Human dental pulp stem cells differentiation: A review
,
Abstract
The advent of regenerative medicine has brought us the opportunity to regenerate, modify and restore human organs function. Stem cells, a key resource in regenerative medicine, are defined as clonogenic, self-renewing, progenitor cells that can generate into one or more specialized cell types. Human dental pulp stem cells (HDPSCs) are ectodermal-derived stem cells, originating from migrating neural crest cells and are capable of providing enough cells for potential cell-basedtherapies. During last decade, HDPSCs have received extensive attention in the field of tissue engineering and regenerative medicine due to their accessibility and ability to differentiate in severalcell phenotypes. In this review, we have described the potential of HDPSCs to differentiate into odontoblasts, osteoblasts, hepatocytes, neuroblasts and angioblasts in response to different bioactive factors. Therefore, the culture and selective differentiation of HDPSCs should provide furtherunderstanding of dental pulp progenitors and their potential use for new therapeutic approaches in regenerative medicine. Keywords: Human dental pulp stem cells (HDPSCs), Differentiation, Bioactive factors, Inductive factors.
[1] Ahmed T, Hincke MT. Mesenchymal stem cellbased tissue engineering strategies for repair of articular cartilage. Histol Histopathol. 2014; 29(6):669-89.
[2] Brady E, Cannon A, Farrell F, Mc Caffrey G. Tissue engineering scaffold. Google Patents; 2002.
[3] Casagrande L, Cordeiro MM, Nor SA, Nor JE. Dental pulp stem cells in regenerative dentistry. Odontology. 2011; 99(1):1-7.
[4] Gronthos S, Brahim J, Li W, Fisher L, Cherman N, Boyde A, et al. Stem cell properties of human dental pulp stem cells. Journal of dental research.2002; 81(8):531-5.
[5] Zhang W, Walboomers XF, Shi S, Fan M, Jansen JA.Multilineage differentiation potential of stem cells derived from human dental pulp after cryopreservation.Tissue engineering. 2006; 12(10):2813-23.
[6] Jernvall J, Jung HS. Genotype, phenotype, and developmental biology of molar tooth characters.American journal of physical anthropology. 2000;113(S31):171-90.
[7] Jernvall J, Keranen SV, Thesleff I. Evolutionarymodification of development in mammalian teeth: quantifying gene expression patterns and topography.Proceedings of the National Academy ofSciences. 2000; 97(26):14444-8.
[8] Jernvall J, Thesleff I. Reiterative signaling and patterning during mammalian tooth morphogenesis.Mechanisms of development. 2000; 92(1):19-29.
[9] Bayat M, Bahrami N, Bayat H, Manafi Z, Daustany M, Mohamadnia A. Comparison the differentiate ability of wisdom tooth follicle stem cells intonerve and bone tissue. Journal of Applied TissueEngineering. 2017; 4(1):11-22.
[10] Ledesma-Martinez E, Mendoza-Nunez VM, Santiago-Osorio E. Mesenchymal stem cells derivedfrom dental pulp: a review. Stem cells international.2016;2016.
[11] Sedgley CM, Botero TM. Dental stem cells and their sources. Dental Clinics. 2012; 56(3):549-61.
[12] Tachibana R, Tatehara S, Kumasaka S, Tokuyama R, Satomura K. Effect of melatonin on human dental papilla cells. International journal of molecular sciences. 2014; 15(10):17304-17.
[13] Liu H, Gronthos S, Shi S. Dental pulp stem cells.Methods in enzymology. 419: Elsevier; 2006. p.99-113.
[14] Yan M, Yu Y, Zhang G, Tang C, Yu J. A journey from dental pulp stem cells to a bio-tooth. Stem Cell Reviews and Reports. 2011; 7(1):161-71.
[15] Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs)in vitro and in vivo. Proceedings of the National Academy of Sciences. 2000; 97(25):13625-30.
[16] Miura M, Gronthos S, Zhao M, Lu B, Fisher LW,Robey PG, et al. SHED: stem cells from human exfoliated deciduous teeth. Proceedings of the National Academy of Sciences. 2003; 100(10):5807-12.
[17] Wang X, Sha X-J, Li G-H, Yang F-S, Ji K, Wen L-Y,et al. Comparative characterization of stem cells from human exfoliated deciduous teeth and dental pulp stem cells. Archives of oral biology. 2012;57(9):1231-40.
[18] Bakopoulou A, Leyhausen G, Volk J, TsiftsoglouA, Garefis P, Koidis P, et al. Comparative analysisof in vitro osteo/odontogenic differentiation potential of human dental pulp stem cells (DPSCs)and stem cells from the apical papilla (SCAP). Archives
of oral biology. 2011; 56(7):709-21.
[19] Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S,Shi S, et al. Characterization of the apical papillaand its residing stem cells from human immaturepermanent teeth: a pilot study. Journal of endodontics.2008; 34(2):166-71.
[20] Zou X-Y, Yang H-Y, Yu Z, Tan X-B, Yan X, HuangGT. Establishment of transgene-free induced pluripotentstem cells reprogrammed from humanstem cells of apical papilla for neural differentiation.Stem cell research & therapy. 2012; 3(5):43.
[21] Li S, Ma Z, Niu Z, Qian H, Xuan D, Hou R, et al.NASA-approved rotary bioreactor enhances proliferationand osteogenesis of human periodontalligament stem cells. Stem Cells and Development.2009; 18(9):1273-82.
[22] Liu Y, Zheng Y, Ding G, Fang D, Zhang C, BartoldPM, et al. Periodontal ligament stem cell‐mediated treatment for periodontitis in miniature swine.Stem cells. 2008; 26(4):1065-73.
[23] Wang L, Shen H, Zheng W, Tang L, Yang Z, Gao Y,et al. Characterization of stem cells from alveolar periodontal ligament. Tissue Engineering Part A.2010; 17(7-8):1015-26.
[24] Honda MJ, Imaizumi M, Tsuchiya S, Morsczeck C.Dental follicle stem cells and tissue engineering.Journal of oral science. 2010; 52(4):541-52.
[25] Morsczeck C. Dental Follicle Stem Cells. StemCell Biology and Tissue Engineering in DentalSciences: Elsevier; 2015. p. 271-7.
[26] Carini F, Menchini Fabris G, Biagi E, Salvade A,Sbordone L, Baldoni M. Estudio experimental sobrela utilizacion de celulas madre humanas en laterapia de los defectos periodontales: resultadospreliminares. Avances en periodoncia e implantologiaoral. 2011; 23(2):97-107.
[27] Zhang N, Li J, Wang J, Zhang H. The effect of bone marrow mesenchymal stem cell transplantation on diabetic cardiomyopathy. Zhonghua xinxue guan bing za zhi. 2008; 36(12):1115-9.
[28] Farsani MM, Bahrami N, Shojaei S. Gene therapy a new approach in dentistry: human or microbialgene modification. Journal of CraniomaxillofacialResearch. 2017; 4(3):383-6.
[29] Bahrami N, Manafi Z, Mohajeri F, MohamadniaA. Neural Differentiation Potential of Stem CellsDerived from Dental Follicle and Periodontal Ligament stem cells. Journal of Applied Tissue Engineering.2017; 4(1):1-10.
[30] Horwitz E, Le Blanc K, Dominici M, Mueller I,Slaper-Cortenbach I, Marini F, et al. Clarificationof the nomenclature for MSC: The InternationalSociety for Cellular Therapy position statement.Cytotherapy. 2005; 7(5):393-5.
[31] Dominici M, Le Blanc K, Mueller I, Slaper-CortenbachI, Marini F, Krause D, et al. Minimal criteriafor defining multipotent mesenchymal stromalcells. The International Society for CellularTherapy position statement. Cytotherapy. 2006;8(4):315-7.
[32] Feter Y, Afiana NS, Chandra JN, Abdullah K, ShafiraJ, Sandra F. Dental Mesenchymal Stem Cell:Its role in tooth development, types, surface antigensand differentiation potential. Molecular andCellular Biomedical Sciences. 2017; 1(2):50-7.
[33] Bahrami N, Gholami M, Jamaati HR, MohamadniaA, Dargahi H, Kazempour Dizaji M, et al. Expressionof two essential mRNA biomarker in theperipheral blood as possible biomarkers for diagnosisof non-small cell lung carcinoma. MinervaPneumologica. 2016; 55(3):31-6.
[34] Murray PE, Garcia-Godoy F, Hargreaves KM. Regenerativeendodontics: a review of current status and a call for action. Journal of endodontics. 2007;33(4):377-90.
[35] Bayat M, Shojaei S, Bahrami N, Mohamadnia AR,Shojaei P, Bahrami N. Protein engineering of recombinantHuman Bone Morphogenetic Protein2 with higher interaction with Ca phosphate basedscaffold usedfor osteogenesis. Journal of BiomedicalMaterials Research Part A. 2017.
[36] Kadkhoda Z, Safarpour A, Azmoodeh F, AdibiS, Khoshzaban A, Bahrami N. Histopathologicalcomparison between bone marrow-and periodontium-derived stem cells for bone regenerationin rabbit calvaria. International journal of organtransplantation medicine. 2016; 7(1):9.
[37] Maioli M, Basoli V, Santaniello S, Cruciani S, DelitalaAP, Pinna R, et al. Osteogenesis from DentalPulp Derived Stem Cells: A Novel ConditionedMedium Including Melatonin within a Mixtureof Hyaluronic, Butyric, and Retinoic Acids. Stemcells international. 2016; 2016.
[38] Mangano C, De Rosa A, Desiderio V, d’Aquino R,Piattelli A, De Francesco F, et al. The osteoblastic differentiation of dental pulp stem cells and bone formation on different titanium surface textures.Biomaterials. 2010; 31(13):3543-51.
[39] Lv T, Wu Y, Mu C, Liu G, Yan M, Xu X, et al.Insulin-like growth factor 1 promotes the proliferationand committed differentiation of human
dental pulp stem cells through MAPK pathways.Archives of oral biology. 2016; 72:116-23.
[40] Cooper PR, Takahashi Y, Graham LW, Simon S,Imazato S, Smith AJ. Inflammation–regenerationinterplay in the dentine–pulp complex. Journal ofdentistry. 2010; 38(9):687-97.
[41] Couble M-L, Farges J-C, Bleicher F, Perrat-Mabillon B, Boudeulle M, Magloire H. Odontoblast differentiationof human dental pulp cells in explant cultures. Calcified Tissue International. 2000;66(2):129-38.
[42] Liu Q, Fan W, He Y, Zhang F, Guan X, Deng Q,et al. Effects of melatonin on the proliferation anddifferentiation of human dental pulp cells. Archivesof oral biology. 2017; 83:33-9.
[43] He H, Yu J, Liu Y, Lu S, Liu H, Shi J, et al. Effectsof FGF2 and TGFβ1 on the differentiation of humandental pulp stem cells in vitro. Cell biologyinternational. 2008; 32(7):827-34.
[44] Laino G, d’Aquino R, Graziano A, Lanza V, Carinci F, Naro F, et al. A new population of human adult dental pulp stem cells: a useful source of livingautologous fibrous bone tissue (LAB). Journal ofbone and mineral research. 2005; 20(8):1394-402.
[45] Cho YA, Noh K, Jue SS, Lee SY, Kim EC. Melatoninpromotes hepatic differentiation of humandental pulp stem cells: clinical implications for theprevention of liver fibrosis. Journal of pineal research.2015; 58(1):127-35.
[46] Ishkitiev N, Calenic B, Aoyama I, Ii H, YaegakiK, Imai T. Hydrogen sulfide increases hepatic differentiation in tooth-pulp stem cells. Journal ofbreath research. 2012; 6(1):017103.
[47] Okada M, Ishkitiev N, Yaegaki K, Imai T, TanakaT, Fukuda M, et al. Hydrogen sulphide increaseshepatic differentiation of human tooth pulp stemcells compared with human bone marrow stemcells. International endodontic journal. 2014;47(12):1142-50.
[48] Chai Y, Jiang X, Ito Y, Bringas P, Han J, RowitchDH, et al. Fate of the mammalian cranial neuralcrest during tooth and mandibular morphogenesis.Development. 2000; 127(8):1671-9.
[49] Brar GS, Toor RSS. Dental stem cells: dentinogenic,osteogenic, and neurogenic differentiation andits clinical cell based therapies. Indian Journal ofDental Research. 2012; 23(3):393.
[50] Kiraly M, Porcsalmy B, Pataki A, Kadar K, JelitaiM, Molnar B, et al. Simultaneous PKC and cAMPactivation induces differentiation of human dentalpulp stem cells into functionally active neurons.Neurochemistry international. 2009; 55(5):323-32.
[51] Osathanon T, Nowwarote N, Pavasant P. Basic fibroblastgrowth factor inhibits mineralization butinduces neuronal differentiation by human dentalpulp stem cells through a FGFR and PLCγ signalingpathway. Journal of cellular biochemistry.2011; 112(7):1807-16.
[52] Chang C-C, Chang K-C, Tsai S-J, Chang H-H,Lin C-P. Neurogenic differentiation of dentalpulp stem cells to neuron-like cells in dopaminergicand motor neuronal inductive media. Journalof the Formosan Medical Association. 2014;113(12):956-65.
[53] Bronckaers A, Hilkens P, Fanton Y, Struys T, GervoisP, Politis C, et al. Angiogenic properties ofhuman dental pulp stem cells. PloS one. 2013;8(8):e71104.
[54] Gandia C, Arminan A, Garcia‐Verdugo JM, LledoE, Ruiz A, Minana MD, et al. Human dental pulpstem cells improve left ventricular function, induceangiogenesis, and reduce infarct size in ratswith acute myocardial infarction. Stem cells. 2008;26(3):638-45.
[55] Baum BJ, Mooney DJ. The impact of tissue engineeringon dentistry. The Journal of the AmericanDental Association. 2000; 131(3):309-18.
[56] Bahrami N, Bayat M, Mohamadnia A, Shojaee S,Bahrami N, editors. Protein Engineering. MOLECULARTHERAPY; 2017: CELL PRESS 50HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA02139 USA.
[57] Ai J, Bahrami N, Ai A, Mohamadnia A. DentalTissue Engineering. Artificial Organs. 2013.
[2] Brady E, Cannon A, Farrell F, Mc Caffrey G. Tissue engineering scaffold. Google Patents; 2002.
[3] Casagrande L, Cordeiro MM, Nor SA, Nor JE. Dental pulp stem cells in regenerative dentistry. Odontology. 2011; 99(1):1-7.
[4] Gronthos S, Brahim J, Li W, Fisher L, Cherman N, Boyde A, et al. Stem cell properties of human dental pulp stem cells. Journal of dental research.2002; 81(8):531-5.
[5] Zhang W, Walboomers XF, Shi S, Fan M, Jansen JA.Multilineage differentiation potential of stem cells derived from human dental pulp after cryopreservation.Tissue engineering. 2006; 12(10):2813-23.
[6] Jernvall J, Jung HS. Genotype, phenotype, and developmental biology of molar tooth characters.American journal of physical anthropology. 2000;113(S31):171-90.
[7] Jernvall J, Keranen SV, Thesleff I. Evolutionarymodification of development in mammalian teeth: quantifying gene expression patterns and topography.Proceedings of the National Academy ofSciences. 2000; 97(26):14444-8.
[8] Jernvall J, Thesleff I. Reiterative signaling and patterning during mammalian tooth morphogenesis.Mechanisms of development. 2000; 92(1):19-29.
[9] Bayat M, Bahrami N, Bayat H, Manafi Z, Daustany M, Mohamadnia A. Comparison the differentiate ability of wisdom tooth follicle stem cells intonerve and bone tissue. Journal of Applied TissueEngineering. 2017; 4(1):11-22.
[10] Ledesma-Martinez E, Mendoza-Nunez VM, Santiago-Osorio E. Mesenchymal stem cells derivedfrom dental pulp: a review. Stem cells international.2016;2016.
[11] Sedgley CM, Botero TM. Dental stem cells and their sources. Dental Clinics. 2012; 56(3):549-61.
[12] Tachibana R, Tatehara S, Kumasaka S, Tokuyama R, Satomura K. Effect of melatonin on human dental papilla cells. International journal of molecular sciences. 2014; 15(10):17304-17.
[13] Liu H, Gronthos S, Shi S. Dental pulp stem cells.Methods in enzymology. 419: Elsevier; 2006. p.99-113.
[14] Yan M, Yu Y, Zhang G, Tang C, Yu J. A journey from dental pulp stem cells to a bio-tooth. Stem Cell Reviews and Reports. 2011; 7(1):161-71.
[15] Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs)in vitro and in vivo. Proceedings of the National Academy of Sciences. 2000; 97(25):13625-30.
[16] Miura M, Gronthos S, Zhao M, Lu B, Fisher LW,Robey PG, et al. SHED: stem cells from human exfoliated deciduous teeth. Proceedings of the National Academy of Sciences. 2003; 100(10):5807-12.
[17] Wang X, Sha X-J, Li G-H, Yang F-S, Ji K, Wen L-Y,et al. Comparative characterization of stem cells from human exfoliated deciduous teeth and dental pulp stem cells. Archives of oral biology. 2012;57(9):1231-40.
[18] Bakopoulou A, Leyhausen G, Volk J, TsiftsoglouA, Garefis P, Koidis P, et al. Comparative analysisof in vitro osteo/odontogenic differentiation potential of human dental pulp stem cells (DPSCs)and stem cells from the apical papilla (SCAP). Archives
of oral biology. 2011; 56(7):709-21.
[19] Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S,Shi S, et al. Characterization of the apical papillaand its residing stem cells from human immaturepermanent teeth: a pilot study. Journal of endodontics.2008; 34(2):166-71.
[20] Zou X-Y, Yang H-Y, Yu Z, Tan X-B, Yan X, HuangGT. Establishment of transgene-free induced pluripotentstem cells reprogrammed from humanstem cells of apical papilla for neural differentiation.Stem cell research & therapy. 2012; 3(5):43.
[21] Li S, Ma Z, Niu Z, Qian H, Xuan D, Hou R, et al.NASA-approved rotary bioreactor enhances proliferationand osteogenesis of human periodontalligament stem cells. Stem Cells and Development.2009; 18(9):1273-82.
[22] Liu Y, Zheng Y, Ding G, Fang D, Zhang C, BartoldPM, et al. Periodontal ligament stem cell‐mediated treatment for periodontitis in miniature swine.Stem cells. 2008; 26(4):1065-73.
[23] Wang L, Shen H, Zheng W, Tang L, Yang Z, Gao Y,et al. Characterization of stem cells from alveolar periodontal ligament. Tissue Engineering Part A.2010; 17(7-8):1015-26.
[24] Honda MJ, Imaizumi M, Tsuchiya S, Morsczeck C.Dental follicle stem cells and tissue engineering.Journal of oral science. 2010; 52(4):541-52.
[25] Morsczeck C. Dental Follicle Stem Cells. StemCell Biology and Tissue Engineering in DentalSciences: Elsevier; 2015. p. 271-7.
[26] Carini F, Menchini Fabris G, Biagi E, Salvade A,Sbordone L, Baldoni M. Estudio experimental sobrela utilizacion de celulas madre humanas en laterapia de los defectos periodontales: resultadospreliminares. Avances en periodoncia e implantologiaoral. 2011; 23(2):97-107.
[27] Zhang N, Li J, Wang J, Zhang H. The effect of bone marrow mesenchymal stem cell transplantation on diabetic cardiomyopathy. Zhonghua xinxue guan bing za zhi. 2008; 36(12):1115-9.
[28] Farsani MM, Bahrami N, Shojaei S. Gene therapy a new approach in dentistry: human or microbialgene modification. Journal of CraniomaxillofacialResearch. 2017; 4(3):383-6.
[29] Bahrami N, Manafi Z, Mohajeri F, MohamadniaA. Neural Differentiation Potential of Stem CellsDerived from Dental Follicle and Periodontal Ligament stem cells. Journal of Applied Tissue Engineering.2017; 4(1):1-10.
[30] Horwitz E, Le Blanc K, Dominici M, Mueller I,Slaper-Cortenbach I, Marini F, et al. Clarificationof the nomenclature for MSC: The InternationalSociety for Cellular Therapy position statement.Cytotherapy. 2005; 7(5):393-5.
[31] Dominici M, Le Blanc K, Mueller I, Slaper-CortenbachI, Marini F, Krause D, et al. Minimal criteriafor defining multipotent mesenchymal stromalcells. The International Society for CellularTherapy position statement. Cytotherapy. 2006;8(4):315-7.
[32] Feter Y, Afiana NS, Chandra JN, Abdullah K, ShafiraJ, Sandra F. Dental Mesenchymal Stem Cell:Its role in tooth development, types, surface antigensand differentiation potential. Molecular andCellular Biomedical Sciences. 2017; 1(2):50-7.
[33] Bahrami N, Gholami M, Jamaati HR, MohamadniaA, Dargahi H, Kazempour Dizaji M, et al. Expressionof two essential mRNA biomarker in theperipheral blood as possible biomarkers for diagnosisof non-small cell lung carcinoma. MinervaPneumologica. 2016; 55(3):31-6.
[34] Murray PE, Garcia-Godoy F, Hargreaves KM. Regenerativeendodontics: a review of current status and a call for action. Journal of endodontics. 2007;33(4):377-90.
[35] Bayat M, Shojaei S, Bahrami N, Mohamadnia AR,Shojaei P, Bahrami N. Protein engineering of recombinantHuman Bone Morphogenetic Protein2 with higher interaction with Ca phosphate basedscaffold usedfor osteogenesis. Journal of BiomedicalMaterials Research Part A. 2017.
[36] Kadkhoda Z, Safarpour A, Azmoodeh F, AdibiS, Khoshzaban A, Bahrami N. Histopathologicalcomparison between bone marrow-and periodontium-derived stem cells for bone regenerationin rabbit calvaria. International journal of organtransplantation medicine. 2016; 7(1):9.
[37] Maioli M, Basoli V, Santaniello S, Cruciani S, DelitalaAP, Pinna R, et al. Osteogenesis from DentalPulp Derived Stem Cells: A Novel ConditionedMedium Including Melatonin within a Mixtureof Hyaluronic, Butyric, and Retinoic Acids. Stemcells international. 2016; 2016.
[38] Mangano C, De Rosa A, Desiderio V, d’Aquino R,Piattelli A, De Francesco F, et al. The osteoblastic differentiation of dental pulp stem cells and bone formation on different titanium surface textures.Biomaterials. 2010; 31(13):3543-51.
[39] Lv T, Wu Y, Mu C, Liu G, Yan M, Xu X, et al.Insulin-like growth factor 1 promotes the proliferationand committed differentiation of human
dental pulp stem cells through MAPK pathways.Archives of oral biology. 2016; 72:116-23.
[40] Cooper PR, Takahashi Y, Graham LW, Simon S,Imazato S, Smith AJ. Inflammation–regenerationinterplay in the dentine–pulp complex. Journal ofdentistry. 2010; 38(9):687-97.
[41] Couble M-L, Farges J-C, Bleicher F, Perrat-Mabillon B, Boudeulle M, Magloire H. Odontoblast differentiationof human dental pulp cells in explant cultures. Calcified Tissue International. 2000;66(2):129-38.
[42] Liu Q, Fan W, He Y, Zhang F, Guan X, Deng Q,et al. Effects of melatonin on the proliferation anddifferentiation of human dental pulp cells. Archivesof oral biology. 2017; 83:33-9.
[43] He H, Yu J, Liu Y, Lu S, Liu H, Shi J, et al. Effectsof FGF2 and TGFβ1 on the differentiation of humandental pulp stem cells in vitro. Cell biologyinternational. 2008; 32(7):827-34.
[44] Laino G, d’Aquino R, Graziano A, Lanza V, Carinci F, Naro F, et al. A new population of human adult dental pulp stem cells: a useful source of livingautologous fibrous bone tissue (LAB). Journal ofbone and mineral research. 2005; 20(8):1394-402.
[45] Cho YA, Noh K, Jue SS, Lee SY, Kim EC. Melatoninpromotes hepatic differentiation of humandental pulp stem cells: clinical implications for theprevention of liver fibrosis. Journal of pineal research.2015; 58(1):127-35.
[46] Ishkitiev N, Calenic B, Aoyama I, Ii H, YaegakiK, Imai T. Hydrogen sulfide increases hepatic differentiation in tooth-pulp stem cells. Journal ofbreath research. 2012; 6(1):017103.
[47] Okada M, Ishkitiev N, Yaegaki K, Imai T, TanakaT, Fukuda M, et al. Hydrogen sulphide increaseshepatic differentiation of human tooth pulp stemcells compared with human bone marrow stemcells. International endodontic journal. 2014;47(12):1142-50.
[48] Chai Y, Jiang X, Ito Y, Bringas P, Han J, RowitchDH, et al. Fate of the mammalian cranial neuralcrest during tooth and mandibular morphogenesis.Development. 2000; 127(8):1671-9.
[49] Brar GS, Toor RSS. Dental stem cells: dentinogenic,osteogenic, and neurogenic differentiation andits clinical cell based therapies. Indian Journal ofDental Research. 2012; 23(3):393.
[50] Kiraly M, Porcsalmy B, Pataki A, Kadar K, JelitaiM, Molnar B, et al. Simultaneous PKC and cAMPactivation induces differentiation of human dentalpulp stem cells into functionally active neurons.Neurochemistry international. 2009; 55(5):323-32.
[51] Osathanon T, Nowwarote N, Pavasant P. Basic fibroblastgrowth factor inhibits mineralization butinduces neuronal differentiation by human dentalpulp stem cells through a FGFR and PLCγ signalingpathway. Journal of cellular biochemistry.2011; 112(7):1807-16.
[52] Chang C-C, Chang K-C, Tsai S-J, Chang H-H,Lin C-P. Neurogenic differentiation of dentalpulp stem cells to neuron-like cells in dopaminergicand motor neuronal inductive media. Journalof the Formosan Medical Association. 2014;113(12):956-65.
[53] Bronckaers A, Hilkens P, Fanton Y, Struys T, GervoisP, Politis C, et al. Angiogenic properties ofhuman dental pulp stem cells. PloS one. 2013;8(8):e71104.
[54] Gandia C, Arminan A, Garcia‐Verdugo JM, LledoE, Ruiz A, Minana MD, et al. Human dental pulpstem cells improve left ventricular function, induceangiogenesis, and reduce infarct size in ratswith acute myocardial infarction. Stem cells. 2008;26(3):638-45.
[55] Baum BJ, Mooney DJ. The impact of tissue engineeringon dentistry. The Journal of the AmericanDental Association. 2000; 131(3):309-18.
[56] Bahrami N, Bayat M, Mohamadnia A, Shojaee S,Bahrami N, editors. Protein Engineering. MOLECULARTHERAPY; 2017: CELL PRESS 50HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA02139 USA.
[57] Ai J, Bahrami N, Ai A, Mohamadnia A. DentalTissue Engineering. Artificial Organs. 2013.
| Files | ||
| Issue | Vol 5, No 1 (Winter 2018) | |
| Section | Review Article(s) | |
| Keywords | ||
| Human dental pulp stem cells (HDPSCs) Differentiation Bioactive factors Inductive factors. | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Mohammadi Golrang E, Dibaji F, Bahrami N, Mohammadi Golrang A. Human dental pulp stem cells differentiation: A review. J Craniomaxillofac Res. 2018;5(1):1-7.
