Prevalence of autoimmune thyroid disease in recurrent aphthous stomatitis

  • Shamsolmolouk Najafi Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Arghavan Tonkaboni Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Mohmmad Taghi Kiani Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mehrzad Gholampour Dehaki Department of Internal Medicine, School of Medicine, Aja University of Medical Sciences, Tehran, Iran.
  • Touraj Goli Dentist, School of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
Recurrent aphthous stomatitis, Thyroid autoimmune disease, Thyroid hormone, Thyroid antibodies


Introduction: Recurrent aphthous stomatitis (RAS) is a multifactorial recurrent oral lesion which is an autoimmune disease. TH1 cytokines are the most important etiological factors. Autoimmune thyroid disease (ATD) is one of the most common autoimmune diseases and generally coexists with other autoimmune diseases. This study assessed the prevalence of thyroid disease in patients with recurrent aphthous stomatitis. Materials and Methods: This case control study assessed 100 patients with RAS. Oral medicine specialists diagnosed RAS clinically; venous blood samples were analyzed for thyroid stimulating hormone (TSH), free triiodothyronine (fT3), total thyroxine (fT4), thyroglobulin, anti-thyroid peroxidase antibody (anti-TPO) and anti-thyroglobulin antibody (anti-TG) levels. Results: Fifty patients with RAS aged between 18-42 years (28.5±5.8) and 50 healthy volunteers aged 19-45 years (27.3±5.4) participated. In RAS patients, fT3 and TSH levels were significantly higher (P=0.031, P=0.706); however, fT4 level was lower in the RAS group (P=0.447). Anti TG and anti-TPO levels were significantly higher in the RAS group (P=0.008, P=0.067). Conclusion: Our study showed that ATD prevalence was significantly higher in RAS patients. Based on this study, we recommend assessment of thyroid hormones and antibodies in RAS patients.


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How to Cite
Najafi S, Tonkaboni A, Kiani MT, Gholampour Dehaki M, Goli T. Prevalence of autoimmune thyroid disease in recurrent aphthous stomatitis. J Craniomaxillofac Res. 5(4):164-168.
Original Article(s)