The Effect of Vitamins and Minerals on Dental Implants: A Review
Abstract
Introduction: The focus of this review study was to examine and analyze the impact of vitamins and minerals on dental implants. Materials and Methods: In order to obtain information on the effects of vitamins and minerals on dental implants, a group of existing articles was thoroughly examined for their findings. This examination process involved the selection of specific articles that met the necessary criteria to be included in the analysis, which were then subjected to an extensive review process. The duration of this review process was over a time span of 11 years, starting from the year 2011 and concluding in the year 2022.Results: A total of 23 articles were included in the study, consisting of 9 clinical studies, 6 animal studies, 1 laboratory study, and 7 reviews. Clinical studies were limited due to uncertain results regarding the impact of vitamins and minerals on DIT, with most focusing on vitamin D levels rather than other nutrients.Conclusion: It has been concluded that vitamins and minerals play an important role in forming bone tissue. The lack of these essential elements may result in several diseases, such as diabetes mellitus and osteoporosis. It is therefore recommended to increase the levels of vitamins and minerals in patients before undergoing dental implant treatment (DIT), even though the quality of the patient’s bone can also impact the success of the implant. Consequently, the patient’s diet should be modified, and essential supplements and vitamins should be administered to ensure optimal implant success.Keywords: Vitamins; Minerals; Vitamin D; Calcium; Dental implants; Osseointegration.
1. Monje A, Nart J. Management and sequelae of dental implant removal. Periodontol 2000. 2022;88(1):182-200.
2. Shirazi S, Ravindran S, Cooper LF. Topography-mediated immunomodulation in osseointegration; Ally or Enemy. Biomaterials. 2022 9:121903.
3. Mangano FG, Oskouei SG, Paz A, Mangano N, Mangano C. Low serum vitamin D and early dental implant failure: Is there a connection? A retrospective clinical study on 1740 implants placed in 885 patients. J Dent Res Dent Clin Dent Prospects. 2018;12(3):174.
4. Kang MH, Lee SJ, Lee MH. Bone remodeling effects of Korean Red Ginseng extracts for dental implant applications. J Ginseng Res. 2020 1;44(6):823-32.
5. Sawyer H. The role of ascorbic acid, osteoblast seeding, and insulin on bone formation in novel in-vivo bone model, Doctoral dissertation, Boston University, 2021.
6. Wallace TC. Combating COVID-19 and building immune resilience: a potential role for magnesium nutrition?. J Am Coll Nutr. 2020 16;39(8):685-93.
7. Kaseem M, Choe HC. Acceleration of bone formation and adhesion ability on dental implant surface via plasma electrolytic oxidation in a solution containing bone ions. Metals. 2021 7;11(1):106.
8. Rafiei H, Sobhani B. Bone Marrow Mesenchymal Stem Cells Differentiation after Feeding Rats with Magnesium Chloride: Potential Journey toward Osteogenic Microcosm?. American Journal of Stem Cell Research. 2022;4(1):1-7.
9. Acipinar S, Karsiyaka Hendek M, Olgun E, Kisa U. Evaluation of FGF‐23 and 25 (OH) D3 levels in peri‐implant sulcus fluid in peri‐implant health and diseases. Clin Implant Dent Relat Res. 2019;21(5):1106-12.
10. Pesce P, Menini M, Tommasato G, Patini R, Canullo L. Influence of modified titanium abutment surface on peri-implant soft tissue behaviour: a systematic review of histological findings. Int J Oral Implantol. 2019;12(4):419-29.
11. Singh A, Agarwal M, Prasad A. Assessment of correlation of Low serum vitamin D and early dental implant failure. Journal of Advanced Medical and Dental Sciences Research. 2020;8(1).
12. Tański W, Kosiorowska J, Szymańska-Chabowska A. Osteoporosis-risk factors, pharmaceutical and non-pharmaceutical treatment. Eur Rev Med Pharmacol Sci. 2021 1;25(9):3557-66.
13. Delbar A, Pflimlin A, Delabrière I, Ternynck C, Chantelot C, Puisieux F, Cortet B, Paccou J. Persistence with osteoporosis treatment in patients from the Lille University Hospital Fracture Liaison Service. Bone. 2021 1;144:115838.
14. Okamura H, Ishikawa K, Kudo Y, Matsuoka A, Maruyama H, Emori H, Yamamura R, Hayakawa C, Tani S, Tsuchiya K, Shirahata T. Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study. PLoS One. 2020 7;15(8):e0237454.
15. Kwiatek, J.; Jaro´n, A.; Trybek, G. Impact of the 25-Hydroxycholecalciferol Concentration and Vitamin D Deficiency Treatment on Changes in the Bone Level at the Implant Site during the Process of Osseointegration: A Prospective, Randomized, Controlled Clinical Trial. J Clin Med. 2021, 10, 526.
16. Tabrizi, R.; Mohajerani, H.; Jafari, S.; Tümer, M.K. Does the serum level of vitamin D affect marginal bone loss around dentalimplants? Int J Oral Maxillofac Surg. 2021, 51, 832–836.
17. Diachkova E, Abramova EV, Blagushina NA, Tarasenko S. Surgical treatment with dental implants in a patient with secondary loss of teeth and osteoporosis caused by an imbalance of vitamin D. BMJ Case Rep CP. 2020 1;13(11):e235585.
18. Garg, P.; Ghalaut, P.; Dahiya, K.; Ravi, R.; Sharma, A.; Wakure, P. Comparative evaluation of crestal bone level in patients having low level of Vitamin D treated with dental implant with or without Vitamin D3 supplements. Natl. J Maxillofac Surg. 2020, 11, 199–206.
19. Li X, Tang L, Lin YF, Xie GF. Role of vitamin C in wound healing after dental implant surgery in patients treated with bone grafts and patients with chronic periodontitis. Clin Implant Dent Relat Res. 2018;20(5):793-8.
20. Bryce G, MacBeth N. Vitamin D deficiency as a suspected causative factor in the failure of an immediately placed dental implant: a case report. J R Nav Med Serv. 2014 1;100(3).
21. Salomó‐Coll O, Maté‐Sánchez de Val JE, Ramírez‐Fernandez MP, Hernández‐Alfaro F, Gargallo‐Albiol J, Calvo‐Guirado JL. Topical applications of vitamin D on implant surface for bone‐to‐implant contact enhance: a pilot study in dogs part II. Clin Oral Implants Res. 2016;27(7):896-903.
22. Liu W, Zhang S, Zhao D, Zou H, Sun N, Liang X, Dard M, Lanske B, Yuan Q. Vitamin D supplementation enhances the fixation of titanium implants in chronic kidney disease mice. PloS one. 2014 21;9(4):e95689.
23. Wu YY, Yu T, Yang XY, Li F, Ma L, Yang Y, Liu XG, Wang YY, Gong P. Vitamin D3 and insulin combined treatment promotes titanium implant osseointegration in diabetes mellitus rats. Bone. 2013 1;52(1):1-8.
24. Akhavan A, Noroozi Z, Shafiei AA, Haghighat A, Jahanshahi GR, Mousavi SB. The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats. Dent Res J (Isfahan). 2012 ;9(5):582.
25. Zhou C, Li Y, Wang X, Shui X, Hu J. 1, 25Dihydroxy vitamin D3 improves titanium implant osseointegration in osteoporotic rats. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 1;114(5):S174-8.
26. Abosaooda M, Wajdy JM, Hussein EA, Jalil AT, Kadhim MM, Abdullah MM, Hamed AH, Almashhadani HA. Role of vitamin C in the protection of the gum and implants in the human body: theoretical and experimental studies. Int J Corros. 2021;10(3):1213-29.
27. Martelli FS, Martelli M, Rosati C, Fanti E. Vitamin D: relevance in dental practice. Clin Cases Miner Bone Metab. 2014 ;11(1):15.
28. Hakim LK, Ghasemi T, Bashar S, Dortaj D. The Possible Role of Vitamin D Deficiency in Early Implant Failure. BioMed Res Int. 2021;2021.
29. Nastri L, Moretti A, Migliaccio S, Paoletta M, Annunziata M, Liguori S, Toro G, Bianco M, Cecoro G, Guida L, Iolascon G. Do dietary supplements and nutraceuticals have effects on dental implant osseointegration? A scoping review. Nutrients. 2020 ;12(1):268.
30. Vesala AM, Dontas I. The role of vitamin D in dental implants osseointegration. J Res Pract Musculoskeletal Syst. 2020 1;4(1):1-7.
31. Trybek G, Aniko-Wlodarczyk M, Kwiatek J, Preuss O, Brodkiewicz A, Sinicyn A, et al. The effect of vitamin D3 on the osteointegration of dental implant. Balt J Health Phys Act. 2018;10:25-33.
32. Yu Y, Jin G, Xue Y, Wang D, Liu X, Sun J. Multifunctions of dual Zn/Mg ion co-implanted titanium on osteogenesis, angiogenesis and bacteria inhibition for dental implants. Acta biomater. 2017 1;49:590-603.
33. Javed F, Malmstrom H, Kellesarian SV, Al-Kheraif AA, Vohra F, Romanos GE. Efficacy of vitamin D3 supplementation on osseointegration of implants. Implant Dent. 2016 1;25(2):281-7
34. Pouran Famili, Jennifer M. Zavoral; Low Skeletal Bone Mineral Density Does Not Affect Dental Implants. J Oral Implantol 2015; 41 (5): 550–553. doi: https://doi.org/10.1563/aaid-joi-D-13-00282
35. Gaetti-Jardim EC, Santiago-Junior JF, Goiato MC, Pellizer EP, Magro-Filho O, Elerson Gaetti Jardim J. Dental implants in patients with osteoporosis: a clinical reality? J Craniofac Surg. 2011;22(3):1111-3
36. Saba Mohammadi., et al. “A Review of the Success Rate of Dental Implants in Patients Undergoing Radiotherapy and Chemotherapy". Acta Sci Otolaryngol. 4.4 (2022): 39-47.
37. Chapple IL, Matthews JB, Wright HJ, Scott AE, Griffiths HR, Grant MM. Ascorbate and α-tocopherol differentially modulate reactive oxygenspecies generation by neutrophils in response to FcγR and TLR agonists. Innate immunity. 2013;19(2):152-159.
38. Galindo-Moreno P, Leon-Cano A, Ortega-Oller I, Monje A, F OV, Catena A. Marginal bone loss as success criterion in implant dentistry: beyond 2 mm. Clin Oral Implants Res. 2015;26:e28–6.
39. Razmara F, Kazemian M. Etiology, complications, key systemic and environmental risk factors in dental implant failure. Int J Contemp Dent Med Rev. 2015;81:1-6.
40. Wagner F, Schuder K, Hof M, Heuberer S, Seemann R, Dvorak G. Does osteoporosis influence the marginal peri-implant bone level in female patients? A cross-sectional study in a matched collective. Clin Implant Dent Relat Res. 2017;19:616–7.
41. Jonasson G, Rythen M. Alveolar bone loss in osteoporosis: a loaded and cellular affair? Clin Cosmet Investig Dent. 2016;8:95–8.
42. Makker A, Singh MM, Mishra G, Singh BP, Jain GK, Jadhav S. Relationship between bone turnover biomarkers, mandibular bone mineral density, and systemic skeletal bone mineral density in premenopausal and postmenopausal Indian women. Menopause. 2012;19:642–9.
43. Zhao JG, Zeng XT, Wang J, Liu L. Association between calcium or vitamin D supplementation and fracture incidence in community-dwelling older adults: a systematic review and metaanalysis. JAMA. 2017;318:2466–22.
44. Ahmed Yaseen Alqutaibi, Iman Abd-Elwahab Radi. No Clear Evidence Regarding the Effect of Osteoporosis on Dental Implant Failure. J Evid Based Dent Pract. 2016;16(2):124-126.
45. Mikhail FF, El-Din M, Ibrahim T, Zekry K, Nemat A, Nasry S. Effect of laser therapy on the osseointegration of immediately loaded dental implants in patients under vitamin C, omega-3 and calcium therapy. Open Access Maced J Med Sci. 2019 20;6(8):1468.
2. Shirazi S, Ravindran S, Cooper LF. Topography-mediated immunomodulation in osseointegration; Ally or Enemy. Biomaterials. 2022 9:121903.
3. Mangano FG, Oskouei SG, Paz A, Mangano N, Mangano C. Low serum vitamin D and early dental implant failure: Is there a connection? A retrospective clinical study on 1740 implants placed in 885 patients. J Dent Res Dent Clin Dent Prospects. 2018;12(3):174.
4. Kang MH, Lee SJ, Lee MH. Bone remodeling effects of Korean Red Ginseng extracts for dental implant applications. J Ginseng Res. 2020 1;44(6):823-32.
5. Sawyer H. The role of ascorbic acid, osteoblast seeding, and insulin on bone formation in novel in-vivo bone model, Doctoral dissertation, Boston University, 2021.
6. Wallace TC. Combating COVID-19 and building immune resilience: a potential role for magnesium nutrition?. J Am Coll Nutr. 2020 16;39(8):685-93.
7. Kaseem M, Choe HC. Acceleration of bone formation and adhesion ability on dental implant surface via plasma electrolytic oxidation in a solution containing bone ions. Metals. 2021 7;11(1):106.
8. Rafiei H, Sobhani B. Bone Marrow Mesenchymal Stem Cells Differentiation after Feeding Rats with Magnesium Chloride: Potential Journey toward Osteogenic Microcosm?. American Journal of Stem Cell Research. 2022;4(1):1-7.
9. Acipinar S, Karsiyaka Hendek M, Olgun E, Kisa U. Evaluation of FGF‐23 and 25 (OH) D3 levels in peri‐implant sulcus fluid in peri‐implant health and diseases. Clin Implant Dent Relat Res. 2019;21(5):1106-12.
10. Pesce P, Menini M, Tommasato G, Patini R, Canullo L. Influence of modified titanium abutment surface on peri-implant soft tissue behaviour: a systematic review of histological findings. Int J Oral Implantol. 2019;12(4):419-29.
11. Singh A, Agarwal M, Prasad A. Assessment of correlation of Low serum vitamin D and early dental implant failure. Journal of Advanced Medical and Dental Sciences Research. 2020;8(1).
12. Tański W, Kosiorowska J, Szymańska-Chabowska A. Osteoporosis-risk factors, pharmaceutical and non-pharmaceutical treatment. Eur Rev Med Pharmacol Sci. 2021 1;25(9):3557-66.
13. Delbar A, Pflimlin A, Delabrière I, Ternynck C, Chantelot C, Puisieux F, Cortet B, Paccou J. Persistence with osteoporosis treatment in patients from the Lille University Hospital Fracture Liaison Service. Bone. 2021 1;144:115838.
14. Okamura H, Ishikawa K, Kudo Y, Matsuoka A, Maruyama H, Emori H, Yamamura R, Hayakawa C, Tani S, Tsuchiya K, Shirahata T. Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study. PLoS One. 2020 7;15(8):e0237454.
15. Kwiatek, J.; Jaro´n, A.; Trybek, G. Impact of the 25-Hydroxycholecalciferol Concentration and Vitamin D Deficiency Treatment on Changes in the Bone Level at the Implant Site during the Process of Osseointegration: A Prospective, Randomized, Controlled Clinical Trial. J Clin Med. 2021, 10, 526.
16. Tabrizi, R.; Mohajerani, H.; Jafari, S.; Tümer, M.K. Does the serum level of vitamin D affect marginal bone loss around dentalimplants? Int J Oral Maxillofac Surg. 2021, 51, 832–836.
17. Diachkova E, Abramova EV, Blagushina NA, Tarasenko S. Surgical treatment with dental implants in a patient with secondary loss of teeth and osteoporosis caused by an imbalance of vitamin D. BMJ Case Rep CP. 2020 1;13(11):e235585.
18. Garg, P.; Ghalaut, P.; Dahiya, K.; Ravi, R.; Sharma, A.; Wakure, P. Comparative evaluation of crestal bone level in patients having low level of Vitamin D treated with dental implant with or without Vitamin D3 supplements. Natl. J Maxillofac Surg. 2020, 11, 199–206.
19. Li X, Tang L, Lin YF, Xie GF. Role of vitamin C in wound healing after dental implant surgery in patients treated with bone grafts and patients with chronic periodontitis. Clin Implant Dent Relat Res. 2018;20(5):793-8.
20. Bryce G, MacBeth N. Vitamin D deficiency as a suspected causative factor in the failure of an immediately placed dental implant: a case report. J R Nav Med Serv. 2014 1;100(3).
21. Salomó‐Coll O, Maté‐Sánchez de Val JE, Ramírez‐Fernandez MP, Hernández‐Alfaro F, Gargallo‐Albiol J, Calvo‐Guirado JL. Topical applications of vitamin D on implant surface for bone‐to‐implant contact enhance: a pilot study in dogs part II. Clin Oral Implants Res. 2016;27(7):896-903.
22. Liu W, Zhang S, Zhao D, Zou H, Sun N, Liang X, Dard M, Lanske B, Yuan Q. Vitamin D supplementation enhances the fixation of titanium implants in chronic kidney disease mice. PloS one. 2014 21;9(4):e95689.
23. Wu YY, Yu T, Yang XY, Li F, Ma L, Yang Y, Liu XG, Wang YY, Gong P. Vitamin D3 and insulin combined treatment promotes titanium implant osseointegration in diabetes mellitus rats. Bone. 2013 1;52(1):1-8.
24. Akhavan A, Noroozi Z, Shafiei AA, Haghighat A, Jahanshahi GR, Mousavi SB. The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats. Dent Res J (Isfahan). 2012 ;9(5):582.
25. Zhou C, Li Y, Wang X, Shui X, Hu J. 1, 25Dihydroxy vitamin D3 improves titanium implant osseointegration in osteoporotic rats. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 1;114(5):S174-8.
26. Abosaooda M, Wajdy JM, Hussein EA, Jalil AT, Kadhim MM, Abdullah MM, Hamed AH, Almashhadani HA. Role of vitamin C in the protection of the gum and implants in the human body: theoretical and experimental studies. Int J Corros. 2021;10(3):1213-29.
27. Martelli FS, Martelli M, Rosati C, Fanti E. Vitamin D: relevance in dental practice. Clin Cases Miner Bone Metab. 2014 ;11(1):15.
28. Hakim LK, Ghasemi T, Bashar S, Dortaj D. The Possible Role of Vitamin D Deficiency in Early Implant Failure. BioMed Res Int. 2021;2021.
29. Nastri L, Moretti A, Migliaccio S, Paoletta M, Annunziata M, Liguori S, Toro G, Bianco M, Cecoro G, Guida L, Iolascon G. Do dietary supplements and nutraceuticals have effects on dental implant osseointegration? A scoping review. Nutrients. 2020 ;12(1):268.
30. Vesala AM, Dontas I. The role of vitamin D in dental implants osseointegration. J Res Pract Musculoskeletal Syst. 2020 1;4(1):1-7.
31. Trybek G, Aniko-Wlodarczyk M, Kwiatek J, Preuss O, Brodkiewicz A, Sinicyn A, et al. The effect of vitamin D3 on the osteointegration of dental implant. Balt J Health Phys Act. 2018;10:25-33.
32. Yu Y, Jin G, Xue Y, Wang D, Liu X, Sun J. Multifunctions of dual Zn/Mg ion co-implanted titanium on osteogenesis, angiogenesis and bacteria inhibition for dental implants. Acta biomater. 2017 1;49:590-603.
33. Javed F, Malmstrom H, Kellesarian SV, Al-Kheraif AA, Vohra F, Romanos GE. Efficacy of vitamin D3 supplementation on osseointegration of implants. Implant Dent. 2016 1;25(2):281-7
34. Pouran Famili, Jennifer M. Zavoral; Low Skeletal Bone Mineral Density Does Not Affect Dental Implants. J Oral Implantol 2015; 41 (5): 550–553. doi: https://doi.org/10.1563/aaid-joi-D-13-00282
35. Gaetti-Jardim EC, Santiago-Junior JF, Goiato MC, Pellizer EP, Magro-Filho O, Elerson Gaetti Jardim J. Dental implants in patients with osteoporosis: a clinical reality? J Craniofac Surg. 2011;22(3):1111-3
36. Saba Mohammadi., et al. “A Review of the Success Rate of Dental Implants in Patients Undergoing Radiotherapy and Chemotherapy". Acta Sci Otolaryngol. 4.4 (2022): 39-47.
37. Chapple IL, Matthews JB, Wright HJ, Scott AE, Griffiths HR, Grant MM. Ascorbate and α-tocopherol differentially modulate reactive oxygenspecies generation by neutrophils in response to FcγR and TLR agonists. Innate immunity. 2013;19(2):152-159.
38. Galindo-Moreno P, Leon-Cano A, Ortega-Oller I, Monje A, F OV, Catena A. Marginal bone loss as success criterion in implant dentistry: beyond 2 mm. Clin Oral Implants Res. 2015;26:e28–6.
39. Razmara F, Kazemian M. Etiology, complications, key systemic and environmental risk factors in dental implant failure. Int J Contemp Dent Med Rev. 2015;81:1-6.
40. Wagner F, Schuder K, Hof M, Heuberer S, Seemann R, Dvorak G. Does osteoporosis influence the marginal peri-implant bone level in female patients? A cross-sectional study in a matched collective. Clin Implant Dent Relat Res. 2017;19:616–7.
41. Jonasson G, Rythen M. Alveolar bone loss in osteoporosis: a loaded and cellular affair? Clin Cosmet Investig Dent. 2016;8:95–8.
42. Makker A, Singh MM, Mishra G, Singh BP, Jain GK, Jadhav S. Relationship between bone turnover biomarkers, mandibular bone mineral density, and systemic skeletal bone mineral density in premenopausal and postmenopausal Indian women. Menopause. 2012;19:642–9.
43. Zhao JG, Zeng XT, Wang J, Liu L. Association between calcium or vitamin D supplementation and fracture incidence in community-dwelling older adults: a systematic review and metaanalysis. JAMA. 2017;318:2466–22.
44. Ahmed Yaseen Alqutaibi, Iman Abd-Elwahab Radi. No Clear Evidence Regarding the Effect of Osteoporosis on Dental Implant Failure. J Evid Based Dent Pract. 2016;16(2):124-126.
45. Mikhail FF, El-Din M, Ibrahim T, Zekry K, Nemat A, Nasry S. Effect of laser therapy on the osseointegration of immediately loaded dental implants in patients under vitamin C, omega-3 and calcium therapy. Open Access Maced J Med Sci. 2019 20;6(8):1468.
| Files | ||
| Issue | Vol 11, No 1 (Winter 2024) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/jcr.v11i1.16475 | |
| Keywords | ||
| Vitamins Minerals Vitamin D; Calcium Dental implants Osseointegration | ||
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How to Cite
1.
Razmara F, Razmara D, Tayari N, Mohammadi S. The Effect of Vitamins and Minerals on Dental Implants: A Review. J Craniomaxillofac Res. 2024;11(1):1-8.
