An evaluation on diagnosis and management patterns of patients with oral squamous cell carcinoma referred to the Cancer Institute of Tehran University of Medical Sciences during 2010-2021
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Abstract
Background: Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity with multiple complications associated with the disease and its treatments and a high mortality rate. In the present study we aimed to assess the diagnosis and management of these patients referring to Imam Khomeini Hospital during 2010-2021, their survival rate and possible factors affecting mortality of the patients. Materials and Methods: In this retrospective descriptive-analytic study, patients diagnosed with oral SCC referring to Imam Khomeini Hospital during 2010-2021 were included. Required data were gathered from the patients’ records and analyzed by SPSS software last version and Microsoft Excel using the Log-rank test and Kaplan-Meier survival curves. Results: In the specified period 146 patients with oral SCC were admitted to Imam Khomeini Hospital with a mean age of 63.4±18.1 years and a slightly higher prevalence of men. Most patients had an educational level of lower than diploma (60.2%), were living in urban areas (78.6%), were treated by a general dentist or a general practitioner (86.8%), primarily underwent surgery (78.8%) and their treatment followed the standard management for these patients (86.3%). 69.2% of the patients stayed alive until the studied period and the buccal mucosa was the most commonly involved location (51.7%). The mean survival of the patients was calculated to be 3384.3 days which was found to be affected by the educational level and compatibility of their treatment with standard guidelines. Conclusion: The mean survival of the subjects was 9.3 years. The survival of the patients decreased from 100% to 0.4% after the 12 years period which is promising. These results indicate the effectiveness of following standard treatment protocols and early diagnosis of the patients in early stages of the disease. Keywords: Oral squamous cell carcinoma; Survival; Kaplan-meier.
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7. Horowitz AM, Alfano MC. Performing a death-defying act. The Journal of the American Dental Association. 2001;132:5S-6S.
8. Silverman Jr S, Kerr AR, Epstein JB. Oral and pharyngeal cancer control and early detection. Journal of Cancer Education. 2010;25(3):279-81.
9. Sargeran K, Murtomaa H, Safavi SMR, Vehkalahti M, Teronen O. Malignant oral tumors in Iran: ten-year analysis on patient and tumor characteristics of 1042 patients in Tehran. Journal of Craniofacial Surgery. 2006;17(6):1230-3.
10. Normak W, Reichart P, Philipsen H. Differential diagnosis of oral and maxillofacial lesions. Thieme Medical Publishers; 2000.
11. Lynch MA, Brightman VJ, Greenberg MS. Burket's oral medicine: diagnosis and treatment: Lippincott; 1977.
12. Leao J, Goes P, Sobrinho C, Porter S. Knowledge and clinical expertise regarding oral cancer among Brazilian dentists. International journal of oral and maxillofacial surgery. 2005;34(4):436-9.
13. Horowitz AM, Siriphant P, Sheikh A, CHILD WL. Perspectives of Maryland dentists on oral cancer. The Journal of the American Dental Association. 2001;132(1):65-72.
14. Regezi JA, Sciubba JJ, Jordan RC. Oral pathology: clinical pathologic correlations: Elsevier Health Sciences; 2016.
15. Llewellyn CD, Linklater K, Bell J, Johnson NW, Warnakulasuriya S. An analysis of risk factors for oral cancer in young people: a case-control study. Oral oncology. 2004;40(3):304-13.
16. Chen J, Katz R, Krutch Koff D. Intral oral SCC epidmiologic pattern in connecticiut. Cancer. 1991;66:1288-98.
17. Torossian J-M, Beziat J-L, Philip T, Bejui FT. Squamous cell carcinoma of the tongue in a 13-year- old boy. Journal of oral and maxillofacial surgery. 2000;58(12):1407-10.
18. Chen Y, Huang H, Lin L, Lin C. Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan. Oral oncology. 1999;35(2):173-9.
19. Jansisyanont P, Pazoki A, Ord RA. Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi's anemia. Journal of oral and maxillofacial surgery. 2000;58(12):1454-7.
20. Kuriakose M, Sankaranarayanan M, Nair M, Cherian T, Sugar A, Scully C, et al. Comparison of oral squamous cell carcinoma in younger and older patients in India. European Journal of Cancer Part B: Oral Oncology. 1992;28(2):113-20.
21. Harrison LB, Sessions RB, Hong WK. Head and neck cancer: a multidisciplinary approach: Lippincott Williams & Wilkins; 2009.
22. Cunnane MF. Head and Neck Pathology With Clinical Correlations. Human Pathology. 2001;32(10):1140.
23. Shah JP, Patel SG. Cancer of the head and neck: PMPH-USA; 2001.
24. Brennan JA, Boyle JO, Koch WM, Goodman SN, Hruban RH, Eby YJ, et al. Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck. New England Journal of Medicine. 1995;332(11):712-7.
25. Little JW, Falace D, Miller C, Rhodus NL. Dental Management of the Medically Compromised Patient-Pageburst on VitalSource: Elsevier Health Sciences; 2007.
26. Melo MD, Obeid G. Osteonecrosis of the jaws in patients with a history of receiving bisphosphonate therapy: strategies for prevention and early recognition. The Journal of the American Dental Association. 2005;136(12):1675-81.
27. Ord RA, Blanchaert Jr RH. Oral cancer: The dentist’s role in diagnosis, management,
rehabilitation, and prevention: Chicago; 2000.
2. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International journal of cancer. 2010;127(12):2893-917.
3. Petersen PE. Strengthening the prevention of oral cancer: the WHO perspective. Community dentistry and oral epidemiology. 2005;33(6):397-9.
4. Neville BW, Day TA. Oral cancer and precancerous lesions. CA: a cancer journal for clinicians. 2002;52(4):195-215.
5. Adelstein DJ, Rodriguez CP. Human papillomavirus: changing paradigms in oropharyngeal cancer. Current oncology reports. 2010;12(2):115-20.
6. Pitiphat W, Diehl S, Laskaris G, Cartsos V, Douglass C, Zavras A. Factors associated with delay in the diagnosis of oral cancer. Journal of dental research. 2002;81(3):192-7.
7. Horowitz AM, Alfano MC. Performing a death-defying act. The Journal of the American Dental Association. 2001;132:5S-6S.
8. Silverman Jr S, Kerr AR, Epstein JB. Oral and pharyngeal cancer control and early detection. Journal of Cancer Education. 2010;25(3):279-81.
9. Sargeran K, Murtomaa H, Safavi SMR, Vehkalahti M, Teronen O. Malignant oral tumors in Iran: ten-year analysis on patient and tumor characteristics of 1042 patients in Tehran. Journal of Craniofacial Surgery. 2006;17(6):1230-3.
10. Normak W, Reichart P, Philipsen H. Differential diagnosis of oral and maxillofacial lesions. Thieme Medical Publishers; 2000.
11. Lynch MA, Brightman VJ, Greenberg MS. Burket's oral medicine: diagnosis and treatment: Lippincott; 1977.
12. Leao J, Goes P, Sobrinho C, Porter S. Knowledge and clinical expertise regarding oral cancer among Brazilian dentists. International journal of oral and maxillofacial surgery. 2005;34(4):436-9.
13. Horowitz AM, Siriphant P, Sheikh A, CHILD WL. Perspectives of Maryland dentists on oral cancer. The Journal of the American Dental Association. 2001;132(1):65-72.
14. Regezi JA, Sciubba JJ, Jordan RC. Oral pathology: clinical pathologic correlations: Elsevier Health Sciences; 2016.
15. Llewellyn CD, Linklater K, Bell J, Johnson NW, Warnakulasuriya S. An analysis of risk factors for oral cancer in young people: a case-control study. Oral oncology. 2004;40(3):304-13.
16. Chen J, Katz R, Krutch Koff D. Intral oral SCC epidmiologic pattern in connecticiut. Cancer. 1991;66:1288-98.
17. Torossian J-M, Beziat J-L, Philip T, Bejui FT. Squamous cell carcinoma of the tongue in a 13-year- old boy. Journal of oral and maxillofacial surgery. 2000;58(12):1407-10.
18. Chen Y, Huang H, Lin L, Lin C. Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan. Oral oncology. 1999;35(2):173-9.
19. Jansisyanont P, Pazoki A, Ord RA. Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi's anemia. Journal of oral and maxillofacial surgery. 2000;58(12):1454-7.
20. Kuriakose M, Sankaranarayanan M, Nair M, Cherian T, Sugar A, Scully C, et al. Comparison of oral squamous cell carcinoma in younger and older patients in India. European Journal of Cancer Part B: Oral Oncology. 1992;28(2):113-20.
21. Harrison LB, Sessions RB, Hong WK. Head and neck cancer: a multidisciplinary approach: Lippincott Williams & Wilkins; 2009.
22. Cunnane MF. Head and Neck Pathology With Clinical Correlations. Human Pathology. 2001;32(10):1140.
23. Shah JP, Patel SG. Cancer of the head and neck: PMPH-USA; 2001.
24. Brennan JA, Boyle JO, Koch WM, Goodman SN, Hruban RH, Eby YJ, et al. Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck. New England Journal of Medicine. 1995;332(11):712-7.
25. Little JW, Falace D, Miller C, Rhodus NL. Dental Management of the Medically Compromised Patient-Pageburst on VitalSource: Elsevier Health Sciences; 2007.
26. Melo MD, Obeid G. Osteonecrosis of the jaws in patients with a history of receiving bisphosphonate therapy: strategies for prevention and early recognition. The Journal of the American Dental Association. 2005;136(12):1675-81.
27. Ord RA, Blanchaert Jr RH. Oral cancer: The dentist’s role in diagnosis, management,
rehabilitation, and prevention: Chicago; 2000.
| Files | ||
| Issue | Vol 9, No 3 (Summer 2022) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/jcr.v9i3.12700 | |
| Keywords | ||
| Oral squamous cell carcinoma; Survival; Kaplan-meier. | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Garajei A, Pishva S, Emami A. An evaluation on diagnosis and management patterns of patients with oral squamous cell carcinoma referred to the Cancer Institute of Tehran University of Medical Sciences during 2010-2021. J Craniomaxillofac Res. 2023;9(3):144-152.
