Immunohistochemical expression of SOX2 in oral normal epithelial, dysplasia and squamous cell carcinoma

  • Pouria Motahhary Oral and Maxillofacial Pathologist, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Mahnaz Sahebjamee Oral Medicine Department, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Maryam Nasimi Dermatology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Zohreh Khodashenas Student of Dermatology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Fatemeh Hajian Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Kambiz Kamyab Dermatopathology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: Oral squamous cell carcinoma; Oral epithelial dysplasia; SOX2.

Abstract

Objective: Oral squamous cell carcinoma (SCC) is an aggressive neoplasm with serious morbidityand mortality, which typically spreads through local invasive growth. A key approach to this tumor would be to detect potentially malignant lesions at their early stages. The transcription factor, Sex determining region Y-box 2 (SOX2) is an essential regulator of pluripotent stem cells and promotes developmentand maintenance of squamous epithelia.Materials and Methods: We retrospectively reviewed the charts of 24 samples of SCC, oral epithelial dysplasia and control group, then immunohistochemical staining was performed to detect SOX2 expression.Results: Comparisons between SCC and oral epithelial dysplasia group did not reveal any significantdifference (p=0.496); also values of control and oral epithelial dysplasia group were statically different (p<0.001). Similarly, a significant difference was observed between the values of SCC and controls’ (p<0.001).Conclusion: In conclusion, SOX2 overexpression is seen in oral dysplasia and SCC and their detection in early stages could be crucial for early tumor identification.Keywords: Oral squamous cell carcinoma,oral epithelial dysplasia, SOX2.

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Published
2018-09-23
How to Cite
1.
Motahhary P, Sahebjamee M, Nasimi M, Khodashenas Z, Hajian F, Kamyab K. Immunohistochemical expression of SOX2 in oral normal epithelial, dysplasia and squamous cell carcinoma. jcr. 5(2):74-9.
Section
Original Article(s)