Effect of genetic factors on recurrent aphthous in articles published from 2010-2021: A review
,
Abstract
Introduction: The main known factors for causing recurrent oral aphthous are genetics and heredity, hematological defects, and immunological disorders. This study was conducted to review the effect of genetic factors on recurrent oral aphthous. Materials and Methods: This study is a literature review that examines the findings derived from existing research articles investigating the influence of genetic factors on the development of recurrent oral aphthous ulcers. The articles on the same topic were selected from available studies on the web, PubMed ISI, Science, Scopus, and Google Scholar, in 10 years from 2013 to 2022. Articles were chosen and assessed based on specific inclusion and exclusion criteria, employing keywords such as genome, oral, recurrent aphthous, and genetic factor as part of the selection process. Results: 31 studies were selected after screening and based on the inclusion and exclusion criteria. Among them, 1, 2, 3, 2, 5, 5, 6, 3, 3, 1 studies which were done subsequently in the years 2022, 2021, 2020, 2019, 2018, 2017, 2016, 2015, 2014, and 2013, were selected. Among them, 9 studies showed no correlation between genetic factors and RAS incidence, and in the 22 remaining studies, a significant correlation was observed between genetic factors and gene expression in RAS patients compared to healthy people. Conclusion: Genetic factors are effective in the occurrence of recurrent oral aphthous in people.
1. Messadi DV, Younai F. Aphathous ulcer. Dermatologic Therapy 2010; 23(3):281-290.
2. Akinotoye SO, Greenberg MS. Recurrent aphthous stomatitis. Dent Clin North Am 2005.49(1):31-47.
3. Ship JA. Recurrent aphthous stomatitis. An update. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006. 81(2):141-7.
4. Chavan M, Jain H, Diwan N, Khedkar S, Shete A, Durkar S. Rrcurrent aphthous stomatitis: a review. J Oral Pathol Med. 2012;41(8):577-83.
5. Greenberg MS, Glick M, Ship JA. Burkets Oral Medicine. 11th ed. Hamiltin: BC Decker Inc.2008;41-75.
6. Motallebnejad M, Aghel S. The effect of propolis on the total antioxidant capacity of saliva in irradiated rats. Thesis No 14. Dental field. Dental School. Babol University of Medical Sciences; Academic years: 2011.12(4):30-52.
7. Karincaoglu Y, Batcioglu K, Erdem T, Esrefoglu M, Genc M. The levels of plasma and salivary antioxidants in the patient with recurrent aphthous stomatitis. J Oral Pathol Med. 2005;34(1):7-12.
8. Bazrafshani MR, Hajeer AH, Ollier WE, Thornhill MH. Recurrent aphthous stomatitis and gene polymorphisms for the inflammatory markers TNF‐ α, TNF‐ β and the vitamin D receptor: no association detected. Oral diseases. 2002 Nov;8(6):303-7.
9. Borra RC, Andrade PM, Silva ID, Morgun A, Weckx LL, Smirnova AS, Franco M. The Th1/Th2 immune‐ type response of the recurrent aphthous ulceration analyzed by cDNA microarray. Journal of oral pathology & medicine. 2004 Mar;33(3):140-6.
10. Taylor LJ, Bagg J, Walker DM, Peters TJ. Increased production of tumour necrosis factor by peripheral blood leukocytes in patients with recurrent oral aphthous ulceration. Journal of oral pathology & medicine.1992 Jan;21(1):21-5
11. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. The Journal of immunology. 1986 Apr 1;136(7):2348-57.
12. Chiricozzi A, and colleagues. Integrative responses to IL-17 and TNF-alpha in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. j invest drmatol. 2011 Mar,131(3):677-87.
13. Rouvier E, Luciani MF, Mattei MG, Denizot F, Golstein P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. The Journal of Immunology. 1993 Jun 15;150(12):5445-
14. Aggarwal S, Gurney AL. IL‐ 17: prototype member of an emerging cytokine family. Journal of leukocyte biology. 2002 Jan;71(1):1-8.
15. Bartakova J, Deissova T, Slezakova S, Bartova J, Petanova J, Kuklinek P, Fassmann A, Borilova Linhartova P, Dušek L, Izakovicova Holla L. Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case–control study. BMC Oral Health. 2022 Dec;22(1):1-9.
16. Girardelli M, Valencic E, Moressa V, Margagliotta R, Tesser A, Pastore S, Spadola O, Athanasakis E, Severini GM, Taddio A, Tommasini A. Genetic and immunologic findings in children with recurrent aphthous stomatitis with systemic inflammation. Pediatric Rheumatology. 2021 Dec;19(1):1-0.
17. Shabana SJ, Mutawakkil MH, El–Ashmaoui HM, Zahran FM. Interleukin-6 gene polymorphism in Saudi population with recurrent aphthous stomatitis. The Saudi Dental Journal. 2021 Dec 1;33(8):972-8.
18. Nur’aeny N, Gurnida DA, Suwarsa O, Sufiawati I. Serum level of IL-6, reactive oxygen species and cortisol in patients with recurrent aphthous stomatitis related imbalance nutrition intake and atopy. Journal of Mathematical and Fundamental Sciences. 2020 Sep 1;53(3):286-96.
19. Sánchez-Bernal J, Conejero C, Conejero R. Aftosis oral recidivante. Actas DermoSifiliográficas. 2020 Jul 1;111(6):471-80.
20. Slezakova S, Borilova Linhartova P, Bartova J, Petanova J, Kuklinek P, Fassmann A, Dusek L, Izakovicova Holla L. Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. 2020 Mar;49(3):271-7.
21. Zhou Y, Wu J, Wang W, Sun M. Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk. Genes & Immunity. 2019 Jan;20(1):90-101.
22. Kowalska A, Ślebioda Z, Woźniak T, Zasadziński R, Daszkowska M, DorockaBobkowska B. Beta-defensin 1 gene polymorphisms at 5’untranslated region are not associated with a susceptibility to recurrent aphthous stomatitis. Archives of Oral Biology. 2019 May 1;101:130-4.
23. Najafi S, Mohammadzadeh M, Rajabi F, Zare Bidoki A, Yousefi H, Farhadi E, Rezaei N. Interleukin-4 and interleukin-4 receptor alpha gene polymorphisms in recurrent aphthous stomatitis. Immunological Investigations. 2018 Oct 3;47(7):680-8.
24. Najafi S, Mohammadzadeh M, Zahedi A, Heidari M, Rezaei N. Association of serotonin transporter gene polymorphism with recurrent aphthous stomatitis. Avicenna Journal of Medical Biotechnology. 2018 Jan;10(1):56.
25. Bidoki AZ, Massoud A, Najafi S, Mohammadzadeh M, Rezaei N. Autosomal dominant deficiency of the interleukin-17F in recurrent aphthous stomatitis: Possible novel mutation in a new entity.Gene. 2018 May15;654:64-8.
26. Borilova Linhartova P, Janos J, Slezakova S, Bartova J, Petanova J, Kuklinek P, Fassmann A, Dusek L, Izakovicova Holla L. Recurrent aphthous stomatitis and gene variability in selected interleukins: a case–control study. European Journal of Oral Sciences. 2018 Dec;126(6):485-92.
27. Slezakova S, Borilova Linhartova P, Masopustová L, Bartova J, Petanová J, Kuklinek P, Fassmann A, Dusek L, Izakovicova Holla L. Association of the NOD‐like receptor 3(NLRP 3) gene variability with recurrent aphthous stomatitis in the Czech population. Journal of Oral Pathology & Medicine. 2018 Apr;47(4):434-9.
28. Najafi S, Yousefi H, Mohammadzadeh M, Bidoki AZ, Farhadi E, Rezaei N. Interleukin2, interferon-gamma gene polymorphisms in recurrent aphthous stomatitis. Prague medical report. 2017 Sep 19;118(2):81-6.
29. Yousefi H, Najafi S, Mohammadzadeh M, Bidoki AZ, Farhadi E, Rezaei N. Association of Transforming Growth Factor-Beta Gene Polymorphisms in Recurrent Aphthous Stomatitis. Acta Medica Iranica. 2017:672-5.
30. Ślebioda Z, Kowalska A, Rozmiarek M, Krawiecka E, Szponar E, Dorocka-Bobkowska B. The absence of an association between Interleukin 1β gene polymorphisms and recurrent aphthous stomatitis (RAS). Archives of oral biology. 2017 Dec 1;84:45-9.
31. Izakovicova Holla L, Valova S, Borilova Linhartova P, Bartova J, Petanova J, Kuklinek P, Fassmann A. Association study of interleukin‐1 family, interleukin‐6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. 2017 Nov;46(10):1030-5.
32. Yigit S, Tekcan A, Rustemoglu A, Tumer MK, Kalkan G, Yerliyurt K. Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis. Archives of Oral Biology. 2017 Feb 1;74:51-4.
33. Najafi S, Tonkaboni A, Mohammadzadeh M. Assessment of relation between antioxidants level and clinical manifestation in recurrent aphtous stomatitis. Journal of Craniomaxillofacial Research. 2016:157-60.
34. Bidoki AZ, Harsini S, Sadr M, Soltani S, Mohammadzadeh M, Najafi S, Rezaei N. NLRP 3 gene polymorphisms in Iranian patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. 2016 Feb;45(2):136-40.
35. Isaac Firouze M, Shamsolmoulouk N, Mahsa M, Alireza Zare B, Hila Y, Elham F, Arghavan T, Ghasem M, Mohsen M, Ali Akbar A, Nima R. Lack of association between interleukin-12 gene polymorphisms and recurrent aphthous stomatitis.
36. Najafi S, Mohammadzadeh M, Bidoki AZ, Meighani G, Aslani S, Mahmoudi M, Rezaei N. HLA-DRB and HLA-DQB allele and haplotype frequencies in Iranian patients with recurrent aphthous stomatitis. Iranian Journal of Allergy, Asthma and Immunology. 2016 Aug 30:289-95
37. Manchanda A, Iyengar AR, Patil S. Association between serotonin transporter gene polymorphism and recurrent aphthous stomatitis. Dental Research Journal. 2016 May;13(3):206.
38. Jing Z, Jingjing S, Juan G. Relationship between transforming growth factor-β1 and interleukin-10 single nucleotide polymorphism and susceptibility of recurrent aphthous ulcer. Hua xi kou qiang yi xue za zhi= Huaxi kouqiang yixue zazhi= West China journal of stomatology. 2016 Feb 1;34(1):27-31.
39. Najafi S, Yousefi H, Mohammadzadeh M, Bidoki AZ, Firouze Moqadam I, Farhadi E, Amirzargar AA, Rezaei N. Association study of interleukin‐ 1 family and interleukin‐ 6 gene single nucleotide polymorphisms in recurrent aphthous stomatitis. International Journal of Immunogenetics. 2015 Dec;42(6):428-31.
40. Karasneh J, Bani‐ Hani M, Alkhateeb A, Hassan A, Alzoubi F, Thornhill M. TLR 2, TLR 4 and CD 86 gene polymorphisms in recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. 2015 Nov;44(10):857-63.
41. Bidoki AZ, Harsini S, Sadr M, Soltani S, Mohammadzadeh M, Najafi S, Rezaei N. NLRP 3 gene polymorphisms in Iranian patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. 2016 Feb;45(2):136-40.
42. Ślebioda Z, Szponar E, Kowalska A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review. Archivum immunologiae et therapiae experimentalis. 2014 Jun;62(3):205-15.
43. Karakus N, Yigit S, Rustemoglu A, Kalkan G, Bozkurt N. Effects of interleukin (IL)-6 gene polymorphisms on recurrent aphthous stomatitis. Archives of dermatological research. 2014 Mar;306(2):173-80.
44. Najafi S, Firooze Moqadam I, Mohammadzadeh M, Bidoki AZ, Yousefi H, Farhadi E, Tonekaboni A, Meighani G, Amirzargar AA, Rezaei N. Interleukin-10 gene polymorphisms in recurrent aphthous stomatitis. Immunological investigations. 2014 May 1;43(4):405-9.
45. Alkhateeb A, Karasneh J, Abbadi H, Hassan A, Thornhill M. Association of cell adhesion molecule gene polymorphisms with recurrent aphthous stomatitis. Journal of oral pathology & medicine. 2013 Nov;42(10):741-6.
46. Lynch MA, Brightman VJ, Greenberg MS. Burket's oral medicine, diagnosis and treatment. 9th ed. Philadelphia: J.B Lippincott;1994,27-9.
47. Pederson A, Anne C, Bjarnek. T lymphocyte subsets in RAS. J Oral Pathol Med. 2002 Oct;20(10):59-60.
48. Tetsuga Y, Kezunori Y. Serum cytokines IL2 receptor in oral disorders. Oral Surg Oral Med Oral Pathol. 1994 Mar;78(3):727-35.
49. Aggarwal B. Human Cytokines. 3nd ed. Philadelphia: Saunders Co; 2004;36-41.
50. Regina L, Margaret F. Alternation of T helper/inducer in RAS. Oral Surg Oral Med Oral Pathol. 1995 Jan; 83(1):205-8.
51. Austin J, Wood K. Principle of cellular and molecular immunology. 2nd ed. Philadelphia: Saunders Co; 1993; 36-40
52. Sirajedin S, Natabritua M. Immunolocalization of TNF in RAS. J Oral Pathol Med. 2000 Apr;29(4):19-25.
53. James J, Scuibba T. T lymphocyte subset changes in RAS. Oral Surg Oral Med Oral Pathol. 2002 Dec;60(12): 175-81.
54. Lin S, Chou M, Ho C, Yang C. Study of the viral infections and cytokines associated with RAS. Microbes Infect. 2005 Dec;17(3):635-44
2. Akinotoye SO, Greenberg MS. Recurrent aphthous stomatitis. Dent Clin North Am 2005.49(1):31-47.
3. Ship JA. Recurrent aphthous stomatitis. An update. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006. 81(2):141-7.
4. Chavan M, Jain H, Diwan N, Khedkar S, Shete A, Durkar S. Rrcurrent aphthous stomatitis: a review. J Oral Pathol Med. 2012;41(8):577-83.
5. Greenberg MS, Glick M, Ship JA. Burkets Oral Medicine. 11th ed. Hamiltin: BC Decker Inc.2008;41-75.
6. Motallebnejad M, Aghel S. The effect of propolis on the total antioxidant capacity of saliva in irradiated rats. Thesis No 14. Dental field. Dental School. Babol University of Medical Sciences; Academic years: 2011.12(4):30-52.
7. Karincaoglu Y, Batcioglu K, Erdem T, Esrefoglu M, Genc M. The levels of plasma and salivary antioxidants in the patient with recurrent aphthous stomatitis. J Oral Pathol Med. 2005;34(1):7-12.
8. Bazrafshani MR, Hajeer AH, Ollier WE, Thornhill MH. Recurrent aphthous stomatitis and gene polymorphisms for the inflammatory markers TNF‐ α, TNF‐ β and the vitamin D receptor: no association detected. Oral diseases. 2002 Nov;8(6):303-7.
9. Borra RC, Andrade PM, Silva ID, Morgun A, Weckx LL, Smirnova AS, Franco M. The Th1/Th2 immune‐ type response of the recurrent aphthous ulceration analyzed by cDNA microarray. Journal of oral pathology & medicine. 2004 Mar;33(3):140-6.
10. Taylor LJ, Bagg J, Walker DM, Peters TJ. Increased production of tumour necrosis factor by peripheral blood leukocytes in patients with recurrent oral aphthous ulceration. Journal of oral pathology & medicine.1992 Jan;21(1):21-5
11. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. The Journal of immunology. 1986 Apr 1;136(7):2348-57.
12. Chiricozzi A, and colleagues. Integrative responses to IL-17 and TNF-alpha in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. j invest drmatol. 2011 Mar,131(3):677-87.
13. Rouvier E, Luciani MF, Mattei MG, Denizot F, Golstein P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. The Journal of Immunology. 1993 Jun 15;150(12):5445-
14. Aggarwal S, Gurney AL. IL‐ 17: prototype member of an emerging cytokine family. Journal of leukocyte biology. 2002 Jan;71(1):1-8.
15. Bartakova J, Deissova T, Slezakova S, Bartova J, Petanova J, Kuklinek P, Fassmann A, Borilova Linhartova P, Dušek L, Izakovicova Holla L. Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case–control study. BMC Oral Health. 2022 Dec;22(1):1-9.
16. Girardelli M, Valencic E, Moressa V, Margagliotta R, Tesser A, Pastore S, Spadola O, Athanasakis E, Severini GM, Taddio A, Tommasini A. Genetic and immunologic findings in children with recurrent aphthous stomatitis with systemic inflammation. Pediatric Rheumatology. 2021 Dec;19(1):1-0.
17. Shabana SJ, Mutawakkil MH, El–Ashmaoui HM, Zahran FM. Interleukin-6 gene polymorphism in Saudi population with recurrent aphthous stomatitis. The Saudi Dental Journal. 2021 Dec 1;33(8):972-8.
18. Nur’aeny N, Gurnida DA, Suwarsa O, Sufiawati I. Serum level of IL-6, reactive oxygen species and cortisol in patients with recurrent aphthous stomatitis related imbalance nutrition intake and atopy. Journal of Mathematical and Fundamental Sciences. 2020 Sep 1;53(3):286-96.
19. Sánchez-Bernal J, Conejero C, Conejero R. Aftosis oral recidivante. Actas DermoSifiliográficas. 2020 Jul 1;111(6):471-80.
20. Slezakova S, Borilova Linhartova P, Bartova J, Petanova J, Kuklinek P, Fassmann A, Dusek L, Izakovicova Holla L. Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. 2020 Mar;49(3):271-7.
21. Zhou Y, Wu J, Wang W, Sun M. Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk. Genes & Immunity. 2019 Jan;20(1):90-101.
22. Kowalska A, Ślebioda Z, Woźniak T, Zasadziński R, Daszkowska M, DorockaBobkowska B. Beta-defensin 1 gene polymorphisms at 5’untranslated region are not associated with a susceptibility to recurrent aphthous stomatitis. Archives of Oral Biology. 2019 May 1;101:130-4.
23. Najafi S, Mohammadzadeh M, Rajabi F, Zare Bidoki A, Yousefi H, Farhadi E, Rezaei N. Interleukin-4 and interleukin-4 receptor alpha gene polymorphisms in recurrent aphthous stomatitis. Immunological Investigations. 2018 Oct 3;47(7):680-8.
24. Najafi S, Mohammadzadeh M, Zahedi A, Heidari M, Rezaei N. Association of serotonin transporter gene polymorphism with recurrent aphthous stomatitis. Avicenna Journal of Medical Biotechnology. 2018 Jan;10(1):56.
25. Bidoki AZ, Massoud A, Najafi S, Mohammadzadeh M, Rezaei N. Autosomal dominant deficiency of the interleukin-17F in recurrent aphthous stomatitis: Possible novel mutation in a new entity.Gene. 2018 May15;654:64-8.
26. Borilova Linhartova P, Janos J, Slezakova S, Bartova J, Petanova J, Kuklinek P, Fassmann A, Dusek L, Izakovicova Holla L. Recurrent aphthous stomatitis and gene variability in selected interleukins: a case–control study. European Journal of Oral Sciences. 2018 Dec;126(6):485-92.
27. Slezakova S, Borilova Linhartova P, Masopustová L, Bartova J, Petanová J, Kuklinek P, Fassmann A, Dusek L, Izakovicova Holla L. Association of the NOD‐like receptor 3(NLRP 3) gene variability with recurrent aphthous stomatitis in the Czech population. Journal of Oral Pathology & Medicine. 2018 Apr;47(4):434-9.
28. Najafi S, Yousefi H, Mohammadzadeh M, Bidoki AZ, Farhadi E, Rezaei N. Interleukin2, interferon-gamma gene polymorphisms in recurrent aphthous stomatitis. Prague medical report. 2017 Sep 19;118(2):81-6.
29. Yousefi H, Najafi S, Mohammadzadeh M, Bidoki AZ, Farhadi E, Rezaei N. Association of Transforming Growth Factor-Beta Gene Polymorphisms in Recurrent Aphthous Stomatitis. Acta Medica Iranica. 2017:672-5.
30. Ślebioda Z, Kowalska A, Rozmiarek M, Krawiecka E, Szponar E, Dorocka-Bobkowska B. The absence of an association between Interleukin 1β gene polymorphisms and recurrent aphthous stomatitis (RAS). Archives of oral biology. 2017 Dec 1;84:45-9.
31. Izakovicova Holla L, Valova S, Borilova Linhartova P, Bartova J, Petanova J, Kuklinek P, Fassmann A. Association study of interleukin‐1 family, interleukin‐6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. 2017 Nov;46(10):1030-5.
32. Yigit S, Tekcan A, Rustemoglu A, Tumer MK, Kalkan G, Yerliyurt K. Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis. Archives of Oral Biology. 2017 Feb 1;74:51-4.
33. Najafi S, Tonkaboni A, Mohammadzadeh M. Assessment of relation between antioxidants level and clinical manifestation in recurrent aphtous stomatitis. Journal of Craniomaxillofacial Research. 2016:157-60.
34. Bidoki AZ, Harsini S, Sadr M, Soltani S, Mohammadzadeh M, Najafi S, Rezaei N. NLRP 3 gene polymorphisms in Iranian patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. 2016 Feb;45(2):136-40.
35. Isaac Firouze M, Shamsolmoulouk N, Mahsa M, Alireza Zare B, Hila Y, Elham F, Arghavan T, Ghasem M, Mohsen M, Ali Akbar A, Nima R. Lack of association between interleukin-12 gene polymorphisms and recurrent aphthous stomatitis.
36. Najafi S, Mohammadzadeh M, Bidoki AZ, Meighani G, Aslani S, Mahmoudi M, Rezaei N. HLA-DRB and HLA-DQB allele and haplotype frequencies in Iranian patients with recurrent aphthous stomatitis. Iranian Journal of Allergy, Asthma and Immunology. 2016 Aug 30:289-95
37. Manchanda A, Iyengar AR, Patil S. Association between serotonin transporter gene polymorphism and recurrent aphthous stomatitis. Dental Research Journal. 2016 May;13(3):206.
38. Jing Z, Jingjing S, Juan G. Relationship between transforming growth factor-β1 and interleukin-10 single nucleotide polymorphism and susceptibility of recurrent aphthous ulcer. Hua xi kou qiang yi xue za zhi= Huaxi kouqiang yixue zazhi= West China journal of stomatology. 2016 Feb 1;34(1):27-31.
39. Najafi S, Yousefi H, Mohammadzadeh M, Bidoki AZ, Firouze Moqadam I, Farhadi E, Amirzargar AA, Rezaei N. Association study of interleukin‐ 1 family and interleukin‐ 6 gene single nucleotide polymorphisms in recurrent aphthous stomatitis. International Journal of Immunogenetics. 2015 Dec;42(6):428-31.
40. Karasneh J, Bani‐ Hani M, Alkhateeb A, Hassan A, Alzoubi F, Thornhill M. TLR 2, TLR 4 and CD 86 gene polymorphisms in recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. 2015 Nov;44(10):857-63.
41. Bidoki AZ, Harsini S, Sadr M, Soltani S, Mohammadzadeh M, Najafi S, Rezaei N. NLRP 3 gene polymorphisms in Iranian patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine. 2016 Feb;45(2):136-40.
42. Ślebioda Z, Szponar E, Kowalska A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review. Archivum immunologiae et therapiae experimentalis. 2014 Jun;62(3):205-15.
43. Karakus N, Yigit S, Rustemoglu A, Kalkan G, Bozkurt N. Effects of interleukin (IL)-6 gene polymorphisms on recurrent aphthous stomatitis. Archives of dermatological research. 2014 Mar;306(2):173-80.
44. Najafi S, Firooze Moqadam I, Mohammadzadeh M, Bidoki AZ, Yousefi H, Farhadi E, Tonekaboni A, Meighani G, Amirzargar AA, Rezaei N. Interleukin-10 gene polymorphisms in recurrent aphthous stomatitis. Immunological investigations. 2014 May 1;43(4):405-9.
45. Alkhateeb A, Karasneh J, Abbadi H, Hassan A, Thornhill M. Association of cell adhesion molecule gene polymorphisms with recurrent aphthous stomatitis. Journal of oral pathology & medicine. 2013 Nov;42(10):741-6.
46. Lynch MA, Brightman VJ, Greenberg MS. Burket's oral medicine, diagnosis and treatment. 9th ed. Philadelphia: J.B Lippincott;1994,27-9.
47. Pederson A, Anne C, Bjarnek. T lymphocyte subsets in RAS. J Oral Pathol Med. 2002 Oct;20(10):59-60.
48. Tetsuga Y, Kezunori Y. Serum cytokines IL2 receptor in oral disorders. Oral Surg Oral Med Oral Pathol. 1994 Mar;78(3):727-35.
49. Aggarwal B. Human Cytokines. 3nd ed. Philadelphia: Saunders Co; 2004;36-41.
50. Regina L, Margaret F. Alternation of T helper/inducer in RAS. Oral Surg Oral Med Oral Pathol. 1995 Jan; 83(1):205-8.
51. Austin J, Wood K. Principle of cellular and molecular immunology. 2nd ed. Philadelphia: Saunders Co; 1993; 36-40
52. Sirajedin S, Natabritua M. Immunolocalization of TNF in RAS. J Oral Pathol Med. 2000 Apr;29(4):19-25.
53. James J, Scuibba T. T lymphocyte subset changes in RAS. Oral Surg Oral Med Oral Pathol. 2002 Dec;60(12): 175-81.
54. Lin S, Chou M, Ho C, Yang C. Study of the viral infections and cytokines associated with RAS. Microbes Infect. 2005 Dec;17(3):635-44
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| Issue | Vol 10, No 1 (Winter 2023) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/jcr.v10i1.13673 | |
| Keywords | ||
| Recurrent oral aphthous; Genetic factors; Genome. | ||
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How to Cite
1.
Najafi S, Pourheydar P, Taheri L, Goudarzi M. Effect of genetic factors on recurrent aphthous in articles published from 2010-2021: A review. J Craniomaxillofac Res. 2023;10(1):1-8.
