Comparison of the clinical efficacy of celebrex and celecoxib for pain relief after periodontal surgeries
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Abstract
Background: Currently one of the most common problems in dentistry is effective pain management after dental surgeries. Celecoxib is the only specific COX-2 inhibitor used in Iran. Aim: The aim of this study was to determine the effectiveness of Celecoxib (an Iranian product) and Celebrex in pain relief after periodontal surgery. Materials and Methods: This randomized double-blind cross-over clinical trial was conducted on 30 patients with chronic periodontitis. The patients underwent surgical procedures on two posterior symmetric sextant with a 4-week interval. The patients were assigned to 2 groups: Group A: 200mg of Celebrex under the brand name, (bid) and group B:200 mg of Celecoxib (bid). The patients reported their pain level using VAS (visual analog scale) 1, 3, 6, 12, 24 and 48 hours after periodontal surgery. Data were analyzed with SPSS 15, using Mann-Whitney and Freidman’s tests. Results: Statistical analysis of data showed significant differences between Celecoxib and Celebrex1, 3, 6, 12 and 24 hours after surgery (P<0.05). In each group there were significant differences between different postoperative intervals (P<0.05). Conclusion: Considering the lower rate of side effects of COX-2 specific inhibitors, if the patients have no financial problems, Celebrex can be a proper choice for pain management after periodontal surgeries. Keywords: Celecoxib; Cyclooxygenase-2 inhibitors; Pain management.
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pain after periodontal surgery. Journal of periodontology. 2006; 77(11):1809-14.
[3] Rashwan WA. The Efficacy of Acetaminophen–Caffeine Compared to Ibuprofen in the Control of Postoperative Pain After Periodontal Surgery: A Crossover Pilot Study. Journal of periodontology. 2009; 80(6):945-52.
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[5] Kianian F, Seifi B, Kadkhodaee M, Sajedyzadeh A, Ahghari P. Protective effects of celecoxib on ischemia reperfusion–induced acute kidney injury: comparing between male and female rats. Iranian Journal of Basic Medical Sciences. 2019; 22(1):43- 8.
[6] Veettil SK, Nathisuwan S, Ching SM, Jinatongthai P, Lim KG, Kew ST, et al. Efficacy and safety of celecoxib on the incidence of recurrent colorectal adenomas: a systematic review and meta-analysis. Cancer management and research. 2019; 11:561.
[7] Naseh M, Rezaie Kalat S. Comparison of the effects of celecoxib, naproxen and ibuprofen on pain control after periodontal surgeries. J Mash Dent Sch. 2011; 35(4):306-14.
[8] Haas DA. An update on analgesics for the management of acute postoperative dental pain. Journal-Canadian Dental Association. 2002; 68(8):476-84.
[9] Khan AA, Dionne RA. COX‐2 inhibitors for endodontic pain. Endodontic Topics. 2002; 3(1):31- 40.
[10] Dhondt L, Devreese M, Croubels S, De Baere S, Haesendonck R, Goessens T, et al. Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus). Scientific reports. 2017; 7(1):12043.
[11] Steffens JP, Santos FA, Pilatti GL. The Use of Etoricoxib and Celecoxib for Pain Prevention After Periodontal Surgery: A Double‐Masked, Parallel‐ Group, Placebo‐Controlled, Randomized Clinical Trial. Journal of periodontology. 2011; 82(9):1238-44.
[12] Steffens JP, Santos FA, Sartori R, Pilatti GL. Preemptive Dexamethasone and Etoricoxib for Pain and Discomfort Prevention After Periodontal Surgery: A Double‐Masked, Crossover, Controlled Clinical Trial. Journal of periodontology. 2010; 81(8):1153-60.
[13] Saatchi M, RAZAVI SM, Meskin M, Khouei M. Histopathologic study of the effect of celecoxib to control acute periapical inflammation after root canal treatment in cats. 2007.
[14] Popova C, Mlachkova A, Emilov D. Effectiveness of nsaids aulin and ibu-profen on the postoperative pain at gingival graft procedures–a pre-liminary studY. J IMAB. 2008; 2:12-5.
[15] Fricke J, Morrison BW, Fite S, Sandler M, Yuan W, Howard C, et al. MK‐966 versus naproxen sodium, 550 MG in post‐surgical dental pain. Clinical Pharmacology & Therapeutics. 1999; 65(2):119-.
[16] Azoubel M, Menezes A, Bezerra D, Oria R, Ribeiro R, Brito G. Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats. Brazilian journal of medical and biological research. 2007; 40(1):117-25.
and biological research. 2007; 40(1):117-25.
[2] Pilatti GL, Andre dos Santos F, Bianchi A, Cavassim R, Tozetto CW. The use of celecoxib and dexamethasone for the prevention and control of postoperative
pain after periodontal surgery. Journal of periodontology. 2006; 77(11):1809-14.
[3] Rashwan WA. The Efficacy of Acetaminophen–Caffeine Compared to Ibuprofen in the Control of Postoperative Pain After Periodontal Surgery: A Crossover Pilot Study. Journal of periodontology. 2009; 80(6):945-52.
[4] Giorgetti APO, Matos Rd, Casarin RCV, Pimentel SP, Cirano FR, Ribeiro FV. Preemptive and Postoperative Medication Protocols for Root Coverage Combined with Connective Tissue Graft. Brazilian dental journal. 2018; 29(1):23-9.
[5] Kianian F, Seifi B, Kadkhodaee M, Sajedyzadeh A, Ahghari P. Protective effects of celecoxib on ischemia reperfusion–induced acute kidney injury: comparing between male and female rats. Iranian Journal of Basic Medical Sciences. 2019; 22(1):43- 8.
[6] Veettil SK, Nathisuwan S, Ching SM, Jinatongthai P, Lim KG, Kew ST, et al. Efficacy and safety of celecoxib on the incidence of recurrent colorectal adenomas: a systematic review and meta-analysis. Cancer management and research. 2019; 11:561.
[7] Naseh M, Rezaie Kalat S. Comparison of the effects of celecoxib, naproxen and ibuprofen on pain control after periodontal surgeries. J Mash Dent Sch. 2011; 35(4):306-14.
[8] Haas DA. An update on analgesics for the management of acute postoperative dental pain. Journal-Canadian Dental Association. 2002; 68(8):476-84.
[9] Khan AA, Dionne RA. COX‐2 inhibitors for endodontic pain. Endodontic Topics. 2002; 3(1):31- 40.
[10] Dhondt L, Devreese M, Croubels S, De Baere S, Haesendonck R, Goessens T, et al. Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus). Scientific reports. 2017; 7(1):12043.
[11] Steffens JP, Santos FA, Pilatti GL. The Use of Etoricoxib and Celecoxib for Pain Prevention After Periodontal Surgery: A Double‐Masked, Parallel‐ Group, Placebo‐Controlled, Randomized Clinical Trial. Journal of periodontology. 2011; 82(9):1238-44.
[12] Steffens JP, Santos FA, Sartori R, Pilatti GL. Preemptive Dexamethasone and Etoricoxib for Pain and Discomfort Prevention After Periodontal Surgery: A Double‐Masked, Crossover, Controlled Clinical Trial. Journal of periodontology. 2010; 81(8):1153-60.
[13] Saatchi M, RAZAVI SM, Meskin M, Khouei M. Histopathologic study of the effect of celecoxib to control acute periapical inflammation after root canal treatment in cats. 2007.
[14] Popova C, Mlachkova A, Emilov D. Effectiveness of nsaids aulin and ibu-profen on the postoperative pain at gingival graft procedures–a pre-liminary studY. J IMAB. 2008; 2:12-5.
[15] Fricke J, Morrison BW, Fite S, Sandler M, Yuan W, Howard C, et al. MK‐966 versus naproxen sodium, 550 MG in post‐surgical dental pain. Clinical Pharmacology & Therapeutics. 1999; 65(2):119-.
[16] Azoubel M, Menezes A, Bezerra D, Oria R, Ribeiro R, Brito G. Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats. Brazilian journal of medical and biological research. 2007; 40(1):117-25.
and biological research. 2007; 40(1):117-25.
| Files | ||
| Issue | Vol 6, No 2 (Spring 2019) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/jcr.v6i2.2263 | |
| Keywords | ||
| Celecoxib Cyclooxygenase-2 inhibitors Pain management | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Naseh MR, Mirkeshavarz M, Jafary Z. Comparison of the clinical efficacy of celebrex and celecoxib for pain relief after periodontal surgeries. J Craniomaxillofac Res. 2019;6(2):55-59.
