Immunohistochemical expression of SOX2 in oral normal epithelial, dysplasia and squamous cell carcinoma

  • Pouria Motahhary Oral and Maxillofacial Pathologist, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Mahnaz Sahebjamee Oral Medicine Department, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Maryam Nasimi Dermatology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Zohreh Khodashenas Student of Dermatology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Fatemeh Hajian Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Kambiz Kamyab Dermatopathology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: Oral squamous cell carcinoma; Oral epithelial dysplasia; SOX2.


Objective: Oral squamous cell carcinoma (SCC) is an aggressive neoplasm with serious morbidityand mortality, which typically spreads through local invasive growth. A key approach to this tumor would be to detect potentially malignant lesions at their early stages. The transcription factor, Sex determining region Y-box 2 (SOX2) is an essential regulator of pluripotent stem cells and promotes developmentand maintenance of squamous epithelia.Materials and Methods: We retrospectively reviewed the charts of 24 samples of SCC, oral epithelial dysplasia and control group, then immunohistochemical staining was performed to detect SOX2 expression.Results: Comparisons between SCC and oral epithelial dysplasia group did not reveal any significantdifference (p=0.496); also values of control and oral epithelial dysplasia group were statically different (p<0.001). Similarly, a significant difference was observed between the values of SCC and controls’ (p<0.001).Conclusion: In conclusion, SOX2 overexpression is seen in oral dysplasia and SCC and their detection in early stages could be crucial for early tumor identification.Keywords: Oral squamous cell carcinoma,oral epithelial dysplasia, SOX2.



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How to Cite
Motahhary P, Sahebjamee M, Nasimi M, Khodashenas Z, Hajian F, Kamyab K. Immunohistochemical expression of SOX2 in oral normal epithelial, dysplasia and squamous cell carcinoma. jcr. 5(2):74-9.
Original Article(s)