Mesenchymal chondrosarcoma of the mandible: A case report
Abstract
Mesenchymal chondrosarcoma as an aggressive type of chondrosarcoma shows a characteristic biphasic histopathologic pattern. The head and neck region is included a high proportion of extra skeletal sites. Very rare examples of Mesenchymal Chondrosarcoma involving the mandible have been described. Based on fragmented or tiny specimens, the diagnosis of this lesion has been remained a challenge because the specimens may contain only one of the two neoplastic elements. We report a rare case of mesenchymal chondrosarcoma of the mandible in a 19 years old male with delaying in diagnosis due to massive extension of the tumor to the soft tissues. Keywords: Mesenchymal chondrosarcoma; Mandible; Neoplasm.
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2-Priyanka S, Anil S, Sujata S, Sanjay S. Mesenchymal chondrosarcoma of mandible: A rare case report and review. J Oral Maxillofac Pathol. 2014 Sep; 18(Suppl 1): S167–S170.
3-Jaetli V, Gupta S.Mesenchymal chondrosarcoma of maxilla: a rare case report. Med Oral Patol Oral Cir Bucal. 2011 Jul 1;16(4):e493-6.
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9- Angiero, Francesca; Vinci, Raffaele; Sidoni, Angelo; Stefani, Michele. Mesenchymal chondrosarcoma of the left coronoid process: Report of a unique case with clinical, histopathologic, and immunohistochemical findings, and a review of the literature. Quintessence International . Apr2007, Vol. 38 Issue 4, p349-355. 7p. 9 Color Photographs, 1 Black and White Photograph, 1 Chart.
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11- Dobin SM, Donner LR, Speights VO Jr.Mesenchymal chondrosarcoma A cytogenetic, immunohistochemical and ultrastructural study. Cancer Genet Cytogenet. 1995 Aug;83(1):56-60.
12- Salehipour M, Hosseinzadeh M, Molaei Sisakhti A, Abdol Mohammadi Parvin V, Sadraei A, and Adib A.Renal Extra Skeletal Mesenchymal Chondrosarcoma: A Case Report. Urol Case Rep. 2017 May; 12: 23–25.
13-Mathumithra T, Koteeshwaran G, Jeevaraj G. Extra Skeletal Mesenchymal Chondrosarcoma – A Rare Case Report. International Journal of Science and Research.2013: 6.14 | Impact Factor (2015): 6.391 14- Brown HK, Schiavone K, Gouin F, Heymann MF, Heymann D. Biology of Bone Sarcomas and New Therapeutic Developments. Calcif Tissue Int. 2018 Feb;102(2):174-195.
15-Bret MW,Wendong H ,Benoit DC ,Alberto GA ,Bogdan C. Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors.Human PATHOLOGY J. March 2003Volume 34, Issue 3, Pages 263–269
16- Lee AF, Hayes MM, Lebrun D, Espinosa I, Nielsen GP, Rosenberg AE, Lee CH.FLI-1 distinguishes Ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma. Appl Immunohistochem Mol Morphol. 2011 May;19(3):233-8.
17- Genovefa P, Vasilios K, Seth M, Paul H, Alex L & Robin L. Novel therapeutic approaches in chondrosarcoma. Future Oncol. (2017) 13(7), 637–648
18- Nakashima Y, Unni KK, Shives TC, Swee RG, Dahlin DC. Mesenchymal chondrosarcoma of bone and soft tissue. A review of 111 cases. Cancer 1986;57:2444-53.
2-Priyanka S, Anil S, Sujata S, Sanjay S. Mesenchymal chondrosarcoma of mandible: A rare case report and review. J Oral Maxillofac Pathol. 2014 Sep; 18(Suppl 1): S167–S170.
3-Jaetli V, Gupta S.Mesenchymal chondrosarcoma of maxilla: a rare case report. Med Oral Patol Oral Cir Bucal. 2011 Jul 1;16(4):e493-6.
4-Ram H, Mohammad S, Husain N, Singh G.Huge mesenchymal chondrosarcoma of mandible . J Maxillofac Oral Surg.2011 Dec;10(4):340-3.
5-Kumar M, Suresh K, Patil M, Pramod R, Yusuf R, Bilahari N.Mesenchymal chondrosarcoma of posterior maxilla: report of a case with brief literature review. Ann Med Health Sci Res. 2014 Mar;4(Suppl 1):S49-52.
6- Tsuda Y, Ogura K, Hakozaki M, Kikuta K, Ae K, Tsuchiya H, Iwata S, Ueda T, Kawano H, Kawai A. Mesenchymal chondrosarcoma: A Japanese Musculoskeletal Oncology Group (JMOG) study on 57 patients. J Surg Oncol. 2017 May;115(6):760-767.
7- Rachel J. Shakked, David S. Geller,Richard Gorlick,Howard D. Dorfman.Mesenchymal Chondrosarcoma Clinicopathologic Study of 20 Cases. Arch Pathol Lab Med.2012 January ;Vol 136:61-75
8-Sumit M, Rajyalakshmi B, Divya U, Kameswara R.Mesenchymal chondrosarcoma of mandible. J Oral Maxillofac Pathol. 2016 Sep-Dec; 20(3): 545.
9- Angiero, Francesca; Vinci, Raffaele; Sidoni, Angelo; Stefani, Michele. Mesenchymal chondrosarcoma of the left coronoid process: Report of a unique case with clinical, histopathologic, and immunohistochemical findings, and a review of the literature. Quintessence International . Apr2007, Vol. 38 Issue 4, p349-355. 7p. 9 Color Photographs, 1 Black and White Photograph, 1 Chart.
10-Swanson PE , Lillemoe TJ , Manivel JC , Wick MR.Mesenchymal chondrosarcoma. An immunohistochemical study.Archives of Pathology & Laboratory Medicine [01 Sep 1990, 114(9):943-948]
11- Dobin SM, Donner LR, Speights VO Jr.Mesenchymal chondrosarcoma A cytogenetic, immunohistochemical and ultrastructural study. Cancer Genet Cytogenet. 1995 Aug;83(1):56-60.
12- Salehipour M, Hosseinzadeh M, Molaei Sisakhti A, Abdol Mohammadi Parvin V, Sadraei A, and Adib A.Renal Extra Skeletal Mesenchymal Chondrosarcoma: A Case Report. Urol Case Rep. 2017 May; 12: 23–25.
13-Mathumithra T, Koteeshwaran G, Jeevaraj G. Extra Skeletal Mesenchymal Chondrosarcoma – A Rare Case Report. International Journal of Science and Research.2013: 6.14 | Impact Factor (2015): 6.391 14- Brown HK, Schiavone K, Gouin F, Heymann MF, Heymann D. Biology of Bone Sarcomas and New Therapeutic Developments. Calcif Tissue Int. 2018 Feb;102(2):174-195.
15-Bret MW,Wendong H ,Benoit DC ,Alberto GA ,Bogdan C. Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors.Human PATHOLOGY J. March 2003Volume 34, Issue 3, Pages 263–269
16- Lee AF, Hayes MM, Lebrun D, Espinosa I, Nielsen GP, Rosenberg AE, Lee CH.FLI-1 distinguishes Ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma. Appl Immunohistochem Mol Morphol. 2011 May;19(3):233-8.
17- Genovefa P, Vasilios K, Seth M, Paul H, Alex L & Robin L. Novel therapeutic approaches in chondrosarcoma. Future Oncol. (2017) 13(7), 637–648
18- Nakashima Y, Unni KK, Shives TC, Swee RG, Dahlin DC. Mesenchymal chondrosarcoma of bone and soft tissue. A review of 111 cases. Cancer 1986;57:2444-53.
| Files | ||
| Issue | Vol 7, No 4 (Autumn 2020) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/jcr.v7i4.5560 | |
| Keywords | ||
| Mesenchymal chondrosarcoma; Mandible; Neoplasm. | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Derakhshan S, Rahrotaban S, Shirani S, Abbasi S. Mesenchymal chondrosarcoma of the mandible: A case report. J Craniomaxillofac Res. 2021;7(4):232-235.
