Temporomandibular disorders is associated with genetic factors: A review
-
Shamsoulmolouk Najafi
,
Narges Gholizadeh
,
Hassan Roudgari
,
Nafiseh Sheykhbahaei
,
Amir Mohammad Oloumi
Abstract
Background and Objectives: Pain is the most leading cause of visits to physicians and dentists. It is also a common symptom of diseases that can significantly undermine the quality of life and physical activities. This study aimed to review the existing literature for the causes of temporomandibular disorders (TMD) from the genetic point of view. Materials and Methods: Four international scientific databases including Google Scholar, Biomed Central, PubMed, and ProQuest plus two Iranian databases including Magiran and SID. Then all articles published between 1980 and 2019 were searched using the following keywords: facial pain, genetic factors and temporomandibular disorders (TMDs). A total of 900 articles were found that 36 were review articles. Results: Our review shows that genetic factors have an impact on the incidence and pathology of TMDs These factors include TSPAN9 polymorphism and the COMT gene. Conclusion: There is growing evidence indicating that genetic factors play a key role in the pathology of temporomandibular disorders, however, the underlying mechanism of pain is still largely unknown
1. Nixdorf D, Drangsholt M, Ettlin D, Gaul C, De Leeuw R, Svensson P, et al. Classifying orofacial pains: a new proposal of taxonomy based on ontology. Journal of oral rehabilitation 2012;39:161-9.
2.Matsuyama Y, Aida J, Watt R, Tsuboya T, Koyama S, Sato Y, et al. Dental Status and Compression of Life Expectancy with Disability. Journal of dental research 2017;96:1006-13.
3. Xue X-T, Kou X-X, Li C-S, Bi R-Y, Meng Z, Wang X-D, et al. Progesterone attenuates temporomandibular joint inflammation through inhibition of the NF-κB pathway in ovariectomized rats. Scientific reports 2017;7:15334.
4. Durham PL. Diverse physiological roles of calcitonin gene-related peptide in migraine pathology: modulation of neuronal-glial-immune cells to promote peripheral and central sensitization. Current pain and headache reports 2016;20:48.
5. Oakley M, Vieira A. The many faces of the genetics contribution to temporomandibular joint disorder. Orthodontics & craniofacial research 2008;11:125-35
6. Gary D. Slade, Roger B Fillingim, Anne E. Sanders, Eric Bair, Joel D Greenspan, Richard Ohrbach, Ron Dubner, Luda Diatchenko, Shad B. Smith, Charles Knott, and William Summary of Findings from the OPERA Prospective Cohort Study of Incidence of First-Onset Temporomandibular Disorders: Implications and Future Directions MaixnerJ Pain. 2013 Dec; 14(12 0),DOI:10.1016/j.jpain.2013.09.010
7.Oakley M, Vieira AR.The many faces of the genetics contribution to temporomandibular joint disorder. 2008;11:125–135
8.Slade GD, Smith SB, Zaykin DV, Tchivileva IE, Gibson DG, Yuryev A, et al. Facial pain with localized and widespread manifestations: separate pathways of vulnerability. Pain. 2013;154:2335–43.
9. Michelotti A, Liguori R, Toriello M, D'Anto` V, Vitale D, Castaldo G, et al. Catechol-O- methyltransferase (COMT) gene polymorphisms as a risk factor in temporomandibular disorders
patients from southern Italy. Clin J Pain. 2014;30:129–33.
10. Diatchenko L, Anderson AD, Slade GD, Fillingim RB, Shabalina SA, Higgins TJ, et al. Three major haplotypes of the beta2 adrenergic receptor define the psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:449–62.
[11]Aneiros-Guerrero A, Lendinez AM, Palomares AR, Perez- Nevot B, Aguado L, Mayor-Olea A, et al. Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to the temporomandibular disorder. BMC Med Genet. 2011;12:75–83.
[12] Ribeiro-Dasilva MC, Peres Line SR, Leme Godoy dos Santos MC, Arthur MT, Hou W, Fillingim RB, et al. Estrogen receptor-alpha polymorphisms and predisposition to TMJ disorder. J Pain. 2009; 10:527–33.
13..Huang B, Takahashi K, Sakata T, Kiso H, Sugal M, Fujimura K, et al. Increased risk of temporomandibular joint closed-lock: a case-control study of ANKH polymorphisms. PLoS One. 2011;6:e25503.
14. .Henry CH, Nikaein A, Wolford LM. Analysis of human leukocyte antigens in patients with internal derangement of the temporomandibular joint. J Oral Maxillofac Surg. 2002;60:778–83.
15.Planello AC, Campos MI, Meloto CB, Secolin R, Rizatti- Barbosa CM, Line SR, et al. Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration. Eur J Oral Sci. 2011;119:1–6.
16. Slade GD, Conrad MS, Diatchenko L, Rashid NU, Zhong S, Smith S, et al. Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness. Pain. 2011;152:2802–12.
17.Planello AC, Campos MI, Meloto CB, Secolin R, Rizatti‐Barbosa CM, Line SR, et al. Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration. European journal of oral sciences 2011;119:1-6
18.Dhruva Sanghani, Akiko Suzuki, Helena VonVille, James E. Hixson, and Junichi Iwata. Gene Mutations Associated with Temporomandibular Joint Disorders: A Systematic Review.OAlib. 2015 ; 2(6): . DOI:10.4236/oalib.1101583
19. Smith SB, Parisien M, Bair E, Belfer I, Chabot-Doré AJ, Gris P. Genome-wide association reveals the contribution of MRAS to painful temporomandibular disorder in males. Pain. 2019 Mar;160(3):579-59
20. Huang B, Takahashi K, Sakata T, Kiso H, Sugai M, Fujimura K, et al. Increased risk of temporomandibular joint closed lock: a case-control study of ANKH polymorphisms. PLoS One 2011;6:e25503.
21. Kim B-S, Kim Y-K, Yun P-Y, Lee E, Bae J. The effects of estrogen receptor α polymorphism on the prevalence of symptomatic temporomandibular disorders. Journal of Oral and Maxillofacial Surgery 2010;68:2975-9.
22.Melissa Stemig, Sandra L. Myers, Shanti Kaimal, Mohammad Saiful Islam. Estrogen receptor-alpha polymorphism in patients with and without degenerative disease of the temporomandibular joint. The Journal of Craniomandibular & Sleep Practice. 2015 (33)- 2
23. Helenius L, Hallikainen D, Helenius I, Meurman JH, Koskimies S, Tervahartiala P, et al. HLA‐DRB1* alleles and temporomandibular joint erosion in patients with various rheumatic diseases. Scandinavian journal of rheumatology 2004;33:24-9.
24. Bradshaw DH, Davis P, Lipschitz D, Nakamura Y, Chapman CR. Trends in funding for research on pain: a report on the National Institutes of Health grant awards over the years 2003 to 2007. The Journal of Pain 2008;9:1077-87. e8.
25. Greene CS. Diagnosis and treatment of temporomandibular disorders: the emergence of a new care guidelines statement. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2010;110:137-9.
26. De Souza Tesch R, Ladeira Bonato L, Quinelato V, Ladeira Casado P, Rezende Vieira A, Granjeiro JM, Góes C Evaluation of genetic risk related to catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients. Int J Oral Maxillofac Surg. 2020 Feb;49(2):237-243
27. Slade GD, Conrad MS, Diatchenko L, Rashid NU, Zhong S, Smith S, et al. Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness.Pain. 2011 Dec;152(12):2802-12
28.Brancher JA, Spada PP1, Meger MN, Fatturri AL, Dalledone M, de Paiva Bertoli FM, et al. The association of genetic polymorphisms in serotonin transporter and catechol-O-methyltransferase on temporomandibular disorders and anxiety in adolescents. J Oral Rehabil. 2019 Jul;46(7):597-604.
29.Li Y, Cai H, Fang W, Meng Q, Li J, Deng M, et al. Fibroblast growth factor 2 involved in the pathogenesis of synovial chondromatosis of the temporomandibular joint. Journal of Oral Pathology & Medicine 2014;43:388-94
30. Yamaguchi T, Nakaoka H, Yamamoto K, Fujikawa T, Kim YI, Yano K, et al. Genome‐wide association study of degenerative bony changes of the temporomandibular joint. Oral diseases 2014;20:409-15.
31. Mutlu N, Emin Erdal M, Herken H, Ozkaya M, Erdal N, Oz G, et al. Monoamine oxidase-A gene promoter polymorphism in temporomandibular joint pain and dysfunction. The Pain Clinic 2005;17:39-44.
32. Ojima K, Watanabe N, Narita N, Narita M. Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population. BioPsychoSocial medicine 2007;1:3.
33. Turner MK, Nurse AF, Tekcan A, Yerliyurt K, Geyko A, Yigit S. The IL‐1Ra gene variable number tandem repeat variant is associated with susceptibility to temporomandibular disorders in Turkish population. Journal of clinical laboratory analysis 2018;32:e22255.
34. Meloto CB, Serrano PO, Ribeiro-DaSilva MC, Rizzatti-Barbosa CM. Genomics and the new perspectives for temporomandibular disorders. Archives of oral biology 2011;56:1181-91.
35. Smith SB, Parisien M, Bair E, Belfer I, Chabot-Doré AJ, Gris P. Genome-wide association reveals the contribution of MRAS to painful temporomandibular disorder in males. Pain. 2019 Mar;160(3):579-59
36. de Freitas LV, Lopes AC, Piatto VB, Maniglia JV. Association of temporomandibular dysfunction with the 102T-C polymorphism in the serotonin receptor gene in Brazilian patients. Arch Med Sci. 2013 30;9(6):1013-834. Love S, Cookham HB. Trigeminal neuralgia: pathology and pathogenesis. Brain 2001;124:2347-60.
2.Matsuyama Y, Aida J, Watt R, Tsuboya T, Koyama S, Sato Y, et al. Dental Status and Compression of Life Expectancy with Disability. Journal of dental research 2017;96:1006-13.
3. Xue X-T, Kou X-X, Li C-S, Bi R-Y, Meng Z, Wang X-D, et al. Progesterone attenuates temporomandibular joint inflammation through inhibition of the NF-κB pathway in ovariectomized rats. Scientific reports 2017;7:15334.
4. Durham PL. Diverse physiological roles of calcitonin gene-related peptide in migraine pathology: modulation of neuronal-glial-immune cells to promote peripheral and central sensitization. Current pain and headache reports 2016;20:48.
5. Oakley M, Vieira A. The many faces of the genetics contribution to temporomandibular joint disorder. Orthodontics & craniofacial research 2008;11:125-35
6. Gary D. Slade, Roger B Fillingim, Anne E. Sanders, Eric Bair, Joel D Greenspan, Richard Ohrbach, Ron Dubner, Luda Diatchenko, Shad B. Smith, Charles Knott, and William Summary of Findings from the OPERA Prospective Cohort Study of Incidence of First-Onset Temporomandibular Disorders: Implications and Future Directions MaixnerJ Pain. 2013 Dec; 14(12 0),DOI:10.1016/j.jpain.2013.09.010
7.Oakley M, Vieira AR.The many faces of the genetics contribution to temporomandibular joint disorder. 2008;11:125–135
8.Slade GD, Smith SB, Zaykin DV, Tchivileva IE, Gibson DG, Yuryev A, et al. Facial pain with localized and widespread manifestations: separate pathways of vulnerability. Pain. 2013;154:2335–43.
9. Michelotti A, Liguori R, Toriello M, D'Anto` V, Vitale D, Castaldo G, et al. Catechol-O- methyltransferase (COMT) gene polymorphisms as a risk factor in temporomandibular disorders
patients from southern Italy. Clin J Pain. 2014;30:129–33.
10. Diatchenko L, Anderson AD, Slade GD, Fillingim RB, Shabalina SA, Higgins TJ, et al. Three major haplotypes of the beta2 adrenergic receptor define the psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:449–62.
[11]Aneiros-Guerrero A, Lendinez AM, Palomares AR, Perez- Nevot B, Aguado L, Mayor-Olea A, et al. Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to the temporomandibular disorder. BMC Med Genet. 2011;12:75–83.
[12] Ribeiro-Dasilva MC, Peres Line SR, Leme Godoy dos Santos MC, Arthur MT, Hou W, Fillingim RB, et al. Estrogen receptor-alpha polymorphisms and predisposition to TMJ disorder. J Pain. 2009; 10:527–33.
13..Huang B, Takahashi K, Sakata T, Kiso H, Sugal M, Fujimura K, et al. Increased risk of temporomandibular joint closed-lock: a case-control study of ANKH polymorphisms. PLoS One. 2011;6:e25503.
14. .Henry CH, Nikaein A, Wolford LM. Analysis of human leukocyte antigens in patients with internal derangement of the temporomandibular joint. J Oral Maxillofac Surg. 2002;60:778–83.
15.Planello AC, Campos MI, Meloto CB, Secolin R, Rizatti- Barbosa CM, Line SR, et al. Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration. Eur J Oral Sci. 2011;119:1–6.
16. Slade GD, Conrad MS, Diatchenko L, Rashid NU, Zhong S, Smith S, et al. Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness. Pain. 2011;152:2802–12.
17.Planello AC, Campos MI, Meloto CB, Secolin R, Rizatti‐Barbosa CM, Line SR, et al. Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration. European journal of oral sciences 2011;119:1-6
18.Dhruva Sanghani, Akiko Suzuki, Helena VonVille, James E. Hixson, and Junichi Iwata. Gene Mutations Associated with Temporomandibular Joint Disorders: A Systematic Review.OAlib. 2015 ; 2(6): . DOI:10.4236/oalib.1101583
19. Smith SB, Parisien M, Bair E, Belfer I, Chabot-Doré AJ, Gris P. Genome-wide association reveals the contribution of MRAS to painful temporomandibular disorder in males. Pain. 2019 Mar;160(3):579-59
20. Huang B, Takahashi K, Sakata T, Kiso H, Sugai M, Fujimura K, et al. Increased risk of temporomandibular joint closed lock: a case-control study of ANKH polymorphisms. PLoS One 2011;6:e25503.
21. Kim B-S, Kim Y-K, Yun P-Y, Lee E, Bae J. The effects of estrogen receptor α polymorphism on the prevalence of symptomatic temporomandibular disorders. Journal of Oral and Maxillofacial Surgery 2010;68:2975-9.
22.Melissa Stemig, Sandra L. Myers, Shanti Kaimal, Mohammad Saiful Islam. Estrogen receptor-alpha polymorphism in patients with and without degenerative disease of the temporomandibular joint. The Journal of Craniomandibular & Sleep Practice. 2015 (33)- 2
23. Helenius L, Hallikainen D, Helenius I, Meurman JH, Koskimies S, Tervahartiala P, et al. HLA‐DRB1* alleles and temporomandibular joint erosion in patients with various rheumatic diseases. Scandinavian journal of rheumatology 2004;33:24-9.
24. Bradshaw DH, Davis P, Lipschitz D, Nakamura Y, Chapman CR. Trends in funding for research on pain: a report on the National Institutes of Health grant awards over the years 2003 to 2007. The Journal of Pain 2008;9:1077-87. e8.
25. Greene CS. Diagnosis and treatment of temporomandibular disorders: the emergence of a new care guidelines statement. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2010;110:137-9.
26. De Souza Tesch R, Ladeira Bonato L, Quinelato V, Ladeira Casado P, Rezende Vieira A, Granjeiro JM, Góes C Evaluation of genetic risk related to catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients. Int J Oral Maxillofac Surg. 2020 Feb;49(2):237-243
27. Slade GD, Conrad MS, Diatchenko L, Rashid NU, Zhong S, Smith S, et al. Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness.Pain. 2011 Dec;152(12):2802-12
28.Brancher JA, Spada PP1, Meger MN, Fatturri AL, Dalledone M, de Paiva Bertoli FM, et al. The association of genetic polymorphisms in serotonin transporter and catechol-O-methyltransferase on temporomandibular disorders and anxiety in adolescents. J Oral Rehabil. 2019 Jul;46(7):597-604.
29.Li Y, Cai H, Fang W, Meng Q, Li J, Deng M, et al. Fibroblast growth factor 2 involved in the pathogenesis of synovial chondromatosis of the temporomandibular joint. Journal of Oral Pathology & Medicine 2014;43:388-94
30. Yamaguchi T, Nakaoka H, Yamamoto K, Fujikawa T, Kim YI, Yano K, et al. Genome‐wide association study of degenerative bony changes of the temporomandibular joint. Oral diseases 2014;20:409-15.
31. Mutlu N, Emin Erdal M, Herken H, Ozkaya M, Erdal N, Oz G, et al. Monoamine oxidase-A gene promoter polymorphism in temporomandibular joint pain and dysfunction. The Pain Clinic 2005;17:39-44.
32. Ojima K, Watanabe N, Narita N, Narita M. Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population. BioPsychoSocial medicine 2007;1:3.
33. Turner MK, Nurse AF, Tekcan A, Yerliyurt K, Geyko A, Yigit S. The IL‐1Ra gene variable number tandem repeat variant is associated with susceptibility to temporomandibular disorders in Turkish population. Journal of clinical laboratory analysis 2018;32:e22255.
34. Meloto CB, Serrano PO, Ribeiro-DaSilva MC, Rizzatti-Barbosa CM. Genomics and the new perspectives for temporomandibular disorders. Archives of oral biology 2011;56:1181-91.
35. Smith SB, Parisien M, Bair E, Belfer I, Chabot-Doré AJ, Gris P. Genome-wide association reveals the contribution of MRAS to painful temporomandibular disorder in males. Pain. 2019 Mar;160(3):579-59
36. de Freitas LV, Lopes AC, Piatto VB, Maniglia JV. Association of temporomandibular dysfunction with the 102T-C polymorphism in the serotonin receptor gene in Brazilian patients. Arch Med Sci. 2013 30;9(6):1013-834. Love S, Cookham HB. Trigeminal neuralgia: pathology and pathogenesis. Brain 2001;124:2347-60.
| Files | ||
| Issue | Vol 9, No 2 (Spring 2022) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/jcr.v9i2.11737 | |
| Keywords | ||
| Facial pain Genetic factors Temporomandibular joint disorder (TMD). | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Najafi S, Gholizadeh N, Roudgari H, Sheykhbahaei N, Oloumi AM. Temporomandibular disorders is associated with genetic factors: A review. J Craniomaxillofac Res. 2022;9(2):69-80.
