle detachment and coronoidoto- my on facial growth in young rats. Brazilian oral research August 2012; 26(4):348-54 ·

Miller, AJ, Chierici, G. The bilateral response of the temporal muscle in the rhesus monkey (Ma- cacca mulatta) to detachment of the muscle and increased loading of the mandible. J Dent Res.1977;56:1620.

Kiliaridis S, Mejersjo C, Thilander B. Muscle func- tion and craniofacial morphology: a clinical study in patients with myotonic dystrophy. Eur J Orthod 1989; 11:131-138.

Kiliaridis S. Masticatory muscle function and cra- niofacial morphology. Swedish Dental Journal Suppl. 36, 1986.

Kiliaridis S. The importance of masticatory mus- cle function in dentofacial growth. Seminars in orthodontics 2006; 12(2):110-119.

Bsset, CAL Electrical effects in bone. Scientific American 1965, 213(4): 18–25.

Basset, C.A.L. Biological significance of Piezo electricity. Calcified Tissue Research 1964, 1: 252-272.

Basset, C.A.L. and R.O. Beker .Generation of elec- trical potential by bone in response to mechanical stress. Science 137: 1063 – 1064.

Basset, C.A.L, Robert J. Pawluk, and Robert O.Beker. Effect of electrical currents on bone in vivo.Nature 204: 652-654.

Athenstaedt H. Pyroelectric and piezoelectric be- havior of human dental hard tissues. Arch Oral Biol 1971; 16: 495-501. [52] Kung, C., A possible unifying principle for mechanosensation. Nature,2005. 436(7051): 647-54.

Vogel, V. and M. Sheetz, Local force and geometry. sensing regulate cell functions. Nat Rev Mol Cell Biol, 2006. 7(4):265-75.

Vogel, V., Mechanotransduction involving multi- modular proteins: converting force into biochem- ical signals. Annu Rev Biophys Biomol Struct,2006. 35: p. 459-88.

Discher, D.E., P. Janmey, and Y.L. Wang, Tissue cellsfeel and respond to the stiffness of their sub- strate. Science, 2005. 310(5751): p. 1139-43.

Li, C. and Q. Xu, Mechanical stress-initiated sig- nal transductions in vascular smooth muscle cells. Cell Signal, 2000; 12(7):435-45.

Akitake, B., Anishkin, A., Liu, N., and Sukharev, S.Straightening and sequential buckling of the pore-lining helices define the gating cycle of Msc S. Nat.Struct. Mol. Biol. 2007; 14:1141–1149.

Coste, B., Mathur, J., Schmidt, M., Earley, T. J., Ranade, S., Petrus, M. J., et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 2010; 330:55-60

Coste, B., Xiao, B., Santos, J. S., Syeda, R., Grandl, J., Spencer, K. S.,et al. Piezo proteins are pore-form- ing subunits of mechanically activated channels. Nature 2012; 483:176–181.

Hamill, O. P., and Martinac, B. Molecular basis of mechanotransduction in living cells. Physiol. Rev.2001; 81:685–740.

Hayakawa, K., Tatsumi, H., and Sokabe, M. Mech- ano-sensing by actin filaments and focal adhesion proteins. Commun. Integrin. Biol. 2012; 5:572–577.

Sackin, H. “Mechanosensitive channels”. Annu.Rev. Physiol.1995; 57: 333–53.

Ernstrom GG, Chalfie M. “Genetics of sensory mechanotransduction”. Annu. Rev. Genet. 2002;36: 411– 53.

Sachs F. “Stretch-activated ion channels: what are they?” Physiology (Bethesda) 2010; 25 (1): 50–6.

Gillespie, Peter G.; Walker, Richard G. (2001). “Molecular basis of mechanosensory transduc- tion”. Nature. 413 (6852):194–202.

Grigg, P. “Biophysical studies of mechanorecep- tors”. Journal of applied physiology 1986; 60 (4):1107–15.

Burkholder, TJ. “Mechanotransduction in skeletal muscle.” Frontiers in Bioscience 2007; 12: 174–91.

Tidball JG. Mechanical signal transduction in skeletal muscle growth and adaptation. Journal of Applied Physiology 2005; 98:1900–8.

Ingber DE. Tensegrity: the architectural basis of cellular mechanotransduction. Annual Review of Physiology 1997; 59:575–99.

Ingber DE. Opposing views on tensegrity as a structural framework for understanding cell me- chanics. Journal of Applied Physiology 2000; 89:1663–70.

Kumar A, Chaudhry I, Reid MB, Boriek AM. Dis- tinct signaling pathways are activated in response to mechanical stress applied axially and trans- versely to skeletal muscle fibers. Journal of Biolog- ical Chemistry 2002; 277(46):493–503.

Iqbal J, Zaidi M. Molecular regulation of mech anotransduction. Biochemical & Biophysical Re- search Communications 2005; 328:751–5.

Martineau LC, Gardiner PF. Insight into skeletal muscle mechanotransduction: MAPK activation is quantitatively related to tension. Journal of Ap- plied Physiology 2001; 91:693–702.

Vandenburgh HH, Hatfaludy S, Sohar I, Shan- sky J. Stretch-induced prostaglandins and protein turnover in cultured skeletal muscle. American Journal of Physiology 1990; 259:C232–40.

Vandenburgh HH, Shansky J, Solerssi R, Chro- miak J. Mechanical stimulation of skeletal muscle increases prostaglandin F2 alpha production, cy- clooxygenase activity, and cell growth by a pertus- sis toxin sensitive mechanism. Journal of Cellular Physiology. 1995;163:285–94.

Katsumi A, Orr AW, Tzima E, Schwartz MA (2004) Integrins in mechanotransduction J Biol Chem, 279 (13):12001–4.

Bonewald LF (2006) Mechanosensation and trans- duction in osteocytes. Bone key Osteovision 3:7-15.

Bonewald LF (2011) The amazing osteocyte. J Bone Miner Res 26: 229-238.

Kulkarni RN, Bakker AD, Gruber EV, Chae TD, Veldkamp JBB, Klein-Nulend J, Everts V MT1- MMP modulates the mechanosensitivity of osteo- cytes. Biochem Biophys Res Commun 2012; 417:824-829.

Lanyon LE, Rubin CT. Static vs. dynamic loads as an influence on bone remodelling. J Biomech.1984; 17:897- 905.

Malone AM, Anderson CT, Tummala P, Kwon RY, Johnston TR, Stearns T, Jacobs CR. Primary cilia mediate mechanosensing in bone cells by a calci- um-independent mechanism. Prox Natl Acad Sci USA 2007a; 104: 13325-13330.

Robling AG, Bellido T, Turner CH. Mechanical stimulation in vivo reduces osteocyte expression of sclerostin. J Musculoskelet Neuronal Interact 2006; 6: 354.

Rubin CT, Lanyon LE . Kappa Delta Award pa- per. Osteoregulatory nature of mechanical stimuli: function as a determinant for adaptive remodeling in bone. J Orthop Res 1987; 5: 300-310.

Trepat X, Deng L, An SS, Navajas D et al. Univer- sal physical responses to stretch in the living cell. Nature 2007; 447: 592-595.

Patel TJ, Lieber RL. Force transmission in skeletal muscle: from actomyosin to external tendons. Ex- ercise & Sport Sciences Reviews. 1997; 25:321–63.

Janmey PA. The cytoskeleton and cell signaling: component localization and mechanical coupling. Physiol Rev 1998; 78: 763-781.

You L, Temiyasathit S, Lee P. et al. Osteocytes as mechanosensors in the inhibition of bone resorp- tion due to mechanical loading. Bone 2008; 24:172-179.

Burra S, Nicolella DP, Francis WL. et al. Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels. Proc Natl Acad Sci USA 2010; 107: 13648-13653.

Fritton SP, Weinbaum S. Fluid and solute trans- port in bone: flow-induced mechanotransduction. Annu Rev Fluid Mech 2009; 41: 347-374.

J. Klein-Nulend, R.G. Bacabac and A.D. Bakker.Mechanical loading and how it affect bone cells:the role of the osteocyte cytoskeleton in main-taining our skeleton. European Cells and Materils2012; 24:278-291.

Zhang Y, Paul EM, Sathyendra V. Enhanced osteo- clastic resorption and responsiveness to mechani- cal load in gap junction deficient bone. PLoS One2011; 6: e23516.

Elson EL. Cellular mechanics as an indicator of cytoskeletal structure and function. Annu Rev Biophys Biophys Chem 1988; 17:397–430.

Evans E, Hochmuth RM. Mechanical properties of membranes. in Topics in Membrane and Trans- port, eds Kleinzeller A, Bronner F (Academic, New York), 1978; 10:1–64

Owen P. Hamill, Boris Martinac. Molecular Basis of Mechanotransduction in Living Cell Physiolog- ical Reviews Published 1 April 2001 Vol. 81 no. 2,685-740.

Moxham BJ, Grant DA. Development of the peri- odontal ligament. In: Berkovitz BKB, Moxham BJ, Newman HN, editors. The periodontal ligament in health and disease. London: Mosby-Wolfe;1995. pp. 161–181.

Berkovitz BKB, Moxham BJ.The development of the periodontal ligament with special reference to collagen fibre ontogeny. J Biol Buccale. 1990;18:227–236.

Moxham BJ, Berkovitz BKB. The periodontal lig- ament and physiological tooth Movements.In: Berkovitz BKB, Moxham BJ, Newman HN, edi- tors. The periodontal ligament in health and dis- ease. Oxford: Pergamon Press; 1982. pp. 215–247.

Mc Culloch CAG, Lekic P, McKee MD. Role of physical forces in regulating the form and func- tion of the periodontal ligament. Periodontol 2000. 2000; 24:56–72.

Chiquet M, Gelman L, Lutz R, Maier S. From mechanotransduction to extracellular matrix gene expression in fibroblasts. Biochim Biophys Acta.2009; 1793:911–920.

Kook S-H, Hwang J-M, Park J-S, et al. Mechan- ical force induces type I collagen expression in human periodontal ligament fibroblasts through activation ofERK/JNK and AP-1. J Cell Biochem.

; 106:1060–1067.

Walter Lewin. Newton’s First, Second, and Third Laws. MIT Course 8.01: Classical Mechanics, Lecture 6. (20 September 1999). Cambridge, MA USA: MIT OCW. Event occurs at 0:00–6:53. Re- trieved 23, December 2010.

C. T. O. Sullivan. Newton’s laws of motion: some interpretations of the formalism, Amer. J. Phys.1980; 48 (2) 131-133.

H. Erlichson. Motive force and centripetal force in Newton’s mechanics. Amer. J. Phys. 1991; 59 (9)842-849.

Suri, L., Gagari, E., Vastardis, H. Delayed tooth eruption: Pathogenesis, diagnosis, and treatment (A literature review). Am J Orthod Dentofac Or- thop. 2004; 126:432–445.

Sauk, J.J. Genetic disorders involving tooth erup- tion anomalies. The biological mechanisms of tooth eruption and root resorption. in: Davido- vitch Z. (Ed.) EBSCO Media, Birmingham, AL;1988:171–179.

Johnsen, D. Prevalence of delayed emergence of permanent teeth as a result of local factors. J Am Dent Assoc. 1977; 94:100–106.

Brin, I., Solomon, Y., Zilberman, Y. Trauma as a possible etiologic factor in maxillary canine im- paction. Am J Orthod. 1993; 104:132–137.

Andersson, l., Blomlof, L., Lindskog, S. et al.Tooth ankylosis: Clinical, radiographic and histo-logical ssessments. Int J Oral Surg. 1984; 13:423–431.

Raghoebar, G.M., Boering, G., Vissink, A. Clin- ical, radiographic and histological characteristics of secondary retention of permanent molars. J Dent. 1991; 19:164–170.

Bondemark, L., Tsiopa, J. Prevalence of ectopic eruption, impaction, retention and agenesis of the permanent second molar. Angle Orthod. 2007;77:773–778.

Biederman, W. Etiology and treatment of tooth ankylosis. Am J Orthod. 1962; 48:670–684.

Frazier-Bowers, S.A., Koehler, K.E., Ackerman, J.L. et al, Primary failure of eruption: Further characterization of a rare eruption disorder. Am J Orthod Dentofac Orthop. 2007; 131:e1–e11.

Frazier-Bowers, S.A., Simmons, D., Koehler, K. et al. Genetic analysis of familial non-syndromic pri- mary failure of eruption. Orthod Craniofac Res.2009; 12:74–81.

Ertürk N. Doğan The effect of neuromuscular diseases on the development of dental and occlu- sal characteristics. Quintessence Int. 1991 Apr;22(4):317-21.

Alder AB, Crawford GN, Edwards RgG. The ef- fect of denervation on the longitudinal growth of a voluntary muscle. Proc R Soc Lond B Biol Sci.1960 Mar 1; 151:551–562.

Engel WK, Karpati G. Impaired skeletal muscle maturation following neonatal neurectomy. Dev Biol. 1968 Jun;17 (6):713–723.

Hylander, W. L. The human mandible: lever or link? Am. J. Phys. Anthrop. 1975; 43: 227-242.


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