Malignant transformation of leiomyoma of the mandible into leiomyosarcoma: A case report
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Abstract
Leiomyosarcoma (LMS) is an uncommon malignant spindle cell tumor of the head and neck region. It is extremely rare in the oral cavity that arises from smooth muscle differentiation. It may arise as primary, radiation-associated, or metastatic tumor. The clinical appearance of these tumors can be deceptively benign and can be mistaken for non-malignant conditions. Here We present a case with atypical leiomyoma of the mandible in a 40-year- old man who referred with complaint of pain and swelling in his jaw. He underwent surgery and histology and immonohistochemestery studies confirmed the diagnosis. After 6 months recurrence occurred. Histologic examination confirmed leiomyosarcoma so he was managed with surgical excision followed by radiotherapy and chemotherapy without any recurrence or metastasis after 2 years of follow-up. Keywords: Leiomyosarcoma; Mandible; Spindle cell tumor.
1. Schenberg ME, Slootweg PJ, Koole R. Leiomyosarcoma of the oral cavity. Report of four cases and review of the literature. J Craniomaxillofac Surg 1993; 21:342-7.
2. Yadav J, Bakshi J, Chouhan M and Modi R. Head and neck leiomyosarcoma. Indian J Otolaryngol Head Neck Surg 2013; 65: S1-S5.
3. Sharma R, et al. Oropharyngeal leiomyosarcoma. Ind J Otolaryngol Head Neck Surg. 2004; 56(3):230–232.
4. Bishwajit M, Fatema S, Sanjay J, Nidhi S, Sonal S, Ankur B. Leiomyosarcoma of mandible: A case report and review of literature. Int. Journal of Contemporary Dentistry. 2010; 1:58–63.
5 Ethunandan M, Stokes C, Higgins B, Spedding A, Way C and Brennan P. Primary oral leiomyo- sarcoma: A clinico-pathologic study and analysis of prognostic factors. Int J Oral Maxillofac Surg 2007; 36: 409-416.
6. Somerhausen N, Fletcher CD. Leiomyosarcoma of soft tissue in children: Clinicopathologic analysis of 20 cases. Am J Surg Pathol 1999; 23:755-63.
7. Bharambe BM, Deshpande KA, Sanjay G, et al. Malignant Transformation of Leiomyoma of Uterus to Leiomyosarcoma with Metastasis to Ovary J Obstet Gynaecol India. 2014 Feb; 64(1): 68-69doi: 10.1007/s13224-012-0202-4
8. Croce A, Moretti A, Laus M, Crescenzi D. Leiomyosarcoma of the base of the tongue and free edge of the epiglottis: A case report. J Med Case Rep 2012; 6:400.
9. Luaces Rey R, Lorenzo Franco F, Gómez Oliveira G, Patiño Seijas B, Guitián D, López-Cedrún Cembranos JL. Oral leiomyoma in retromolar trigone. A case report. Med Oral Patol Oral Cir Bucal 2007;12:E53-5.
10. Verma M, Lal P. Leiomyosarcoma of tongue: A case report and review of literature Asian Journal of Oncology / Jul-Dec 2016 / Volume 2 / Issue 2 82-84.
10.4103/2454-6798.197376
11. Deepak Kumar J Nagpal, Prashant R Prabhu, Amisha Shah, Sangeeta Palaskar
Leimyosarcoma of the buccal mucosa and review of literature
J Oral Maxillofac Pathol. 2013 Jan-Apr; 17(1): 149. doi: 10.4103/0973-029X.110732
12. Yan B, Li Y, Pan J, Xia H and Li LJ. Primary oral leiomyosarcoma: a retrospective clinical analy- sis of 20 cases. Oral Dis 2010; 16: 198-203.
13. Leiomyosarcoma of the mandibular canal. Possible differential diagnosis of cystic processes of the mandible].Ayad W, Dieckmann J, Freitag P, Wierich W Mund Kiefer Gesichtschir. 1998 Jan; 2(1):42-3
14. Nikitakis NG, Lopes MA, Bailey JS, Blanchaert RH, Jr, Ord RA, Sauk JJ. Oral leiomyosarcoma: Review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of IHC and molecular markers. Oral Oncol. 2002;38:201–8.
15. Allen, C.M., Nerville, B., Damm, D.D. and Marsh, W.: Leiomyosarcoma metastatic to the oral region. Re- port of three cases. Oral Surg., 76, 752-756 (1993).
16. Tsounias, B.: Metastatic uterine tumor to the oral cavity: case report and 20-year review of the English lit- erature. Ann. Dent., 47,26-27 (1988).
17. Leiomyosarcomas of the oral cavity: an unusual topographic subset easily mistaken for nonmesenchymal tumours. Dry SM, Jorgensen JL, Fletcher CD Histopathology. 2000 Mar; 36(3):210-20.
18. Fasanmade AW, Newman L. Primary leimyosarcoma of oral cavity: a case report and review of literature. Can J Plast Surg. 2002; 10:113–6.
19.Krishnan V, Miyaji C, Mainous E. Leiomyosarcoma of the mandible: case report. J Oral Maxillofac Surg 1991; 49: 652–5.
20. Leiomyosarcoma of the oral cavity: Report of seven cases and review of literature H. Amarapala a, W.M. Tilakaratne Oral Oncology EXTRA (2006) 42, 14–17 doi:10.1016/j.ooe.2005.08.001
21. Parker WH, Fu YS, Berek JS. Uterine sarcoma in patients operated on for presumed leiomyoma and rapidly growing leiomyoma. Obstet Gynecol. 1994; 83:414–8.
22. Leiomyosarcoma of the buccal mucosa: a case report with immunohistochemistry findings.
Yadav R, Bharathan S J Oral Sci. 2008 Jun; 50(2):215-8.
23. Hashimoto H, Daimaru Y, Tsuneyoshi M, Enjoji M. Leiomyosarcoma of the external soft tissues. A clinicopathologic, immunohistochemical, and electron microscopic study. Cancer 1986; 57:2077-88.
24. Ahn JH, Mirza T, Ameerally P. Leiomyosarcoma of the tongue with multiple metastases: A case report and review of literature. J Oral Maxillofac Surg 2012; 70:1745-50.
25. Enzinger FM, Weiss SW. Soft Tissue Tumors. 2nd ed. New Delhi: BI Publications; 1988. Leiomyosarcoma; pp. 402–21.
26. Schutz A, Smeets R, Driemel O, Hakim SG, Kosmehl H, Hanken H and Kolk A. Primary and secondary leiomyosarcoma of the oral and perioral region-clinicopathological and immu- nohistochemical analysis of a rare entity with a review of the literature. J Oral Maxillofac Surg 2013; 71: 1132-1142.
27. Willers H, Hug EB, Spiro IJ, Efird JT, Rosenberg AE, Wang CC. Adult soft tissue sarcomas of the head and neck treated by radiation and surgery or radiation alone: Patterns of failure and prognostic factors. Int J Radiat Oncol Biol Phys. 1995;33:585–93.
28. Leiomyosarcoma of the buccal mucosa: a case report with immunohistochemistry findings.Yadav R, Bharathan S J Oral Sci. 2008 Jun; 50(2):215-8.
2. Yadav J, Bakshi J, Chouhan M and Modi R. Head and neck leiomyosarcoma. Indian J Otolaryngol Head Neck Surg 2013; 65: S1-S5.
3. Sharma R, et al. Oropharyngeal leiomyosarcoma. Ind J Otolaryngol Head Neck Surg. 2004; 56(3):230–232.
4. Bishwajit M, Fatema S, Sanjay J, Nidhi S, Sonal S, Ankur B. Leiomyosarcoma of mandible: A case report and review of literature. Int. Journal of Contemporary Dentistry. 2010; 1:58–63.
5 Ethunandan M, Stokes C, Higgins B, Spedding A, Way C and Brennan P. Primary oral leiomyo- sarcoma: A clinico-pathologic study and analysis of prognostic factors. Int J Oral Maxillofac Surg 2007; 36: 409-416.
6. Somerhausen N, Fletcher CD. Leiomyosarcoma of soft tissue in children: Clinicopathologic analysis of 20 cases. Am J Surg Pathol 1999; 23:755-63.
7. Bharambe BM, Deshpande KA, Sanjay G, et al. Malignant Transformation of Leiomyoma of Uterus to Leiomyosarcoma with Metastasis to Ovary J Obstet Gynaecol India. 2014 Feb; 64(1): 68-69doi: 10.1007/s13224-012-0202-4
8. Croce A, Moretti A, Laus M, Crescenzi D. Leiomyosarcoma of the base of the tongue and free edge of the epiglottis: A case report. J Med Case Rep 2012; 6:400.
9. Luaces Rey R, Lorenzo Franco F, Gómez Oliveira G, Patiño Seijas B, Guitián D, López-Cedrún Cembranos JL. Oral leiomyoma in retromolar trigone. A case report. Med Oral Patol Oral Cir Bucal 2007;12:E53-5.
10. Verma M, Lal P. Leiomyosarcoma of tongue: A case report and review of literature Asian Journal of Oncology / Jul-Dec 2016 / Volume 2 / Issue 2 82-84.
10.4103/2454-6798.197376
11. Deepak Kumar J Nagpal, Prashant R Prabhu, Amisha Shah, Sangeeta Palaskar
Leimyosarcoma of the buccal mucosa and review of literature
J Oral Maxillofac Pathol. 2013 Jan-Apr; 17(1): 149. doi: 10.4103/0973-029X.110732
12. Yan B, Li Y, Pan J, Xia H and Li LJ. Primary oral leiomyosarcoma: a retrospective clinical analy- sis of 20 cases. Oral Dis 2010; 16: 198-203.
13. Leiomyosarcoma of the mandibular canal. Possible differential diagnosis of cystic processes of the mandible].Ayad W, Dieckmann J, Freitag P, Wierich W Mund Kiefer Gesichtschir. 1998 Jan; 2(1):42-3
14. Nikitakis NG, Lopes MA, Bailey JS, Blanchaert RH, Jr, Ord RA, Sauk JJ. Oral leiomyosarcoma: Review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of IHC and molecular markers. Oral Oncol. 2002;38:201–8.
15. Allen, C.M., Nerville, B., Damm, D.D. and Marsh, W.: Leiomyosarcoma metastatic to the oral region. Re- port of three cases. Oral Surg., 76, 752-756 (1993).
16. Tsounias, B.: Metastatic uterine tumor to the oral cavity: case report and 20-year review of the English lit- erature. Ann. Dent., 47,26-27 (1988).
17. Leiomyosarcomas of the oral cavity: an unusual topographic subset easily mistaken for nonmesenchymal tumours. Dry SM, Jorgensen JL, Fletcher CD Histopathology. 2000 Mar; 36(3):210-20.
18. Fasanmade AW, Newman L. Primary leimyosarcoma of oral cavity: a case report and review of literature. Can J Plast Surg. 2002; 10:113–6.
19.Krishnan V, Miyaji C, Mainous E. Leiomyosarcoma of the mandible: case report. J Oral Maxillofac Surg 1991; 49: 652–5.
20. Leiomyosarcoma of the oral cavity: Report of seven cases and review of literature H. Amarapala a, W.M. Tilakaratne Oral Oncology EXTRA (2006) 42, 14–17 doi:10.1016/j.ooe.2005.08.001
21. Parker WH, Fu YS, Berek JS. Uterine sarcoma in patients operated on for presumed leiomyoma and rapidly growing leiomyoma. Obstet Gynecol. 1994; 83:414–8.
22. Leiomyosarcoma of the buccal mucosa: a case report with immunohistochemistry findings.
Yadav R, Bharathan S J Oral Sci. 2008 Jun; 50(2):215-8.
23. Hashimoto H, Daimaru Y, Tsuneyoshi M, Enjoji M. Leiomyosarcoma of the external soft tissues. A clinicopathologic, immunohistochemical, and electron microscopic study. Cancer 1986; 57:2077-88.
24. Ahn JH, Mirza T, Ameerally P. Leiomyosarcoma of the tongue with multiple metastases: A case report and review of literature. J Oral Maxillofac Surg 2012; 70:1745-50.
25. Enzinger FM, Weiss SW. Soft Tissue Tumors. 2nd ed. New Delhi: BI Publications; 1988. Leiomyosarcoma; pp. 402–21.
26. Schutz A, Smeets R, Driemel O, Hakim SG, Kosmehl H, Hanken H and Kolk A. Primary and secondary leiomyosarcoma of the oral and perioral region-clinicopathological and immu- nohistochemical analysis of a rare entity with a review of the literature. J Oral Maxillofac Surg 2013; 71: 1132-1142.
27. Willers H, Hug EB, Spiro IJ, Efird JT, Rosenberg AE, Wang CC. Adult soft tissue sarcomas of the head and neck treated by radiation and surgery or radiation alone: Patterns of failure and prognostic factors. Int J Radiat Oncol Biol Phys. 1995;33:585–93.
28. Leiomyosarcoma of the buccal mucosa: a case report with immunohistochemistry findings.Yadav R, Bharathan S J Oral Sci. 2008 Jun; 50(2):215-8.
| Files | ||
| Issue | Vol 6, No 4 (Autumn 2019) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/jcr.v6i4.3294 | |
| Keywords | ||
| Leiomyosarcoma Mandible Spindle cell tumor | ||
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How to Cite
1.
Fallahi Motlagh M, Janbaz Y, Mirzaei Z. Malignant transformation of leiomyoma of the mandible into leiomyosarcoma: A case report. J Craniomaxillofac Res. 2020;6(4):165-170.
