Case Report

Multiple superficial mucoceles on the lower lip of a patient with phenylketonuria: A case report

Abstract

This article reports a 13-year-old boy with phenylketonuria and multiple superficial mucoceles on his lower lip. Phenylketonuria (PKU) is a serious and rare genetic disorder that affects the levels of amino acids such as phenylalanine in the body. If left untreated, PKU can negatively affect mental function and cause retardation. Patients with PKU receive less oral examination compared to the normal population. Mucoceles are lesions formed by the accumulation of mucous of salivary glands in soft tissue by blockage or extravasation. Local trauma has been identified as the main cause of mucoceles development. Superficial mucoceles are rare in the lower lip. These patients need close oral and maxillofacial examination to find problems, which may be related to their systemic problem. Micro-marsupialization is a conservative therapeutic approach for management of pediatric oral mucoceles. Management of trauma in patients with mental retardation is an important issue. Keywords: Mucocele; Phenylketonuria; Genetic disorder; lower lip; Salivary gland.
1. Blau N. Genetics of Phenylketonuria: Then and Now. Human mutation. 2016;37(6):508-15.
2. Kilpatrick NM, Awang H, Wilcken B, Christodoulou J. The implication of phenylketonuria on oral health. Pediatric dentistry. 1999;21(7):433-7.
3. Ballikaya E, Yildiz Y, Sivri HS, Tokatli A, Dursun A, Olmez S, et al. Oral health status of children with phenylketonuria. Journal of pediatric endocrinology & metabolism : JPEM. 2020;33(3):361-5.
4. Chi AC, Lambert PR, 3rd, Richardson MS, Neville BW. Oral mucoceles: a clinicopathologic review of 1,824 cases, including unusual variants. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 2011;69(4):1086-93.
5. Mortazavi H KR, Baharvand M, Eshghpour M. Bilateral Symmetrical Mucocele of the Lower Lip: Report of a Rare Clinical Presentation. international journal of experimental dental science. 2014;3.
6. Singh-Hüsgen P, Meissner T, Bizhang M, Henrich B, Raab WH. Investigation of the oral status and microorganisms in children with phenylketonuria and type 1 diabetes. Clinical oral investigations. 2016;20(4):841-7.
7. Winter G MJ, Goose D. Prevalence of dental caries in phenylketonuric children. Caries research. 1974;8(3):256-66.
8. Baurmash HD. Mucoceles and ranulas. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 2003;61(3):369-78.
9. Essa E, Beltagy T, El Mekaky Y. Micro-marsupialization as a conservative therapeutic approach for management of pediatric oral mucoceles. Tanta Dental Journal. 2019;16(3):142-8.
10. Aldrigui JM dSP, Xavier FCA, Nunes FD, Bussadori SK, Wanderley MT. Mucocele of the lower lip in a 1-year-old child. Pediatric Dental Journal. 2010;20(1):95-8.
11. Mehler SJ MPGmSASTS-.
12. Stavljenic LV RZ, Cvoriscec D, Granic P, Mardesic D, Zaninovic M, et al. Changes in the composition of salivary amino acids, proteins and enzymes in children with phenylketonuria. Acta stomatologica Croatica. 1987;21(2):87-92.
Files
IssueVol 7, No 3 (Summer 2020) QRcode
SectionCase Report(s)
Published2020-12-26
DOI https://doi.org/10.18502/jcr.v7i3.5287
Keywords
Mucocele; Phenylketonuria; Genetic disorder; lower lip; Salivary gland.

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Alavi Namvar M, Rafieyan S, Fathi Afkari B. Multiple superficial mucoceles on the lower lip of a patient with phenylketonuria: A case report. J Craniomaxillofac Res. 2020;7(3):154-157.