Periodontal condition and total antioxidant status in serum among patients with polycystic ovarian syndrome

  • Shamsoulmolouk Najafi Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
  • Amir Abbas Zahedi Dentistry
  • Arghavan Tonkaboni Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Mojgan Feli International campus of Tehran university of medical science/ faculty of dentistry, Tehran, Iran.
  • Sima Amini International campus of Tehran university of medical science/ faculty of dentistry, Tehran, Iran.
  • Atossa Mahdavi MPH.MD, Assistant Professor, School of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: Polycystic Ovarian Syndrome, Total Antioxidant Status, Periodontal Status, Community Periodontal Index, Periodontal disease Index.

Abstract

Background and Aims: The most prevalent endocrine disease with unknown etiology among women in their fertility period is Polycystic Ovarian Syndrome (PCOS). The disease causes some changes in oxidative stress system, which in turn, is associated with such diseases as metabolicsyndrome, diabetes, cardiovascular diseases, and periodontitis. The present study investigated periodontal status and total antioxidant status in serum of women with PCOS.Materials and Methods: In this cross-sectional, analytic study eighty women, 40 with PCOS as cases and 40 infertile women without PCOS participated. Interview, oral examination and radiographs, and laboratory tests served as data collection tools. Body Mass Index (BMI), CommunityPeriodontal Index (CPI), Periodontal Disease Index (PDI), bone loss, and total anti-oxidant status (TAS) in serum of the participants were measured. Chi-squre test, Mann-Whithney test, and linear regression served for statistical analysis.Results: While in case group 21 patients had bone loss, in control group bone loss was found in 11 pateints (P=0.022). The distribution of maximum CPI score among cases was significantlydifferent from that among controls in that more frequent higher scores existed among cases (P=0.016). The mean PDI in case and control group was 6.23±3.3 and 4.48±2.6, respectively (P=0.015). In general linear model the level of serum TAS was significantly associated with CPI (P=0.039) and BMI (P=0.019).Conclusion: Women with PCOS seem to be more susceptible to periodontal disease compared to other women. This calls for comprehensive periodontal care and regular dental visits for patientwith PCOS.Keywords: Polycystic Ovarian Syndrome, Total Antioxidant Status, Periodontal Status, Community Periodontal Index, Periodontal disease Index.

References

Eman M. Sayed Ahmed, Mohamed E. Salem, Mohamed Samir Eid Sweed. Effect of Lifestyle Modifications on Polycystic Ovarian Syndrome Symptoms.Journal of American Science 2012; 8(8).

Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, etal.onsensus on womans health aspects of polycysticovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS consensus workshopgroup. Fertil Steril. 2012 jan; 97 (1): 28-38.

Sam S, Dunaif A. Polycystic ovary syndrome:Syndromexx? Trends Endocrinol Metab. 2003 Oct;14(8):365-70.

Borges I Jr, Moreira EA, Filho DW, de Oliveira TB,da Silva MB, Fröde TS. Proinflammatory and oxidativestress markers in patients with periodontaldisease. Mediators Inflamm. 2007; 2007:45794.

Van der Velden U, Kuzmanova D, Chapple IL. Micronutritionalapproaches to periodontal therapyJ Clin Periodontol. 2011; 38(Suppl 11):142–58.

Halliwell B, Gutteridge JM. The antioxidants of humanextracellular fluids. Arch Biochem Biophys.1990 Jul; 280(1):1-8.

Murray RK, Granner DK, Mayes PA, Rodweii VW.Harper,s biochemistry. 23 ed.USA: Appleton &Lange;1993.

D’Aiuto F, Sabbah W, Netuveli G, Donos N, HingoraniAD, Deanfield J, et al. Assosiation of themetabolic syndrome with severe periodontitis in alarge U.S. population-based survey. J Clin EndocrinolMetab. 2008; 93:3989-94.

Kinane D, Bouchard P; Group E of European Workshopon Periodontology. Periodontal diseases andhealth: Consensus Report of the Sixth EuropeanWorkshop on Periodontology. J Clin Periodontol.2008 Sep; 35 (8Suppl):333-7.

Bullon P1, Morillo JM, Ramirez-Tortosa MC,Quiles JL, Newman HN, Battino M. Metabolicsyndrome and periodontitis: is oxidative stress acommon link? J Dent Res. 2009 Jun; 88(6):503-18.

Wolf HF, Hassell TM. Color Atlas of Dental HygienePeriodontology. New York: Thieme; 2006.

Dursun E1, Akalın FA, Güncü GN, Çınar N, AksoyDY, Tözüm TF, Kılınc K, Yıldız BO. Periodontaldisease in polycystic ovary syndrome. FertilSteril. 2011 Jan; 95(1):320-3.

Takane M, Sugano N, Ezawa T, Uchiyama T, Ito K.A marker of oxidative stress in saliva: associationwith periodontally-involved teeth of a hopelessprognosis. J Oral Sci. 2005 Mar; 47(1):53-7.

Newman MG, Takei HH, Carranza FA. Carenza’sClinical Periodontatology. 11th ed. Philadelphia:WB Saunders Co; 2011.104-6, 506-511.

Ozçaka O, Oztürk Ceyhan B, Akcali A, BiçakciN, Lappin DF, Budunelı N. Is there an InteractionBetween Polycystic Ovary Syndrome and GingivalInflammation? J Periodontol 2012 Apr 17.

González F1, Rote NS, Minium J, Kirwan JP. Increasedactivation of nuclear factor kappaB triggersinflammation and insulin resistance in polycysticovary syndrome. J Clin Endocrinol Metab.2006 Apr; 91(4):1508-12. Epub 2006 Feb 7.

Cerielo A1, Motz E, Cavarape A, Lizzio S, RussoA, Quatraro A, Giugliano D. Hyperglycemiacounterbalances the antihypertensive effect ofglutathione in diabetic patients: evidence linkinghypertension and glycemia through the oxidativestress in diabetes mellitus. J Diabetes Complications.1997 Jul-Aug; 11(4):250-5.

Kaneto H1, Katakami N, Kawamori D, MiyatsukaT, Sakamoto K, Matsuoka TA, Matsuhisa M, YamasakiY. Involvement of oxidative stress in thepathogenesis of diabetes. Antioxid Redox Signal.2007 Mar; 9 (3):355-66.

Liu J, Zhang D. The role of oxidative stress in thepathogenesis of polycystic ovary syndrome. SichuanDa Xue Xue Bao Yi Xue Ban. 2012 Mar;43(2):187-90.

Yildiz BO, Knochenhauer ES, Azziz R. Impact of obesity on the risk for polycystic ovary syndrome.J Clin Endocrinol Metab. 2008 Jan;93(1):162-8.

Akalin FA, Baltacioğlu E, Alver A, Karabulut E.Lipid peroxidation levels and total oxidant statusin serum, saliva and gingival crevicular fluid inpatients with chronic periodontitis. J Clin Periodontol.2007 Jul; 34(7):558-65.

Signorini AM, Fondelli C, Renzoni E, PuccettiC, Gragnoli G, Giorgi G. Antioxidant effect ofgliclazide,glibenclamide and metformin in patientswithtype 2 diabetes mellitus, Current TherapeuticResearch. 2002; 63:411–420.

Published
2017-12-10
How to Cite
1.
Najafi S, Zahedi AA, Tonkaboni A, Feli M, Amini S, Mahdavi A. Periodontal condition and total antioxidant status in serum among patients with polycystic ovarian syndrome. jcr. 4(4):421-6.
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Original Article(s)