Prevalence of autoimmune thyroid disease in recurrent aphthous stomatitis
-
Shamsolmolouk Najafi
,
Arghavan Tonkaboni
,
Mohmmad Taghi Kiani
,
Mehrzad Gholampour Dehaki
,
Touraj Goli
Abstract
Introduction: Recurrent aphthous stomatitis (RAS) is a multifactorial recurrent oral lesion which is an autoimmune disease. TH1 cytokines are the most important etiological factors. Autoimmune thyroid disease (ATD) is one of the most common autoimmune diseases and generally coexists with other autoimmune diseases. This study assessed the prevalence of thyroid disease in patients with recurrent aphthous stomatitis. Materials and Methods: This case control study assessed 100 patients with RAS. Oral medicine specialists diagnosed RAS clinically; venous blood samples were analyzed for thyroid stimulating hormone (TSH), free triiodothyronine (fT3), total thyroxine (fT4), thyroglobulin, anti-thyroid peroxidase antibody (anti-TPO) and anti-thyroglobulin antibody (anti-TG) levels. Results: Fifty patients with RAS aged between 18-42 years (28.5±5.8) and 50 healthy volunteers aged 19-45 years (27.3±5.4) participated. In RAS patients, fT3 and TSH levels were significantly higher (P=0.031, P=0.706); however, fT4 level was lower in the RAS group (P=0.447). Anti TG and anti-TPO levels were significantly higher in the RAS group (P=0.008, P=0.067). Conclusion: Our study showed that ATD prevalence was significantly higher in RAS patients. Based on this study, we recommend assessment of thyroid hormones and antibodies in RAS patients.
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[11] Scully C, Gorsky M, Lozada-Nur F. Aphthous ulcerations. Dermatol Ther 2002; 15: 185–205.
]12[Casiglia JM. Recurrent aphthous stomatitis: etiology, diagnosis, and treatment. Gen Dent 2002; 50:157–166.
[13] Drugarin D, Negru S, Koreck A et al. The pattern of a T(H)1 cytokine in autoimmune thyroiditis.Immunol Lett 2000; 71: 73–77.
[14] Karanikas G, Schuetz M, Wahl K et al. Relation of anti-TPO autoantibody titre and T-lymphocyte cytokine production patterns in Hashimoto’s thyroiditis.Clin Endocrinol (Oxf) 2005; 63: 191–196.
[15] Hollowell JG, Staehling NW, Flanders WD et al.: Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey(NHANES III). J ClinEndocrinolMetab 2002; 87:489–99.
[2] Shulman JD. An exploration of point, annual, and lifetime prevalence in characterizing recurrent aphthous stomatitis in USA children and youths. J[3] Mahesh Chavan,Hansa Jain, Nikhil Diwan, ShivajiKhedkar,AnaghaShete, SachinDurkar. Recurrent aphthous stomatitis: a review. Oral PatholMed (2012) 41: 577–583.
[4] Akintoye SO, Greenberg MS. Recurrent aphthous stomatitis. Dent Clin North Am 2005; 49: 31–47.
[5] Ship JA, Chavez EM, Doerr PA, Henson BS, Sarmadi M. Recurrent aphthous stomatitis. QuintessenceInt 2000; 31: 95–112.
[6] Miller MF, Garfunkel AA, Ram CA, Ship II. The inheritance of recurrent aphthous stomatitis. Observations on susceptibility. Oral Surg Oral Med Oral Pathol 1980; 49: 409–12.
[7] Hoover CI, Olson JA, Greenspan JS. Humoral responses and cross-reactivity to viridans streptococci in recurrent aphthous ulceration. J Dent Res 1986; 65: 1101–4.
[8] Greenspan JS, Gadol N, Olson JA, et al. Lymphocyte function in recurrent aphthous ulceration. J Oral Pathol 1985; 14: 592–602.
[9] I.Y. Ozdemir, O. Calka, A.S. Karadag, N. Akdeniz, M. Ozturk Thyroid autoimmunity associated with recurrent aphthous stomatitis Journal of the European Academy of Dermatology (JEADV)2012, 26, 226–230.
[10] Motthias Schott. Warner A .scherbaum . Autoimmune Thyroid disease .Medicine .DtschArztebl 2006; 103(45): A 3023–32.
[11] Scully C, Gorsky M, Lozada-Nur F. Aphthous ulcerations. Dermatol Ther 2002; 15: 185–205.
]12[Casiglia JM. Recurrent aphthous stomatitis: etiology, diagnosis, and treatment. Gen Dent 2002; 50:157–166.
[13] Drugarin D, Negru S, Koreck A et al. The pattern of a T(H)1 cytokine in autoimmune thyroiditis.Immunol Lett 2000; 71: 73–77.
[14] Karanikas G, Schuetz M, Wahl K et al. Relation of anti-TPO autoantibody titre and T-lymphocyte cytokine production patterns in Hashimoto’s thyroiditis.Clin Endocrinol (Oxf) 2005; 63: 191–196.
[15] Hollowell JG, Staehling NW, Flanders WD et al.: Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey(NHANES III). J ClinEndocrinolMetab 2002; 87:489–99.
| Files | ||
| Issue | Vol 5, No 4 (Autumn 2018) | |
| Section | Original Article(s) | |
| Keywords | ||
| Recurrent aphthous stomatitis Thyroid autoimmune disease Thyroid hormone Thyroid antibodies | ||
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How to Cite
1.
Najafi S, Tonkaboni A, Kiani MT, Gholampour Dehaki M, Goli T. Prevalence of autoimmune thyroid disease in recurrent aphthous stomatitis. J Craniomaxillofac Res. 2019;5(4):164-168.
