Radio frequency effects on patients with trigeminal neuralgia

  • Shamsolmolouk Najafi Department of Community Oral Health, School of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
  • Arman Taheri Associated Professor of Anesthesiology, Tehran University of Medical Sciences, Tehran, Iran.
  • Mohammad Javad Kharrazi Fard Research Advisor, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Ali Farahini Graduate Student of School of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: Trigeminal neuralgia, Facial pain, Radiofrequency, Interventional approach.


Background: Trigeminal neuralgia is one of the most painful conditions in the head and face. This study was carried out to evaluate the effects and results of RF therapy on patients with trigeminal neuralgia who referred  to Amir-alam Hospital.  Materials and Methods: In this descriptive study, 84 patients with trigeminal neuralgia pain were studied. Patients were diagnosed based on their medical histories, physical examination, and paraclinical tests. Patients are admitted according to internationally accepted criteria such as the International Headache Society (IHS). The patients responded to the questions in the questionnaire before and after the surgery. In this questionnaire, the pain level of patients is assessed by the Visual Analogue Pain Scale (VAS). Results: The mean pain score before treatment was 7.87, which decreased to 4.83 after the treatment. According to the results obtained in this study, 18 patients (21.4%) felt 4 levels of decrease in pain, as the predominant level of relief. Also, 15 patients (17.9%) did not feel any subtraction of pain after the treatment. Of  the 84 patients, only 1 patient experienced the reduction of pain as 9 levels of VAS, after the treatment. There was a significant relationship (P=0.000) between the pain severity and the reduction in the amount of pain after the RF in respect to the amount before the treatment. Also, in the regression equation obtained from the study  of the effects and role of patients’ age, gender, as well as the history of pain in patients before the RF treatment, only the gender of the patients had a significant relationship with the amount of pain reduction and comparison of its pre and post treatment. (P=0.054) and (B= -0.886) and (β= -0.216). Also, there was no significant relationship between pain intensity (P=0.761), age of patients (P=0.829), or history of pain (P=0.139) with pain reduction and comparison of pain intensity before and after RF treatment. During the  treatment of RF, very few side effects was reported. Conclusion: According to the results, RF treatment is an effective method for reducing pain in both short-term and long-term pain, in patients with trigeminal neuralgia. It is suggested that in patients suffering from the pain resulting caused by trigeminal neuralgia, due to drug resistance or who are intolerance to possible adverse effects, or in patients with lack of response from drug therapy, the therapeutic approach of RF is a  valuable way for pain relief.


Buurchiel K.J. Trigeminal neuropathic pain. Acta neurochir supplement.1993;58;148-9.

Jannetta PJ. Arterial compression of trigeminal nerve at the pons in patients with trigeminal neuralgia. J. Neurosurgery 1967;26;159-62.

Subashree.R. medical management of trigeminal neuralgia. IOSR journal of dental and medical sciences (IOSR-JDMS) Nov.-Dec. 2013; 12(2).

Benoliel R, Sharav Y. Chronic orofacial pain. Curr Pain Headache Rep.2001;14(1):33-40.

Jens c.Torp, Dr. Med Dent and John P.Gobbetlin, school of dentistry Michigan Trigeminal neuralgia versus atypical facial pain, a review of literature and case report. Oral surgery and med pathol aradio endod 1996;81;424-32.

Bennetto L, Patel NK, Fuller G. Trigeminal neuralgia and its management. BMJ 2007; 334: 201.

El Otmani H, Moutaouakil F, Fadel H, Slassi I. [Familial trigeminal neuralgia]. Rev Neurol (Paris) 2008; 164: 384-387.

Siqueira SR, Alves B, Malpartida HM et al. Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia. Neuroscience 2009; 164:573-577.

El-tallawy HN, farghalya WM, rageha TA,Shaehatta GA, Hakkem NA, Badry R et al. prevelance of trigeminal neuralgia in Al-Quseir city(red sea Governorate), Egypt. Clin neuroland neurosurg. 2013;1-3.

Liu J, Dai J, Lingling E,Wang D, Liu H. trigeminal neuralgia may be cuased by abnormality of the trigger zone. Med hypotheses. 2010;74(2010):818-9.

Peschillo S, Delfini R. Trigeminal neuralgia: a new neuroimaging perspective.World neursurg. 2010;1-3.

Fromm GO. Sessile BJ summary and conclusion. In fromm GH, sessile Trigeminal neuralgia concepts regarding pathogenesis and treatment. Boston butterworth Heinemann 1991: 205-19.

Sprotte G.Gesischtsschme in zenzM, Jurna L eds, lehrbuch der schmerztherapie. Stuttgart. Weissenchafliche, verlagsgesellshaft 1993; 405-16.

Loser JD Tic-douloureux and atypical facial pain. Wall PD melzack, eds, textbook of pain 3rd ed, Edinburgh chruchill Livingston. 1994;699-710.

Headache classification subcommittee of the international headache society. The international classification of headache disorders: 2nd edition. Cephalalgia 2004; 24: 9-160.

Han JH1, Kim DG, Chung HT, Paek SH, Kim YH, Kim CY, Kim JW, Kim YH, Jeong SS. Long-term outcome of gamma knife radiosurgery for treatment of typical trigeminal neuralgia. 2009 Nov; 1;75(3):822-7.

Kleef MV, Genderen WEV, Narouze S,Nurmikko TJ, Zundert JV, Geurts JW et al.Trigeminal neuralgia. World Institute of Pain. Pain Pract. 2009;9(4):252-9.

Merritt HH. Merritt's neurology: Lippincott Williams & Wilkins; 2010.

Aria yp, hatakeyama n, nishihara m, ikeuchi m, kurisuno m, ikemoto t. intravenous lidocaine and magnesium for management of intractable trigeminal neuralgia: a case series of nine patients. J Anesth. 2013;27(6):960-2.

Obermann M. Treatment options in trigeminal neuralgia. Ther adv Neurol Disord 2010;3 107-115.

Beydoun A. Safety and efficacy of oxcarbazepine: results of randomized, double-blind trials. Pharmacotherapy 2000; 20:152-158.

Latchaw JP, Hardy RW, Forsuthe SB, et al. Trigeminal neuralgia treated by radoifrequency coagulation. J Neurosurg ganglion. Neurosurg 1983;59:479-84.

Nugent GR, Berry B. Trigeminal neuralgia treated bu diffential percutaneous radiofrequency coagulatoin of the Gasserian ganglion. Neurosurg 1974;40:517-23.

Lopez BC, Hamlyn PJ, Zakrzewska JM. Systematic review of ablative neurosurgical techniques for the treatment of trigeminal neuralgia. Neurosurgery 2004 Apr;54:973-983.

Motamedi MH, Rahmat H, Bahrami E, Sadidi A, Navi F, Asadollahi M, Eshkevari PS. Trigeminal neuralgia and radiofrequency. J Calif Dent Assoc. 2009;37:109-14.

Dessey R Emril, Kok-Yuen Ho. Treatment of trigeminal neuralgia: role of radiofrequency ablation.Journal of pain research 10 December 2010.

Dessy R Emril, Kok-Yuen Ho. Treatment of trigeminal neuralgia: role of radiofrequency ablation. Journal of Pain. 12 December 2010; 3: 249–254.

D.Haemmerich, D.M.Mahvi, F.T.Lee Jr, J.G. Webster. RF ablation at audio arequencies preferentially targets tumor, A finite element study. Proceedings of the second joint EMBS/BMES conference Houston, TX, USA October 23-26, 2002.

Beydoun A. Safety and efficacy of oxcarbazepine: results of randomized, double-blind trials. Pharmacotherapy 2000; 20:152-158.

Zakrzewska JM, Patsalos PN. Long-term cohort study comparing medical (oxcarbazepine) and surgical management of intractable trigeminal neuralgia. Pain 2002; 95:259-266.

Moraci A, Buonaiuto C, Punzo A, et al. Tigeminal neuralgia treated by percutaneous thermocoagulation. Comparative analysis of percutaneous thermocoagulation and orhter procedures. Neurochirurgia 1992:35:48-35.

Kampolat Y, Savas A, Bekar A, Berk C (2001) Percutaneous controlled radiofrequency trigeminal rhizotomy for the treatment of idiopathic trigeminal neuralgia: 25-year experience with 1600 patients. Neurosurgery 48: 524–532.

Wael Fouad. Management of trigeminal neuralgia by radiofrequency thermocoagulation. Alexandria Journal of Medicine March 2011; 47(1): 79-86.

How to Cite
Najafi S, Taheri A, Kharrazi Fard MJ, Farahini A. Radio frequency effects on patients with trigeminal neuralgia. J Craniomaxillofac Res. 5(2):72-8.
Original Article(s)