Central giant cell granuloma mimicking a malignant lesion of mandible: A case report
-
Fereshteh Najar Karimi
,
Mina Jazayeri
,
Fatemeh Abbasi
,
Deniz Safabakhsh
,
Fatemeh Ahmadi Motamayel
Abstract
Central giant cell granuloma (CGCG) is a relatively uncommon benign osseous lesion with sometimes aggressive nature. The nature of this lesion is unknown and although the exact cause is unclear, the three theories about possibility of its nature are: developmental anomaly, reactive lesion or benign neoplasm. Histologically by presence of multinucleated giant cells within a stroma of spindle-shaped mesenchymal and fibro vascular connective tissue along with containing of hemorrhagic areas is characterized. This case report presents the diagnosis and management of a CGCG in a 50 years-old man with biopsy and surgical treatments. The lesion involve the left side of mandibular. Diagnosis plan was designed based on the combination of pathology and imaging. Finally after en bloc resection of involved regions of mandible, a titanium plate prosthesis was used for the jaw reconstruction. Since some of CGCG lesions can be highly invasive and inclinically and radiographic features can mimic as malignancy lesions.
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2. Choe M, Smith V, Okcu MF, Wulff J, Gruner S, Huisman TAGM, et al. Treatment of central giant cell granuloma in children with denosumab. Pediatric Blood & Cancer. 2021;68(3):e28778.
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6. Stavropoulos F, Katz J. Central giant cell granulomas: a systematic review of the radiographic characteristics with the addition of 20 new cases. Dento maxillo facial radiology. 2002;31(4):213-7.
7. Deshpande A, Munde A, Mishra S, Kawsankar K, Sawade R, Nayak P. Aggressive giant cell granuloma of mandible: A case report. IP International Journal of Maxillofacial Imaging. 2021;6(4):118-21.
8. Ustad F. Aggressive Variant of Central Giant Cell Granuloma. 2018.
9. Wang Y, Le A, El Demellawy D, Shago M, Odell M, Johnson-Obaseki S. An aggressive central giant cell granuloma in a pediatric patient: case report and review of literature. Journal of Otolaryngology - Head & Neck Surgery. 2019;48(1):32.
10. Adesina AO, Ladeji MA, Opaleye TO, Moradeke A, Ojikutu R, Salami AY, et al. Case reports: An aggressive central giant cell granuloma of the jaws in two pediatric patients. Journal of Pediatric Surgery Case Reports. 2021;73:102019.
11. Kruse-Lösler B, Diallo R, Gaertner C, Mischke KL, Joos U, Kleinheinz J. Central giant cell granuloma of the jaws: a clinical, radiologic, and histopathologic study of 26 cases. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2006;101(3):346-54.
12. Ustündağ E, Iseri M, Keskin G, Müezzinoğlu B. Central giant cell granuloma. International journal of pediatric otorhinolaryngology. 2002;65(2):143-6.
13. Jadu FM, Pharoah MJ, Lee L, Baker GI, Allidina A. Central giant cell granuloma of the mandibular condyle: a case report and review of the literature. Dento maxillo facial radiology. 2011;40(1):60-4.
14. Cidrac L, Kadri M, Pecorari R, Nguyen T, Radoï L. Diagnostic difficulty of an aggressive and recurrent giant cell granuloma: a short case report. Journal of Oral Medicine and Oral Surgery. 2021;27:12.
15. Kumar G, Manjunatha B. Metastatic tumors to the jaws and oral cavity. J Oral Maxillofac Pathol. 2013;17(1):71-5.
16. Lee RJ, Arshi A, Schwartz HC, Christensen RE. Characteristics and prognostic factors of osteosarcoma of the jaws: a retrospective cohort study. JAMA otolaryngology-- head & neck surgery. 2015;141(5):470-7.
17. Shohat I, Shoshani Y, Taicher S. [Medical treatment of central giant cell granuloma of the jaws]. Refu'at ha-peh veha-shinayim (1993). 2002;19(4):37-44, 70.
2. Choe M, Smith V, Okcu MF, Wulff J, Gruner S, Huisman TAGM, et al. Treatment of central giant cell granuloma in children with denosumab. Pediatric Blood & Cancer. 2021;68(3):e28778.
3. Stewart JCB. Chapter 12 - Benign Nonodontogenic Tumors. In: Regezi JA, Sciubba JJ, Jordan RCK, editors. Oral Pathology (Sixth Edition). St. Louis: W.B. Saunders; 2012. p. 293-313.
4. Elmezwghi AM, Alarabi NM, Elsagali AH, Zariba SSM, BenGharbia NE, Musa NH. An aggressive central giant cell granuloma of maxilla: Diagnostic dilemma, Precise differential diagnosis and successful traditional surgical approach: A case report. Egyptian Dental Journal. 2020;66(Issue 4 - October (Oral Surgery)):2075-83.
5. Jeyaraj P. Management of Central Giant Cell Granulomas of the Jaws: An Unusual Case Report with Critical Appraisal of Existing Literature. Ann Maxillofac Surg. 2019;9(1):37-47.
6. Stavropoulos F, Katz J. Central giant cell granulomas: a systematic review of the radiographic characteristics with the addition of 20 new cases. Dento maxillo facial radiology. 2002;31(4):213-7.
7. Deshpande A, Munde A, Mishra S, Kawsankar K, Sawade R, Nayak P. Aggressive giant cell granuloma of mandible: A case report. IP International Journal of Maxillofacial Imaging. 2021;6(4):118-21.
8. Ustad F. Aggressive Variant of Central Giant Cell Granuloma. 2018.
9. Wang Y, Le A, El Demellawy D, Shago M, Odell M, Johnson-Obaseki S. An aggressive central giant cell granuloma in a pediatric patient: case report and review of literature. Journal of Otolaryngology - Head & Neck Surgery. 2019;48(1):32.
10. Adesina AO, Ladeji MA, Opaleye TO, Moradeke A, Ojikutu R, Salami AY, et al. Case reports: An aggressive central giant cell granuloma of the jaws in two pediatric patients. Journal of Pediatric Surgery Case Reports. 2021;73:102019.
11. Kruse-Lösler B, Diallo R, Gaertner C, Mischke KL, Joos U, Kleinheinz J. Central giant cell granuloma of the jaws: a clinical, radiologic, and histopathologic study of 26 cases. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2006;101(3):346-54.
12. Ustündağ E, Iseri M, Keskin G, Müezzinoğlu B. Central giant cell granuloma. International journal of pediatric otorhinolaryngology. 2002;65(2):143-6.
13. Jadu FM, Pharoah MJ, Lee L, Baker GI, Allidina A. Central giant cell granuloma of the mandibular condyle: a case report and review of the literature. Dento maxillo facial radiology. 2011;40(1):60-4.
14. Cidrac L, Kadri M, Pecorari R, Nguyen T, Radoï L. Diagnostic difficulty of an aggressive and recurrent giant cell granuloma: a short case report. Journal of Oral Medicine and Oral Surgery. 2021;27:12.
15. Kumar G, Manjunatha B. Metastatic tumors to the jaws and oral cavity. J Oral Maxillofac Pathol. 2013;17(1):71-5.
16. Lee RJ, Arshi A, Schwartz HC, Christensen RE. Characteristics and prognostic factors of osteosarcoma of the jaws: a retrospective cohort study. JAMA otolaryngology-- head & neck surgery. 2015;141(5):470-7.
17. Shohat I, Shoshani Y, Taicher S. [Medical treatment of central giant cell granuloma of the jaws]. Refu'at ha-peh veha-shinayim (1993). 2002;19(4):37-44, 70.
| Files | ||
| Issue | Vol 9, No 2 (Spring 2022) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/jcr.v9i2.11743 | |
| Keywords | ||
| Central giant cell granuloma Malignant lesion Case report | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Najar Karimi F, Jazayeri M, Abbasi F, Safabakhsh D, Ahmadi Motamayel F. Central giant cell granuloma mimicking a malignant lesion of mandible: A case report. J Craniomaxillofac Res. 2022;9(2):106-109.
