Human dental pulp stem cells differentiation: A review

  • Elham Mohammadi Golrang School of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
  • Fatemeh Dibaji Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
  • Naghmeh Bahrami Craniomaxillofacial Research Center, Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Atena Mohammadi Golrang Department of Kinesiology and Physical Education, Mc Gill University, Montreal, Quebec, Canada.
Keywords: Human dental pulp stem cells (HDPSCs), Differentiation, Bioactive factors, Inductive factors.

Abstract

The advent of regenerative medicine has brought us the opportunity to regenerate, modify and restore human organs function. Stem cells, a key resource in regenerative medicine, are defined as clonogenic, self-renewing, progenitor cells that can generate into one or more specialized cell types. Human dental pulp stem cells (HDPSCs) are ectodermal-derived stem cells, originating from migrating neural crest cells and are capable of providing enough cells for potential cell-basedtherapies. During last decade, HDPSCs have received extensive attention in the field of tissue engineering and regenerative medicine due to their accessibility and ability to differentiate in severalcell phenotypes. In this review, we have described the potential of HDPSCs to differentiate into odontoblasts, osteoblasts, hepatocytes, neuroblasts and angioblasts in response to different bioactive factors. Therefore, the culture and selective differentiation of HDPSCs should provide furtherunderstanding of dental pulp progenitors and their potential use for new therapeutic approaches in regenerative medicine. Keywords: Human dental pulp stem cells (HDPSCs), Differentiation, Bioactive factors, Inductive factors.

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Published
2018-04-22
How to Cite
1.
Mohammadi Golrang E, Dibaji F, Bahrami N, Mohammadi Golrang A. Human dental pulp stem cells differentiation: A review. jcr. 5(1):1-.
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Review Article(s)