Oral Undifferentiated Pleomorphic Sarcoma: A Case Report
,
Abstract
Undifferentiated pleomorphic sarcoma is a common soft tissue sarcoma in the human body, but it is rarely reported in the oral cavity. This article aims to report a case of UPS in the mandible. An 83-year-old female patient was referred to the Department of Oral and Maxillofacial Pathology at the Faculty of Dentistry in Isfahan, Iran, with a complaint of sudden, painless swelling under her removable complete denture, which had grown gradually over three months. The size of the lesion was approximately 5cm, and there were no radiographic defects present. Neoplastic and malignant proliferation of cells, which is necessary for UPS final diagnosis, was present in the H&E microcopy evaluation. Furthermore, immunohistochemical examination proved that the lesion is an undifferentiated pleomorphic sarcoma. Because of the late diagnosis of the disease, the patient died due to lung metastasis before any treatment. Keywords: Case report; Surgery; Undifferentiated pleomorphic sarcoma; Malignant fibrous histiocytoma.
1. Widemann BC, Italiano A. Biology and management of undifferentiated pleomorphic sarcoma, myxofibrosarcoma, and malignant peripheral nerve sheath tumors: state of the art and perspectives. J Clin Oncol 2018; 36(2): 160-7.
2. You Y, Shi R, Dai M, Du Z, Tian Z, Xu G, et al. Primary undifferentiated pleomorphic sarcoma in oral-maxillary area: retrospective study and molecular analysis. Histol Histopathol 2021; 36(8): 889-98.
3. Vivek N, Magesh KT, Sivachandran A, Kumar MS. Undifferentiated pleomorphic sarcoma of maxilla presenting like a periapical pathology – a case report. J NTR Univ Health Sci
2018; 7: 70-3.
4. Shahoon H, Esmaeili M, Nematollahi M. Eight year follow up of malignant fibrous histiocytoma (undifferentiated high grade pleomorphic sarcoma) of the maxilla: case report and review of the literature. J Dent Res Dent Clin Dent Prospects 2009; 3: 32-5.
5. Benites BM, Miranda-Silva W, Fonseca FP, de Oliveira CRGCM, Fregnani ER. Undifferentiated pleomorphic sarcoma of the mandible. J Korean Assoc Oral Maxillofac Surg 2020; 46: 282-7.
6. Kim CH, Jang JW, Kim MY, Kim YH, Kim HG, Kim JH. Undifferentiated pleomorphic sarcoma in mandible. Maxillofac Plast Reconstr Surg 2014; 36(6): 303-7.
7. Archana TS, Shetty A, Imran M, Ahmed N, Kumar P, Shruthi TM. A rare entity of undifferentiated pleomorphic sarcoma of the mandible - a case report. Ann Maxillofac Surg 2021; 11(1): 156-9.
8. Lambade PN, Lambade D, Saha TK, Bande CR, Ramakrishana A. Malignant fibrous histiocytoma: an uncommon sarcoma with pathological fracture of mandible. J Maxillofac Oral Surg 2015; 14: 283-7.
9. Amm HM, DeVilliers P, Srivastava AR, Diniz MG, Siegal GP, MacDougall M. Mandibular undifferentiated pleomorphic sarcoma: Molecular analysis of a primary cell population. Clin Exp Dent Res 2020; 6: 495–505.
10. Chen S, Huang W, Luo P, Cai W, Yang L, Sun Z, et al. Undifferentiated pleomorphic sarcoma: long-term follow-up from a large institution. Cancer Manag Res 2019; 11: 10001-9.
11. Thompson LD. Pleomorphic sarcoma of the neck. Ear Nose Throat J 2015; 94: 376-7.
12. Rajan ST, Elengkumaran S, Narasimhan M, Ravindran C. Pleomorphic sarcoma of the oral cavity: a rare case entity. J Pharm Bioallied Sci 2021;13(Suppl 2): S1747-S1749.
13. O'Neill JP, Bilsky MH, Kraus D. Head and neck sarcomas: epidemiology, pathology, and management. Neurosurg Clin N Am 2013; 24: 67-78.
2. You Y, Shi R, Dai M, Du Z, Tian Z, Xu G, et al. Primary undifferentiated pleomorphic sarcoma in oral-maxillary area: retrospective study and molecular analysis. Histol Histopathol 2021; 36(8): 889-98.
3. Vivek N, Magesh KT, Sivachandran A, Kumar MS. Undifferentiated pleomorphic sarcoma of maxilla presenting like a periapical pathology – a case report. J NTR Univ Health Sci
2018; 7: 70-3.
4. Shahoon H, Esmaeili M, Nematollahi M. Eight year follow up of malignant fibrous histiocytoma (undifferentiated high grade pleomorphic sarcoma) of the maxilla: case report and review of the literature. J Dent Res Dent Clin Dent Prospects 2009; 3: 32-5.
5. Benites BM, Miranda-Silva W, Fonseca FP, de Oliveira CRGCM, Fregnani ER. Undifferentiated pleomorphic sarcoma of the mandible. J Korean Assoc Oral Maxillofac Surg 2020; 46: 282-7.
6. Kim CH, Jang JW, Kim MY, Kim YH, Kim HG, Kim JH. Undifferentiated pleomorphic sarcoma in mandible. Maxillofac Plast Reconstr Surg 2014; 36(6): 303-7.
7. Archana TS, Shetty A, Imran M, Ahmed N, Kumar P, Shruthi TM. A rare entity of undifferentiated pleomorphic sarcoma of the mandible - a case report. Ann Maxillofac Surg 2021; 11(1): 156-9.
8. Lambade PN, Lambade D, Saha TK, Bande CR, Ramakrishana A. Malignant fibrous histiocytoma: an uncommon sarcoma with pathological fracture of mandible. J Maxillofac Oral Surg 2015; 14: 283-7.
9. Amm HM, DeVilliers P, Srivastava AR, Diniz MG, Siegal GP, MacDougall M. Mandibular undifferentiated pleomorphic sarcoma: Molecular analysis of a primary cell population. Clin Exp Dent Res 2020; 6: 495–505.
10. Chen S, Huang W, Luo P, Cai W, Yang L, Sun Z, et al. Undifferentiated pleomorphic sarcoma: long-term follow-up from a large institution. Cancer Manag Res 2019; 11: 10001-9.
11. Thompson LD. Pleomorphic sarcoma of the neck. Ear Nose Throat J 2015; 94: 376-7.
12. Rajan ST, Elengkumaran S, Narasimhan M, Ravindran C. Pleomorphic sarcoma of the oral cavity: a rare case entity. J Pharm Bioallied Sci 2021;13(Suppl 2): S1747-S1749.
13. O'Neill JP, Bilsky MH, Kraus D. Head and neck sarcomas: epidemiology, pathology, and management. Neurosurg Clin N Am 2013; 24: 67-78.
| Files | ||
| Issue | Vol 12, No 2 (Spring 2025) | |
| Section | Case Report(s) | |
| Keywords | ||
| Case report; Surgery; Undifferentiated pleomorphic sarcoma; Malignant fibrous histiocytoma. Case report Surgery Undifferentiated pleomorphic sarcoma; Malignant fibrous histiocytoma. | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Khalesi S, Ghazi MP, Movahedian Attar B, Razavi SM. Oral Undifferentiated Pleomorphic Sarcoma: A Case Report. J Craniomaxillofac Res. 2025;12(2):118-122.
