The Evaluation the relationship between polymorphism of galactose mutarotase gene by creating jaw sound in patients with temporomandibular disorder (TMD)
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Abstract
Objective: One of the concerns of dentists is the referral of patients with temporomandibular problems. Temporomandibular joint disorders (TMD) is a complex multifactorial clinical problem that involves masticatory muscles, temporomandibular joint and related structures. This complication is one of the three common chronic pains after headache and low back pain, which can manifest as pain in the temporomandibular region and limitation in joint movements, or even as clicking, crepitus, and popping sounds during temporomandibular joint movements. For the first time, the american association for oral pain (AAOP) proposed the role of genetic factors in the development of TMD. It is thought that a complex disorder such as TMD is multidimensional and can be subjected to environmental conditions as well as multiple gene polymorphisms. Identification of single nucleotide polymorphisms in the human genome can play an important role in clinical setting for diagnosis, prognosis and therapeutic interventions in various diseases including TMD. The aim of this study was to evaluate the relationship between polymorphism of galactose mutarotase gene by creating jaw sound in patients with temporomandibular disorder in a population with high similarity to the whole Iranian population and using the results in prevention and targeted treatment of affected patients. Study Design: 101 patients with TMD using DC/TMD criteria among those referred to Tehran University School of Dentistry and 103 healthy subjects for TMD that have age and gender matched were selected to control groupfrom those referring to the Oral and Maxillofacial Diseases and Oral and Maxillofacial Pain departments. Blood samples were taken in 5cc and DNA extracted from the blood of both groups by applying the technique PCRARMS in terms of polymorphism rs4776783 in Galm gene were Compared. Results: 101 patients with TMD along with 103 healthy individuals without a history of TMD were evaluated to investigate rs4776783 polymorphism in GALM gene. The average age of the patients was 35.92, and 21 were men and 80 were women. According to the questionnaire, 61 people felt the sound in their jaw while moving. On the other hand, according to the TMD/DC criterion, the number of people who have crepitus in the right and left jaws is equal. The average age of the patients was 35.92, and 21 were men and 80 were women. According to the questionnaire, 61 people felt the sound in their jaw while moving. On the other hand, according to the TMD/DC criterion, the number of people who have crepitus in the right and left jaws is equal. The low prevalence of crepitation with p=0.734 has a significant relationship with the genotype of people. Conclusion: This study showed that there is a significant relationship between the rs4776783 polymorphism in Galm gene and the occurrence of temporomandibular disorder (TMD), jaw sound and pain in many masticatory muscles such as lateral pterygoid and temporal. Therefore, it can be concluded that TMD has a genetic basis.
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2 - Manfredini D, Guarda-Nardini L, Winocur E, Piccotti F, Ahlberg J, Lobbezoo F. Research diagnostic criteria for temporomandibular disorders: a systematic review of axis I epidemiologic findings. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2011 Oct 1;112(4):453-62.
3 - Murphy MK, MacBarb RF, Wong ME, Athanasiou KA. Temporomandibular joint disorders: a review of etiology, clinical management, and tissue engineering strategies. The International journal of oral & maxillofacial implants. 2013 Nov;28(6):e393.
4 - Basat SO, Surmeli M, Demirel O, Ceran F, Saydam FA, Basaran K. Assessment of the relationship between clinicophysiologic and magnetic resonance imaging findings of the temporomandibular disorder patients. Journal of Craniofacial Surgery. 2016 Nov 1;27(8):1946-50.
5 - Hirata FH, Guimarães AS, Oliveira JX, Moreira CR, Ferreira ET, Cavalcanti MG. Evaluation of TMJ articular eminence morphology and disc patterns in patients with disc displacement in MRI. Brazilian oral research. 2007;21:265-71.
6 - Chalkoo AH, Bhat ZA, Maqbool A. MRI characteristics of disc displacement of temporomandibular disorders and its correlation with clinical findings in symptomatic and asymptomatic. population. 2017;1(2):4-9.
7 - De Leeuw R, Klasser GD, editors. Orofacial pain: guidelines for assessment, diagnosis, and management. Hanover Park, IL: Quintessence Publishing Company, Incorporated; 2018.
8 - Hietaharju M, Kivimäki I, Heikkilä H, Näpänkangas R, Teerijoki‐Oksa T, Tanner J, Kemppainen P, Tolvanen M, Suvinen T, Sipilä K. Comparison of Axis II psychosocial assessment methods of RDC/TMD and DC/TMD as part of DC/TMD‐FIN phase II validation studies in tertiary care Finnish TMD pain patients. Journal of oral rehabilitation. 2021 Dec;48(12):1295-306.
9 - Wu J, Huang Z, Chen Y, Chen Y, Pan Z, Gu Y. Temporomandibular disorders among medical students in China: prevalence, biological and psychological risk factors. BMC oral health. 2021 Dec;21(1):1-8.
10 - Rantala M. Temporomandibular disorders and related psychosocial factors in non-patients: A survey and a clinical follow-up study based on the RDC/TMD.
11 - Meloto CB, Serrano PO, Ribeiro-DaSilva MC, Rizzatti-Barbosa CM. Genomics and the new perspectives for temporomandibular disorders. Archives of Oral Biology. 2011 Nov 1;56(11):1181-91.
12 - Michelotti A, Liguori R, Toriello M, D’Antò V, Vitale D, Castaldo G, Sacchetti L. Catechol-O-methyltransferase (COMT) gene polymorphisms as risk factor in temporomandibular disorders patients from Southern Italy. The Clinical journal of pain. 2014 Feb 1;30(2):129-33.
13 - Wright EF, North SL. Management and treatment of temporomandibular disorders: a clinical perspective. Journal of Manual & Manipulative Therapy. 2009 Dec 1;17(4):247-54.
14 - Look JO, Schiffman EL, Truelove EL, Ahmad M. Reliability and validity of Axis I of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) with proposed revisions. Journal of oral rehabilitation. 2010 Oct;37(10):744-59.
15 - Bashizade H, Goodarzpour D, Mofidi N. Correlation between eminence steepness and condyle disk movements in temporomandibular joints affected by internal derangements using magnetic resonance imaging. J Dent Med-Tehran Univ Med Sci. 2013 Jan 1;25:251-9.
16- Thoden JB, Timson DJ, Reece RJ, Holden HM. Molecular structure of human galactose mutarotase. Journal of Biological Chemistry. 2004 May 1;279(22):23431-7.
17 - de Souza Tesch R, Bonato LL, Quinelato V, Casado PL, Vieira AR, Granjeiro JM, Góes C. Evaluation of genetic risk related to catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients. International journal of oral and maxillofacial surgery. 2020 Feb 1;49(2):237-43.
18 - Brancher JA, Spada PP, Meger MN, Fatturri AL, Dalledone M, de Paiva Bertoli FM, Deeley K, Scariot R, Vieira AR, Küchler EC, de Souza JF. The association of genetic polymorphisms in serotonin transporter and catechol‐O‐methyltransferase on temporomandibular disorders and anxiety in adolescents. Journal of Oral Rehabilitation. 2019 Jul;46(7):597-604.
19 Melis M, Di Giosia M. The role of genetic factors in the etiology of temporomandibular disorders: a review. CRANIO®. 2016;34(1):51-67.
20 - Aneiros-Guerrero A, Lendinez AM, Palomares AR, Perez-Nevot B, Aguado L, Mayor-Olea A, Ruiz-Galdon M, Reyes-Engel A. Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder. BMC medical genetics. 2011 Dec;12(1):1-9.
21 -Catanzariti, J.-F., T. Debuse, and B. Duquesnoy, Chronic neck pain and masticatory dysfunction. Joint Bone Spine, 2005. 72(6): p. 515-519.
22- Bagis B, Ayaz EA, Turgut S, Durkan R, Özcan M. Gender difference in prevalence of signs and symptoms of temporomandibular joint disorders: a retrospective study on 243 consecutive patients. International journal of medical sciences. 2012;9(7):539.
2 - Manfredini D, Guarda-Nardini L, Winocur E, Piccotti F, Ahlberg J, Lobbezoo F. Research diagnostic criteria for temporomandibular disorders: a systematic review of axis I epidemiologic findings. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2011 Oct 1;112(4):453-62.
3 - Murphy MK, MacBarb RF, Wong ME, Athanasiou KA. Temporomandibular joint disorders: a review of etiology, clinical management, and tissue engineering strategies. The International journal of oral & maxillofacial implants. 2013 Nov;28(6):e393.
4 - Basat SO, Surmeli M, Demirel O, Ceran F, Saydam FA, Basaran K. Assessment of the relationship between clinicophysiologic and magnetic resonance imaging findings of the temporomandibular disorder patients. Journal of Craniofacial Surgery. 2016 Nov 1;27(8):1946-50.
5 - Hirata FH, Guimarães AS, Oliveira JX, Moreira CR, Ferreira ET, Cavalcanti MG. Evaluation of TMJ articular eminence morphology and disc patterns in patients with disc displacement in MRI. Brazilian oral research. 2007;21:265-71.
6 - Chalkoo AH, Bhat ZA, Maqbool A. MRI characteristics of disc displacement of temporomandibular disorders and its correlation with clinical findings in symptomatic and asymptomatic. population. 2017;1(2):4-9.
7 - De Leeuw R, Klasser GD, editors. Orofacial pain: guidelines for assessment, diagnosis, and management. Hanover Park, IL: Quintessence Publishing Company, Incorporated; 2018.
8 - Hietaharju M, Kivimäki I, Heikkilä H, Näpänkangas R, Teerijoki‐Oksa T, Tanner J, Kemppainen P, Tolvanen M, Suvinen T, Sipilä K. Comparison of Axis II psychosocial assessment methods of RDC/TMD and DC/TMD as part of DC/TMD‐FIN phase II validation studies in tertiary care Finnish TMD pain patients. Journal of oral rehabilitation. 2021 Dec;48(12):1295-306.
9 - Wu J, Huang Z, Chen Y, Chen Y, Pan Z, Gu Y. Temporomandibular disorders among medical students in China: prevalence, biological and psychological risk factors. BMC oral health. 2021 Dec;21(1):1-8.
10 - Rantala M. Temporomandibular disorders and related psychosocial factors in non-patients: A survey and a clinical follow-up study based on the RDC/TMD.
11 - Meloto CB, Serrano PO, Ribeiro-DaSilva MC, Rizzatti-Barbosa CM. Genomics and the new perspectives for temporomandibular disorders. Archives of Oral Biology. 2011 Nov 1;56(11):1181-91.
12 - Michelotti A, Liguori R, Toriello M, D’Antò V, Vitale D, Castaldo G, Sacchetti L. Catechol-O-methyltransferase (COMT) gene polymorphisms as risk factor in temporomandibular disorders patients from Southern Italy. The Clinical journal of pain. 2014 Feb 1;30(2):129-33.
13 - Wright EF, North SL. Management and treatment of temporomandibular disorders: a clinical perspective. Journal of Manual & Manipulative Therapy. 2009 Dec 1;17(4):247-54.
14 - Look JO, Schiffman EL, Truelove EL, Ahmad M. Reliability and validity of Axis I of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) with proposed revisions. Journal of oral rehabilitation. 2010 Oct;37(10):744-59.
15 - Bashizade H, Goodarzpour D, Mofidi N. Correlation between eminence steepness and condyle disk movements in temporomandibular joints affected by internal derangements using magnetic resonance imaging. J Dent Med-Tehran Univ Med Sci. 2013 Jan 1;25:251-9.
16- Thoden JB, Timson DJ, Reece RJ, Holden HM. Molecular structure of human galactose mutarotase. Journal of Biological Chemistry. 2004 May 1;279(22):23431-7.
17 - de Souza Tesch R, Bonato LL, Quinelato V, Casado PL, Vieira AR, Granjeiro JM, Góes C. Evaluation of genetic risk related to catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients. International journal of oral and maxillofacial surgery. 2020 Feb 1;49(2):237-43.
18 - Brancher JA, Spada PP, Meger MN, Fatturri AL, Dalledone M, de Paiva Bertoli FM, Deeley K, Scariot R, Vieira AR, Küchler EC, de Souza JF. The association of genetic polymorphisms in serotonin transporter and catechol‐O‐methyltransferase on temporomandibular disorders and anxiety in adolescents. Journal of Oral Rehabilitation. 2019 Jul;46(7):597-604.
19 Melis M, Di Giosia M. The role of genetic factors in the etiology of temporomandibular disorders: a review. CRANIO®. 2016;34(1):51-67.
20 - Aneiros-Guerrero A, Lendinez AM, Palomares AR, Perez-Nevot B, Aguado L, Mayor-Olea A, Ruiz-Galdon M, Reyes-Engel A. Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder. BMC medical genetics. 2011 Dec;12(1):1-9.
21 -Catanzariti, J.-F., T. Debuse, and B. Duquesnoy, Chronic neck pain and masticatory dysfunction. Joint Bone Spine, 2005. 72(6): p. 515-519.
22- Bagis B, Ayaz EA, Turgut S, Durkan R, Özcan M. Gender difference in prevalence of signs and symptoms of temporomandibular joint disorders: a retrospective study on 243 consecutive patients. International journal of medical sciences. 2012;9(7):539.
| Files | ||
| Issue | Vol 9, No 1 (Winter 2022) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/jcr.v9i1.11081 | |
| Keywords | ||
| Galactose mutarotase GALM Temporomandibular disorder Polymorphism | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Najafi S, Roudgari H, Sheykhbahaei N, Tajik Z, Asadighalhari S. The Evaluation the relationship between polymorphism of galactose mutarotase gene by creating jaw sound in patients with temporomandibular disorder (TMD). J Craniomaxillofac Res. 2022;9(1):31-39.
