Efficacy of Blood Factors for Treatment of Temporomandibular Disorders: A Review
-
Akram Ghannadpour
,
Shahab Honar
,
Ahmad Toumaj
,
Seyedeh Paniz Mousavi Sangsaraki
,
Farnoosh Razmara
Abstract
Introduction: To date, no consensus has been reached on one single efficient treatment for temporomandibular disorders (TMDs). Considering the existing controversy regarding the efficacy of blood factors for the treatment of TMDs, this study aimed to do a comprehensive review of the efficacy of blood factors for the treatment of TMDs. Materials and Methods: In this review study PubMed, ISI Web of Science, and Scopus databases were searched for articles published from 2012 to 2023 using platelet-rich plasma (PRP), platelet-rich fibrin (PRF), injection, temporomandibular joint (TMJ) disorders, blood supply, and blood as keywords. Eligible articles were included and reviewed. Results: Nineteen eligible articles were reviewed, of which, TMJ pain had been evaluated in 10, ankylosis in 9, disc displacement in 5, and disc dislocation in 3 studies. The remaining studies evaluated other TMJ problems such as clicking, dull maxillofacial pains, ear pain, referred pain in teeth, and lockjaw. TMJ pain and ankylosis had the highest frequency among different TMJ problems. The most commonly adopted frequency of injections was 5 times as reported in 8 studies. Conclusion: PRP and PRF had optimal efficacy for the reduction and resolution of TMD symptoms especially severe TMJ pain, ankylosis, disc displacement, and disc dislocation. PRP and PRF showed comparable efficacy for this purpose, and the efficacy of PRP and PRF injections for treatment of TMDs was considerably higher than other materials/methods such as chitosan, arthrocentesis, hyaluronic acid, isotonic saline, and hydrocortisone. Five injections appear to be efficient in achieving optimal therapeutic results. Keywords: Blood factors; Temporomandibular disorders; Platelet-rich plasma; Platelet-rich fibrin.
1. Kaur B, Sehgal R, Logani A, Dhar P. Morphometric evaluation of temporomandibular joint using cone beam computed tomography (CBCT). Am J Oral Med Radiol. 2015;2(4):169-76.
2. Iturriaga V, Bornhardt T, Velasquez N. Temporomandibular Joint: Review of Anatomy and Clinical Implications. Dent Clin North Am. 2023 Apr;67(2):199-209.
3. Gutiérrez IQ, Sábado-Bundó H, Gay-Escoda C. Intraarticular injections of platelet rich plasma and plasma rich in growth factors with arthrocenthesis or arthroscopy in the treatment of temporomandibular joint disorders: A systematic review. J Stomatol Oral Maxillofac Surg. 2022 Oct;123(5):e327-e35.
4. Haddad C, Zoghbi A, El Skaff E, Touma J. Platelet-rich plasma injections for the treatment of temporomandibular joint disorders: A systematic review. J Oral Rehabil. 2023 Jun 21:1-12.
5. Xu J, Ren H, Zhao S, Li Q, Li C, Bao G, et al. Comparative effectiveness of hyaluronic acid, platelet-rich plasma, and platelet-rich fibrin in treating temporomandibular disorders: a systematic review and network meta-analysis. Head Face Med. 2023 Aug 26;19(1):39.
6. Nemeth A, Gurgel BV, Lowenstein A, Juliasse L, Siroma RS, Zhu Z, et al. Does Liquid/Injectable Platelet-Rich Fibrin Help in the Arthrocentesis Treatment of Temporomandibular Joint Disorder Compared to Other Infusion Options? A Systematic Review of Randomized Clinical Trials. Bioengineering. 2024;11(3):247.
7. Işık G, Kenç S, Özveri Koyuncu B, Günbay S, Günbay T. Injectable platelet-rich fibrin as treatment for temporomandibular joint osteoarthritis: A randomized controlled clinical trial. J Craniomaxillofac Surg. 2022 Jul;50(7):576-82.
8. Sikora M, Sielski M, Chęciński M, Nowak Z, Czerwińska-Niezabitowska B, Chlubek D. Repeated Intra-Articular Administration of Platelet-Rich Plasma (PRP) in Temporomandibular Disorders: A Clinical Case Series. J Clin Med. 2022 Jul 22;11(15):4281.
9. Harba AN, Harfoush M. Evaluation of the participation of hyaluronic acid with platelet-rich plasma in the treatment of temporomandibular joint disorders. Dent Med Probl. 2021 Jan-Mar;58(1):81-8.
10. Li FL, Wu CB, Sun HJ, Zhou Q. Comparison of Autologous Platelet-Rich Plasma and Chitosan in the Treatment of Temporomandibular Joint Osteoarthritis: A Retrospective Cohort Study. J Oral Maxillofac Surg. 2021 Feb;79(2):324-32.
11. Manafikhi M, Ataya J, Heshmeh O. Evaluation of the efficacy of injectable platelet rich fibrin (I-PRF) in the management of clicking in internal temporomandibular joint disorders. BMC Musculoskeletal Disorders. 2022;23:454-61.
12. Prakash J, Talukder D, Desai K, Singh TK, Bagde R, Randhawa GS, et al. Intra-articular platelet-rich plasma injection versus hydrocortisone with local anesthetic injections for temporo mandibular disorders. Bioinformation. 2022;18(10):920-4.
13. Rajput A, Bansal V, Dubey P, Kapoor A. A Comparative Analysis of Intra-articular Injection of Platelet-Rich Plasma and Arthrocentesis in Temporomandibular Joint Disorders. J Maxillofac Oral Surg. 2022 Mar;21(1):168-75.
14. Karadayi U, Gursoytrak B. Randomised controlled trial of arthrocentesis with or without PRF for internal derangement of the TMJ. J Craniomaxillofac Surg. 2021 May;49(5):362-7.
15. Torul D, Cezairli B, Kahveci K. The efficacy of intra-articular injectable platelet-rich fibrin application in the management of Wilkes stage III temporomandibular joint internal derangement. Int J Oral Maxillofac Surg. 2021 Nov;50(11):1485-90.
16. Singh AK, Sharma NK, Kumar PGN, Singh S, Mishra N, Bera RN. Evaluation of Arthrocentesis with and Without Platelet-Rich Plasma in the Management of Internal Derangement of Temporomandibular Joint: A Randomized Controlled Trial. J Maxillofac Oral Surg. 2021 Jun;20(2):252-7.
17. Sharma P, Aurora JK, Dubey KN, Tandon P, Tiwari S. A comparative analysis between intra articular injections of injectable platelet rich fibrin versus platelet rich plasma in the management of temporomandibular disorders: A randomized control trial. J Maxillofac Surg. 2023;14(2):249-55.
18. Kumar N, Francis M, Sindhu Vk S, Ramachandra V, Anilkumar PV, Fahad Khan M. Efficacy of Injectable Platelet-Rich Fibrin (I-PRF) in Managing Temporomandibular Joint Pain: A Prospective Clinical Study. Cureus. 2024 Feb;16(2):e54367.
19. Vingender S, Dőri F, Schmidt P, Hermann P, Vaszilkó MT. Evaluation of the efficiency of hyaluronic acid, PRP and I-PRF intra-articular injections in the treatment of internal derangement of the temporomandibular joint: A prospective study. J Craniomaxillofac Surg. 2023 Jan;51(1):1-6.
20. De Sousa BM, López-Valverde N, López-Valverde A, Caramelo F, Fraile JF, Payo JH, et al. Different Treatments in Patients with Temporomandibular Joint Disorders: A Comparative Randomized Study. Medicina (Kaunas). 2020 Mar 5;56(3):113.
21. Nitecka-Buchta A, Walczynska-Dragon K, Kempa WM, Baron S. Platelet-Rich Plasma Intramuscular Injections - Antinociceptive Therapy in Myofascial Pain Within Masseter Muscles in Temporomandibular Disorders Patients: A Pilot Study. Front Neurol. 2019;10:250.
22. Elgazzaz MA, Khalifa FA, Amin G, Elsayed SA. The Use Of Injectable Platelet Rich Fibrin In The Treatment Of Tempromandibular Joint Hypermobility. Al-Azhar D J. 2019;6(4):507-15.
23. Gupta S, Sharma AK, Purohit J, Goyal R, Malviya Y, Jain S. Comparison between intra-articular platelet-rich plasma injection versus hydrocortisone with local anesthetic injections in temporomandibular disorders: A double-blind study. Natl J Maxillofac Surg. 2018 Jul-Dec;9(2):205-8.
24. Albilia J, Herrera-Vizcaíno C, Weisleder H, Choukroun J, Ghanaati S. Liquid platelet-rich fibrin injections as a treatment adjunct for painful temporomandibular joints: preliminary results. Cranio. 2020 Sep;38(5):292-304.
25. Lin SL, Tsai CC, Wu SL, Ko SY, Chiang WF, Yang JW. Effect of arthrocentesis plus platelet-rich plasma and platelet-rich plasma alone in the treatment of temporomandibular joint osteoarthritis: A retrospective matched cohort study (A STROBE-compliant article). Medicine (Baltimore). 2018 Apr;97(16):e0477.
26. Hancı M, Karamese M, Tosun Z, Aktan TM, Duman S, Savaci N. Intra-articular platelet-rich plasma injection for the treatment of temporomandibular disorders and a comparison with arthrocentesis. J Craniomaxillofac Surg. 2015 Jan;43(1):162-6.
27. Hegab AF, Ali HE, Elmasry M, Khallaf MG. Platelet-Rich Plasma Injection as an Effective Treatment for Temporomandibular Joint Osteoarthritis. J Oral Maxillofac Surg. 2015 Sep;73(9):1706-13.
28. Yuce E, Komerik N. Comparison of the Efficiacy of Intra-Articular Injection of Liquid Platelet-Rich Fibrin and Hyaluronic Acid After in Conjunction With Arthrocentesis for the Treatment of Internal Temporomandibular Joint Derangements. J Craniofac Surg. 2020 Oct;31(7):1870-4.
29. Schulz S. [Evaluation of periarticular autotransfusion for therapy of recurrent dislocations of the temporomandibular joint]. Dtsch Stomatol. 1973 Feb;23(2):94-8.
30. Jacobi-Hermanns E, Wagner G, Tetsch P. Investigations on recurrent condyle dislocation in patients with temporomandibular joint dysfunction: a therapeutical concept. Int J Oral Surg. 1981;10(Suppl 1):318-23.
31. Hasson O, Nahlieli O. Autologous blood injection for treatment of recurrent temporomandibular joint dislocation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Oct;92(4):390-3.
32. Hjortdal O. [Habitual dislocation of the temporomandibular joint]. Nor Tannlaegeforen Tid. 1975 Feb;85(2):68-72.
33. Kato T, Shimoyama T, Nasu D, Kaneko T, Horie N, Kudo I. Autologous blood injection into the articular cavity for the treatment of recurrent temporomandibular joint dislocation: a case report. J Oral Sci. 2007 Sep;49(3):237-9.
34. Borie E, Oliví DG, Orsi IA, Garlet K, Weber B, Beltrán V, et al. Platelet-rich fibrin application in dentistry: a literature review. Int J Clin Exp Med. 2015;8(5):7922-9.
35. Albanese A, Licata ME, Polizzi B, Campisi G. Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing. 2013 Jun 13;10(1):23.
2. Iturriaga V, Bornhardt T, Velasquez N. Temporomandibular Joint: Review of Anatomy and Clinical Implications. Dent Clin North Am. 2023 Apr;67(2):199-209.
3. Gutiérrez IQ, Sábado-Bundó H, Gay-Escoda C. Intraarticular injections of platelet rich plasma and plasma rich in growth factors with arthrocenthesis or arthroscopy in the treatment of temporomandibular joint disorders: A systematic review. J Stomatol Oral Maxillofac Surg. 2022 Oct;123(5):e327-e35.
4. Haddad C, Zoghbi A, El Skaff E, Touma J. Platelet-rich plasma injections for the treatment of temporomandibular joint disorders: A systematic review. J Oral Rehabil. 2023 Jun 21:1-12.
5. Xu J, Ren H, Zhao S, Li Q, Li C, Bao G, et al. Comparative effectiveness of hyaluronic acid, platelet-rich plasma, and platelet-rich fibrin in treating temporomandibular disorders: a systematic review and network meta-analysis. Head Face Med. 2023 Aug 26;19(1):39.
6. Nemeth A, Gurgel BV, Lowenstein A, Juliasse L, Siroma RS, Zhu Z, et al. Does Liquid/Injectable Platelet-Rich Fibrin Help in the Arthrocentesis Treatment of Temporomandibular Joint Disorder Compared to Other Infusion Options? A Systematic Review of Randomized Clinical Trials. Bioengineering. 2024;11(3):247.
7. Işık G, Kenç S, Özveri Koyuncu B, Günbay S, Günbay T. Injectable platelet-rich fibrin as treatment for temporomandibular joint osteoarthritis: A randomized controlled clinical trial. J Craniomaxillofac Surg. 2022 Jul;50(7):576-82.
8. Sikora M, Sielski M, Chęciński M, Nowak Z, Czerwińska-Niezabitowska B, Chlubek D. Repeated Intra-Articular Administration of Platelet-Rich Plasma (PRP) in Temporomandibular Disorders: A Clinical Case Series. J Clin Med. 2022 Jul 22;11(15):4281.
9. Harba AN, Harfoush M. Evaluation of the participation of hyaluronic acid with platelet-rich plasma in the treatment of temporomandibular joint disorders. Dent Med Probl. 2021 Jan-Mar;58(1):81-8.
10. Li FL, Wu CB, Sun HJ, Zhou Q. Comparison of Autologous Platelet-Rich Plasma and Chitosan in the Treatment of Temporomandibular Joint Osteoarthritis: A Retrospective Cohort Study. J Oral Maxillofac Surg. 2021 Feb;79(2):324-32.
11. Manafikhi M, Ataya J, Heshmeh O. Evaluation of the efficacy of injectable platelet rich fibrin (I-PRF) in the management of clicking in internal temporomandibular joint disorders. BMC Musculoskeletal Disorders. 2022;23:454-61.
12. Prakash J, Talukder D, Desai K, Singh TK, Bagde R, Randhawa GS, et al. Intra-articular platelet-rich plasma injection versus hydrocortisone with local anesthetic injections for temporo mandibular disorders. Bioinformation. 2022;18(10):920-4.
13. Rajput A, Bansal V, Dubey P, Kapoor A. A Comparative Analysis of Intra-articular Injection of Platelet-Rich Plasma and Arthrocentesis in Temporomandibular Joint Disorders. J Maxillofac Oral Surg. 2022 Mar;21(1):168-75.
14. Karadayi U, Gursoytrak B. Randomised controlled trial of arthrocentesis with or without PRF for internal derangement of the TMJ. J Craniomaxillofac Surg. 2021 May;49(5):362-7.
15. Torul D, Cezairli B, Kahveci K. The efficacy of intra-articular injectable platelet-rich fibrin application in the management of Wilkes stage III temporomandibular joint internal derangement. Int J Oral Maxillofac Surg. 2021 Nov;50(11):1485-90.
16. Singh AK, Sharma NK, Kumar PGN, Singh S, Mishra N, Bera RN. Evaluation of Arthrocentesis with and Without Platelet-Rich Plasma in the Management of Internal Derangement of Temporomandibular Joint: A Randomized Controlled Trial. J Maxillofac Oral Surg. 2021 Jun;20(2):252-7.
17. Sharma P, Aurora JK, Dubey KN, Tandon P, Tiwari S. A comparative analysis between intra articular injections of injectable platelet rich fibrin versus platelet rich plasma in the management of temporomandibular disorders: A randomized control trial. J Maxillofac Surg. 2023;14(2):249-55.
18. Kumar N, Francis M, Sindhu Vk S, Ramachandra V, Anilkumar PV, Fahad Khan M. Efficacy of Injectable Platelet-Rich Fibrin (I-PRF) in Managing Temporomandibular Joint Pain: A Prospective Clinical Study. Cureus. 2024 Feb;16(2):e54367.
19. Vingender S, Dőri F, Schmidt P, Hermann P, Vaszilkó MT. Evaluation of the efficiency of hyaluronic acid, PRP and I-PRF intra-articular injections in the treatment of internal derangement of the temporomandibular joint: A prospective study. J Craniomaxillofac Surg. 2023 Jan;51(1):1-6.
20. De Sousa BM, López-Valverde N, López-Valverde A, Caramelo F, Fraile JF, Payo JH, et al. Different Treatments in Patients with Temporomandibular Joint Disorders: A Comparative Randomized Study. Medicina (Kaunas). 2020 Mar 5;56(3):113.
21. Nitecka-Buchta A, Walczynska-Dragon K, Kempa WM, Baron S. Platelet-Rich Plasma Intramuscular Injections - Antinociceptive Therapy in Myofascial Pain Within Masseter Muscles in Temporomandibular Disorders Patients: A Pilot Study. Front Neurol. 2019;10:250.
22. Elgazzaz MA, Khalifa FA, Amin G, Elsayed SA. The Use Of Injectable Platelet Rich Fibrin In The Treatment Of Tempromandibular Joint Hypermobility. Al-Azhar D J. 2019;6(4):507-15.
23. Gupta S, Sharma AK, Purohit J, Goyal R, Malviya Y, Jain S. Comparison between intra-articular platelet-rich plasma injection versus hydrocortisone with local anesthetic injections in temporomandibular disorders: A double-blind study. Natl J Maxillofac Surg. 2018 Jul-Dec;9(2):205-8.
24. Albilia J, Herrera-Vizcaíno C, Weisleder H, Choukroun J, Ghanaati S. Liquid platelet-rich fibrin injections as a treatment adjunct for painful temporomandibular joints: preliminary results. Cranio. 2020 Sep;38(5):292-304.
25. Lin SL, Tsai CC, Wu SL, Ko SY, Chiang WF, Yang JW. Effect of arthrocentesis plus platelet-rich plasma and platelet-rich plasma alone in the treatment of temporomandibular joint osteoarthritis: A retrospective matched cohort study (A STROBE-compliant article). Medicine (Baltimore). 2018 Apr;97(16):e0477.
26. Hancı M, Karamese M, Tosun Z, Aktan TM, Duman S, Savaci N. Intra-articular platelet-rich plasma injection for the treatment of temporomandibular disorders and a comparison with arthrocentesis. J Craniomaxillofac Surg. 2015 Jan;43(1):162-6.
27. Hegab AF, Ali HE, Elmasry M, Khallaf MG. Platelet-Rich Plasma Injection as an Effective Treatment for Temporomandibular Joint Osteoarthritis. J Oral Maxillofac Surg. 2015 Sep;73(9):1706-13.
28. Yuce E, Komerik N. Comparison of the Efficiacy of Intra-Articular Injection of Liquid Platelet-Rich Fibrin and Hyaluronic Acid After in Conjunction With Arthrocentesis for the Treatment of Internal Temporomandibular Joint Derangements. J Craniofac Surg. 2020 Oct;31(7):1870-4.
29. Schulz S. [Evaluation of periarticular autotransfusion for therapy of recurrent dislocations of the temporomandibular joint]. Dtsch Stomatol. 1973 Feb;23(2):94-8.
30. Jacobi-Hermanns E, Wagner G, Tetsch P. Investigations on recurrent condyle dislocation in patients with temporomandibular joint dysfunction: a therapeutical concept. Int J Oral Surg. 1981;10(Suppl 1):318-23.
31. Hasson O, Nahlieli O. Autologous blood injection for treatment of recurrent temporomandibular joint dislocation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Oct;92(4):390-3.
32. Hjortdal O. [Habitual dislocation of the temporomandibular joint]. Nor Tannlaegeforen Tid. 1975 Feb;85(2):68-72.
33. Kato T, Shimoyama T, Nasu D, Kaneko T, Horie N, Kudo I. Autologous blood injection into the articular cavity for the treatment of recurrent temporomandibular joint dislocation: a case report. J Oral Sci. 2007 Sep;49(3):237-9.
34. Borie E, Oliví DG, Orsi IA, Garlet K, Weber B, Beltrán V, et al. Platelet-rich fibrin application in dentistry: a literature review. Int J Clin Exp Med. 2015;8(5):7922-9.
35. Albanese A, Licata ME, Polizzi B, Campisi G. Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing. 2013 Jun 13;10(1):23.
| Files | ||
| Issue | Vol 11, No 4 (Autumn 2024) | |
| Section | Review Article(s) | |
| Keywords | ||
| Blood factors; Temporomandibular disorders; Platelet-rich plasma; Platelet-rich fibrin. | ||
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How to Cite
1.
Ghannadpour A, Honar S, Toumaj A, Mousavi Sangsaraki SP, Razmara F. Efficacy of Blood Factors for Treatment of Temporomandibular Disorders: A Review. J Craniomaxillofac Res. 2025;11(4):195-208.
