The Role of Platelet-Rich Products in Soft Tissue Repair after Extraction of Wisdom Teeth: A Review
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Abstract
Introduction: The extraction of the third molar, commonly known as wisdom tooth extraction, is one of the most frequent clinical procedures. This surgery can lead to several postoperative complications such as pain, trismus, swelling, dry socket and damage to soft and hard tissues, significantly impacting the patient’s quality of life. Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) have been proposed as an effective treatment to mitigate these complications and enhance tissue repair. This study aims to review the role of PRP and PRF in soft tissue repair following wisdom tooth extraction between 2015 and 2023. Materials and Methods: This research reviewed the role of PRP and PRF in soft tissue repair after wisdom tooth extraction. Articles from Scopus, PubMed, Elsevier, and SID databases were selected and reviewed based on inclusion and exclusion criteria, focusing on publications from 2015 to 2023. The search was conducted using keywords such as “impacted wisdom teeth,” “soft tissue,” “hard tissue,” “repair,” “PRP” and “PRF.” Results: Nineteen relevant studies were identified, with no studies conducted in 2023. The studies from this period were primarily meta-analyses with varying degrees of relevance to the study topic. The distribution of the studies reviewed is as follows: three studies in 2022, four studies in 2021, three studies in 2020, one study in 2019, one study in 2018, one study in 2017, two studies in 2016, and four studies in 2015. These studies collectively suggest that PRP and PRF are beneficial in reducing postoperative complications and enhancing the repair of soft tissue damaged during wisdom tooth surgery. Conclusion: PRP and PRF effectively reduce postoperative complications and promote the restoration of soft tissues damaged by wisdom tooth extraction. Therefore, in cases of soft tissue damage and periodontal conditions in patients undergoing wisdom tooth surgery, PRP and PRF can be a valuable treatment option for tissue repair. Keywords: Impacted wisdom teeth; Soft tissue; Hard tissue; Repair; Platelet-rich plasma (PRP); Platelet-rich fibrin (PRF).
References
1- Hupp JR, Tucker MR, Ellis E. Contemporary otal and maxillofacial surgery. china, Mosy, 2008, pp, 149-184.
2- Dodson TB, Susarla SM. Impacted wisdom teeth. BMJ Clin Evid 2014; 2014:1302.
3- Candotto V, Oberti L, Gabrione F, Scarano A, Rossi D, Romano M. Complication in third molar extractions. J Biol Regul Homeost Agents 2019;33(3 Suppl 1):169–72.
4- Rakhshan V. Common risk factors for postoperative pain following the extraction of wisdom teeth. Journal of the Korean Association of Oral and Maxillofacial Surgeons. 2015 Apr 1;41(2):59-65.
5- Miloro M. Petersons Principles of Oral and Maxillofacial Surgery. 2th ed. Canada: BC Decker In; 2004. P. 140-2.
6- Hupp JR, Tucker MR, Ellis E. Contemporary oral and maxillofacial surgery. 7th ed. St. Louis, Missouri: Elsevier; 2018. p. 189, 190.
7- Leslie M. Cell biology. Beyond clotting: the powers of platelets. Science 2010; 328(5978): 562-4.
8- Scimeca CL, Bharara M, Fisher TK, Kimbriel H, Armstrong DG. Novel use of platelet-rich plasma to augment curative diabetic foot surgery. J Diabetes Sci Technol 2010; 4(5): 1121-6.
9- Simon D, Manuel S, Geetha V, Naik BR. Potential for osseous regeneration of platelet-rich plasma--a comparative study in mandibular third molar sockets. Indian J Dent Res 20041; 15(4): 133-6.
10- Albanese A, Licata ME, Polizzi B, Campisi G. Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing 2013; 10(1): 23.
11- Marco Antonello Gd, Torres do Couto R, Giongo CC, Corrêa MB, Chagas Júnior OL, et al. Evaluation of the effects of the use of platelet-rich plasma (PRP) on alveolar bone repair following extraction of impacted third molars: prospective study. J Craniomaxillofac Surg 2013; 41(4): e70-5.
12- Ogundipe OK, Ugboko VI, Owotade FJ. Can autologous platelet-rich plasma gel enhance healing after surgical extraction of mandibular third molars? J Oral Maxillofac Surg 2011; 69(9): 2305-10.
13- Rutkowski JL, Johnson DA, Radio NM, Fennell JW. Platelet rich plasma to facilitate wound healing following tooth extraction. J Oral Implantol 2010; 36(1): 11-23.
14- Al-Maawi S, Becker K, Schwarz F, Sader R, Ghanaati S. Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review. International journal of implant dentistry. 2021 Dec;7:1-27.
15- Alrayyes Y, Al-Jasser R. Regenerative potential of platelet Rich Fibrin (PRF) in Socket Preservation in comparison with Conventional Treatment modalities: a systematic review and Meta-analysis. Tissue Engineering and Regenerative Medicine. 2022 Jun;19(3):463-75.
16- Agonas P., Schiavo J.H., Avila-Ortiz G., Palaiologou A., Katsaros T. Plasma rich in growth factors (PRGF) in intraoral bone grafting procedures: a systematic review. J Cran-Maxillo-Fac Surg. 2019;47(3):443–453.
17- Barona-Dorado C., Gonzalez-Regueiro I., Martin-Ares M., Arias-Irimia O., Martinez-Gonzalez J.M. Efficacy of platelet-rich plasma applied to post-extraction retained lower third molar alveoli. A systematic review. Med Oral, Patol Oral Cirugía Bucal. 2014;19(2):142–148.
18- Rengarajoo J, Ngeow WC, Ibrahim NB. The effects of lyophilised platelet-rich plasma in third molar extraction sockets and its surrounding tissues. Journal of Taibah University Medical Sciences. 2022 Apr 1;17(2):289-96.
19- Ahmed I, Hussain F, Naz S, Hassan SG, Channar KA, Shams S. ROLE OF PLATELET RICH PLASMA ON HEALING FOLLOWING SURGICAL EXTRACTION OF TEETH. Journal of Peoples University of Medical & Health Sciences Nawabshah. (JPUMHS). 2021 Mar 31;11(1):118-22.
20- Al-Noaman AS. Platelet-rich plasma in oral and dental surgery: A review. Medical Journal of Babylon. 2021 Apr 1;18(2):59-65.
21- Bhujbal R, Veerabhadrappa SK, Yadav S, Chappi M, Patil V. Evaluation of platelet-rich fibrin and platelet-rich plasma in impacted mandibular third molar extraction socket healing and bone regeneration: A split-mouth comparative study. European Journal of General Dentistry. 2020 May;9(02):96-102.
22- Aftab A, Joshi UK, Patil SK, Hussain E, Bhatnagar S. Efficacy of autologous platelet rich plasma gel in soft and hard tissue healing after surgical extraction of impacted mandibular third molar-A prospective study. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2020 Jul 1;32(4):241-6.
23- Jonathan R. The effect of lyophilized platelet rich plasma in a third molar extraction socket and its surrounding tissues/Jonathan Rengarajoo (Doctoral dissertation, Universiti Malaya).
24- Bhujbal R, Malik NA, Kumar N, Suresh KV, Parkar MI, Jeevan MB. Comparative evaluation of platelet rich plasma in socket healing and bone regeneration after surgical removal of impacted mandibular third molars. Journal of Dental Research, Dental Clinics, Dental Prospects. 2018;12(3):153.
25- Gandevivala A, Sangle A, Shah D, Tejnani A, Sayyed A, Khutwad G, Patel AA. Autologous platelet-rich plasma after third molar surgery. Annals of Maxillofacial Surgery. 2017 Jul 1;7(2):245-9.
26- Doiphode AM, Hegde P, Mahindra U, Kumar SS, Tenglikar PD, Tripathi V. Evaluation of the efficacy of platelet-rich plasma and platelet-rich fibrin in alveolar defects after removal of impacted bilateral mandibular third molars. Journal of International Society of Preventive and Community Dentistry. 2016 Apr 1;6(Suppl 1):S47-52.
27- Dutta SR, Passi D, Singh P, Sharma S, Singh M, Srivastava D. A randomized comparative prospective study of platelet-rich plasma, platelet-rich fibrin, and hydroxyapatite as a graft material for mandibular third molar extraction socket healing. National journal of maxillofacial surgery. 2016 Jan 1;7(1):45-51.
28- Dutta SR, Singh P, Passi D, Patter P. Mandibular third molar extraction wound healing with and without platelet rich plasma: a comparative prospective study. Journal of maxillofacial and oral surgery. 2015; 14:808-15.
29- Yelamali T, Saikrishna D. Role of platelet rich fibrin and platelet rich plasma in wound healing of extracted third molar sockets: a comparative study. Journal of maxillofacial and oral surgery. 2015; 14:410-6.
30- Gawai KT, Sobhana CR. Clinical evaluation of use of platelet rich plasma in bone healing. Journal of maxillofacial and oral surgery. 2015; 14:67-80.
31- Nathani DB, Sequeira J, Rao BS. Comparison of platelet rich plasma and synthetic graft material for bone regeneration after third molar extraction. Annals of maxillofacial surgery. 2015 Jul 1;5(2):213-8.
32- Sargaiyan V, Manas A, Kumar HH, Saravanan MS, Ghiaz K, Deepalakshmi S. The role of prp in third molar extraction wounds: A clinical study. Journal of Pharmacy and Bioallied Sciences. 2022 Jul 1;14(Suppl 1): S855-8.
33- Osagie O, Saheeb BD, Egbor EP. Evaluation of the Efficacy of Platelet-Rich Plasma versus Platelet-Rich Fibrin in Alleviating Postoperative Inflammatory Morbidities after Lower Third Molar Surgery: A Double-Blind Randomized Study. West African Journal of Medicine. 2022 Apr 1;39(4):343-9.
34- Verma VK, Sublok K, Kushwaha AK, Patra D, Khare A, Singh J. A prospective study to evaluate post operative clinical parameters of platelet rich fibrin and platelet rich plasma in third molar extraction sockets: An original research study. Journal of Advanced Medical and Dental Sciences Research. 2021;9(1):45-50.
35- GIANNINI, S., et al. Comparison between PRP, PRGF and PRF: lights and shadows in three similar but different protocols. Eur Rev Med Pharmacol Sci, 2015, 19.6: 927-30.
36- Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three-dimensional architecture and cell composition of a Choukroun’s platelet-rich fibrin clot and membrane. Journal of periodontology. 2010;42(55):62.
37- Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 6112;010(3): e20–2.
38- Hoaglin DR, Lines GK. Prevention of localized osteitis in mandibular third-molar sites using plateletrich fibrin. International journal of dentistry. 6103;61033062301
39- Hanif M, Sheikh MA. Efficacy of platelet rich plasma (PRP) on mouth opening and pain after surgical extraction of mandibular third molars. Journal of Oral Medicine and Oral Surgery. 2021;27(1):9.
40- Kumar A, Singh G, Gaur A, Kumar S, Numan M, Jacob G, Kiran K. Role of platelet-rich plasma in the healing of impacted third molar socket: a comparative study on central India population. J Contemp Dent Pract. 2020 Sep 1;21(9):986-91.
1- Hupp JR, Tucker MR, Ellis E. Contemporary otal and maxillofacial surgery. china, Mosy, 2008, pp, 149-184.
2- Dodson TB, Susarla SM. Impacted wisdom teeth. BMJ Clin Evid 2014; 2014:1302.
3- Candotto V, Oberti L, Gabrione F, Scarano A, Rossi D, Romano M. Complication in third molar extractions. J Biol Regul Homeost Agents 2019;33(3 Suppl 1):169–72.
4- Rakhshan V. Common risk factors for postoperative pain following the extraction of wisdom teeth. Journal of the Korean Association of Oral and Maxillofacial Surgeons. 2015 Apr 1;41(2):59-65.
5- Miloro M. Petersons Principles of Oral and Maxillofacial Surgery. 2th ed. Canada: BC Decker In; 2004. P. 140-2.
6- Hupp JR, Tucker MR, Ellis E. Contemporary oral and maxillofacial surgery. 7th ed. St. Louis, Missouri: Elsevier; 2018. p. 189, 190.
7- Leslie M. Cell biology. Beyond clotting: the powers of platelets. Science 2010; 328(5978): 562-4.
8- Scimeca CL, Bharara M, Fisher TK, Kimbriel H, Armstrong DG. Novel use of platelet-rich plasma to augment curative diabetic foot surgery. J Diabetes Sci Technol 2010; 4(5): 1121-6.
9- Simon D, Manuel S, Geetha V, Naik BR. Potential for osseous regeneration of platelet-rich plasma--a comparative study in mandibular third molar sockets. Indian J Dent Res 20041; 15(4): 133-6.
10- Albanese A, Licata ME, Polizzi B, Campisi G. Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing 2013; 10(1): 23.
11- Marco Antonello Gd, Torres do Couto R, Giongo CC, Corrêa MB, Chagas Júnior OL, et al. Evaluation of the effects of the use of platelet-rich plasma (PRP) on alveolar bone repair following extraction of impacted third molars: prospective study. J Craniomaxillofac Surg 2013; 41(4): e70-5.
12- Ogundipe OK, Ugboko VI, Owotade FJ. Can autologous platelet-rich plasma gel enhance healing after surgical extraction of mandibular third molars? J Oral Maxillofac Surg 2011; 69(9): 2305-10.
13- Rutkowski JL, Johnson DA, Radio NM, Fennell JW. Platelet rich plasma to facilitate wound healing following tooth extraction. J Oral Implantol 2010; 36(1): 11-23.
14- Al-Maawi S, Becker K, Schwarz F, Sader R, Ghanaati S. Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review. International journal of implant dentistry. 2021 Dec;7:1-27.
15- Alrayyes Y, Al-Jasser R. Regenerative potential of platelet Rich Fibrin (PRF) in Socket Preservation in comparison with Conventional Treatment modalities: a systematic review and Meta-analysis. Tissue Engineering and Regenerative Medicine. 2022 Jun;19(3):463-75.
16- Agonas P., Schiavo J.H., Avila-Ortiz G., Palaiologou A., Katsaros T. Plasma rich in growth factors (PRGF) in intraoral bone grafting procedures: a systematic review. J Cran-Maxillo-Fac Surg. 2019;47(3):443–453.
17- Barona-Dorado C., Gonzalez-Regueiro I., Martin-Ares M., Arias-Irimia O., Martinez-Gonzalez J.M. Efficacy of platelet-rich plasma applied to post-extraction retained lower third molar alveoli. A systematic review. Med Oral, Patol Oral Cirugía Bucal. 2014;19(2):142–148.
18- Rengarajoo J, Ngeow WC, Ibrahim NB. The effects of lyophilised platelet-rich plasma in third molar extraction sockets and its surrounding tissues. Journal of Taibah University Medical Sciences. 2022 Apr 1;17(2):289-96.
19- Ahmed I, Hussain F, Naz S, Hassan SG, Channar KA, Shams S. ROLE OF PLATELET RICH PLASMA ON HEALING FOLLOWING SURGICAL EXTRACTION OF TEETH. Journal of Peoples University of Medical & Health Sciences Nawabshah. (JPUMHS). 2021 Mar 31;11(1):118-22.
20- Al-Noaman AS. Platelet-rich plasma in oral and dental surgery: A review. Medical Journal of Babylon. 2021 Apr 1;18(2):59-65.
21- Bhujbal R, Veerabhadrappa SK, Yadav S, Chappi M, Patil V. Evaluation of platelet-rich fibrin and platelet-rich plasma in impacted mandibular third molar extraction socket healing and bone regeneration: A split-mouth comparative study. European Journal of General Dentistry. 2020 May;9(02):96-102.
22- Aftab A, Joshi UK, Patil SK, Hussain E, Bhatnagar S. Efficacy of autologous platelet rich plasma gel in soft and hard tissue healing after surgical extraction of impacted mandibular third molar-A prospective study. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2020 Jul 1;32(4):241-6.
23- Jonathan R. The effect of lyophilized platelet rich plasma in a third molar extraction socket and its surrounding tissues/Jonathan Rengarajoo (Doctoral dissertation, Universiti Malaya).
24- Bhujbal R, Malik NA, Kumar N, Suresh KV, Parkar MI, Jeevan MB. Comparative evaluation of platelet rich plasma in socket healing and bone regeneration after surgical removal of impacted mandibular third molars. Journal of Dental Research, Dental Clinics, Dental Prospects. 2018;12(3):153.
25- Gandevivala A, Sangle A, Shah D, Tejnani A, Sayyed A, Khutwad G, Patel AA. Autologous platelet-rich plasma after third molar surgery. Annals of Maxillofacial Surgery. 2017 Jul 1;7(2):245-9.
26- Doiphode AM, Hegde P, Mahindra U, Kumar SS, Tenglikar PD, Tripathi V. Evaluation of the efficacy of platelet-rich plasma and platelet-rich fibrin in alveolar defects after removal of impacted bilateral mandibular third molars. Journal of International Society of Preventive and Community Dentistry. 2016 Apr 1;6(Suppl 1):S47-52.
27- Dutta SR, Passi D, Singh P, Sharma S, Singh M, Srivastava D. A randomized comparative prospective study of platelet-rich plasma, platelet-rich fibrin, and hydroxyapatite as a graft material for mandibular third molar extraction socket healing. National journal of maxillofacial surgery. 2016 Jan 1;7(1):45-51.
28- Dutta SR, Singh P, Passi D, Patter P. Mandibular third molar extraction wound healing with and without platelet rich plasma: a comparative prospective study. Journal of maxillofacial and oral surgery. 2015; 14:808-15.
29- Yelamali T, Saikrishna D. Role of platelet rich fibrin and platelet rich plasma in wound healing of extracted third molar sockets: a comparative study. Journal of maxillofacial and oral surgery. 2015; 14:410-6.
30- Gawai KT, Sobhana CR. Clinical evaluation of use of platelet rich plasma in bone healing. Journal of maxillofacial and oral surgery. 2015; 14:67-80.
31- Nathani DB, Sequeira J, Rao BS. Comparison of platelet rich plasma and synthetic graft material for bone regeneration after third molar extraction. Annals of maxillofacial surgery. 2015 Jul 1;5(2):213-8.
32- Sargaiyan V, Manas A, Kumar HH, Saravanan MS, Ghiaz K, Deepalakshmi S. The role of prp in third molar extraction wounds: A clinical study. Journal of Pharmacy and Bioallied Sciences. 2022 Jul 1;14(Suppl 1): S855-8.
33- Osagie O, Saheeb BD, Egbor EP. Evaluation of the Efficacy of Platelet-Rich Plasma versus Platelet-Rich Fibrin in Alleviating Postoperative Inflammatory Morbidities after Lower Third Molar Surgery: A Double-Blind Randomized Study. West African Journal of Medicine. 2022 Apr 1;39(4):343-9.
34- Verma VK, Sublok K, Kushwaha AK, Patra D, Khare A, Singh J. A prospective study to evaluate post operative clinical parameters of platelet rich fibrin and platelet rich plasma in third molar extraction sockets: An original research study. Journal of Advanced Medical and Dental Sciences Research. 2021;9(1):45-50.
35- GIANNINI, S., et al. Comparison between PRP, PRGF and PRF: lights and shadows in three similar but different protocols. Eur Rev Med Pharmacol Sci, 2015, 19.6: 927-30.
36- Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three-dimensional architecture and cell composition of a Choukroun’s platelet-rich fibrin clot and membrane. Journal of periodontology. 2010;42(55):62.
37- Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 6112;010(3): e20–2.
38- Hoaglin DR, Lines GK. Prevention of localized osteitis in mandibular third-molar sites using plateletrich fibrin. International journal of dentistry. 6103;61033062301
39- Hanif M, Sheikh MA. Efficacy of platelet rich plasma (PRP) on mouth opening and pain after surgical extraction of mandibular third molars. Journal of Oral Medicine and Oral Surgery. 2021;27(1):9.
40- Kumar A, Singh G, Gaur A, Kumar S, Numan M, Jacob G, Kiran K. Role of platelet-rich plasma in the healing of impacted third molar socket: a comparative study on central India population. J Contemp Dent Pract. 2020 Sep 1;21(9):986-91.
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| Issue | Vol 12, No 1 (Winter 2025) | |
| Section | Review Article(s) | |
| Keywords | ||
| Impacted wisdom teeth; Soft tissue; Hard tissue; Repair; Platelet-rich plasma (PRP); Platelet-rich fibrin (PRF). | ||
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How to Cite
1.
Bolandparva F, Malekhosseini N, Asgarzade A. The Role of Platelet-Rich Products in Soft Tissue Repair after Extraction of Wisdom Teeth: A Review. J Craniomaxillofac Res. 2025;12(1):1-6.
