Clinicopathologic Study on Odontogenic Tumors-A 10-Year Single Institute Experience
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Abstract
Introduction: Odontogenic tumors are the expansile group of jaw neoplasm that originates from the tooth-forming tissues. WHO, revised classification several times due to their discrete histological and biological behavior. They were broadly classified as benign and malignant tumors, the former being the most common. Benign tumors are classified into epithelial, mixed (epithelial and mesenchymal), and mesenchymal lesions based on their histogenetic origin. Materials and Methods: 1. To evaluate the various types of odontogenic tumors diagnosed in the Department of Oral Pathology. 2. To correlate the clinical data and histological features of odontogenic tumors diagnosed. Clinical data of all the odontogenic tumors were collected retrospectively from the 10-year archives of the Oral Pathology Department, GITAM Dental College and Hospital, Visakhapatnam. The tumors were classified according to the WHO classification. Clinical and histopathological evaluations wasere doneperformed for all the odontogenic tumors. Different histological characteristics were compared; tabulated and analyzed.Results: A total of 105 cases of odontogenic tumors were recorded. 82% account for benign tumors, and 18% for malignant tumors. Epithelial origins comprise the majority of benign tumors (48%), followed by mesenchymal and mixed odontogenic tumors (20% and 14%, respectively). Unicystic ameloblastoma is the most common odontogenic tumor, accounting for 18 (17%) cases, followed by conventional ameloblastoma, odontogenic fibroma, ameloblastic carcinoma, and odontoma. Odontogenic tumors were reported mostly during the second, third, and fourth decades of life. Male predilection was observed over females in all the odontogenic tumors. All forms of OT were detected in the posterior mandible. Epithelial odontogenic tumors predominate in all four anatomical sites, except the posterior maxilla, where mesenchymal OT was somewhat more common and no malignant odontogenic tumor was seen. Conclusion: The variability in data from this study can be ascribed to a variety of demographic factors. Hence, the need to incorporate specific lesion histopathology and diagnostic molecular interventions would make results more sensitive catering to research needs. Keywords: WHO Classification; Odontogenic; Tumors; Ameloblastoma; Odontoma.
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9. Chandrakala J, Sahana NS, Suganya G, Tahasildar J, Jose M, Murugesh J, Renuga S, Verghese R.Prevalence of Odontogenic Tumours: A Study of 122 Cases among Karnataka PopulationJ Clin of Diagn Res.2023; 17(1):ZC05-ZC10.
10. Mehra G, Sanwelka M, Mehra M. Prevalence of odontogenic tumors: A retrospective study of an institute of Rajasthan. IP J Diagn Pathol Oncol 2023;8(3):141-145.
11. Jaya Singh, Shruti Singh, Shaleen Chandra, Fahad M. Samadi. Prevalence and Distribution of Odontogenic Cysts and Tumors in North Indian Population: A Database Study with Systematic Review. International Journal of Applied Biology and Pharmaceutical Technology 11 (2020): 46-59.
12. Torabi M, Khosrozamiri M, Hashemipour MA. Epidemiological and clinicopathological analysis of odontogenic tumors: A 20-year study. Pesqui Bras Odontopediatria Clín Integr. 2024; 24:e200113.
13. Silveira FM, Carneiro Soares Macedo C, Vieira Borges CM, et al. Odontogenic tumors: An 11-year international multicenter study. Oral Dis. 2020;00:1–5.
14. Sharma PN, Ranka RK, Chaudhary MS, Gawande MN, Hande AH, Zade PF. Odontogenic tumors: A review of 93 cases in the Vidharba region of Maharashtra. J Oral Maxillofac Pathol 2020;24:185.
15. Leena Al-aroomy, Mona Wali, Mohamed Alwadeai, Eman El Desouky, Hatem Amer. Odontogenic tumors: A Retrospective Study in Egyptian population using WHO 2017 classification. Med Oral Patol Oral Cir Bucal. 2022 May 1;27 (3):e198-204.
16. Jaya Singh, Shruti Singh, Shaleen Chandra, Fahad M. Samadi. Prevalence and Distribution of Odontogenic Cysts and Tumors in North Indian Population: A Database Study with Systematic Review. International Journal of Applied Biology and Pharmaceutical Technology 11 (2020): 46-59.
2. Brad W. Neville, Carl M. Allen, Douglas D. Damm, Angela C. Chi, Oral and Maxillofacial Pathology, 4th edition, Elsevier.
3. Wright JM, Odell EW, Speight PM, Takata T. Odontogenic tumors, WHO 2005: where do we go from here? Head Neck Pathol. 2014 Dec;8(4):373-82.
4. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. WHO Classification of Head and Neck Tumors 4th Edition. 2017:206-207.
5. Wright JM, Soluk Tekkesin M. Odontogenic tumors. Where are we in 2017? J Istanb Univ Fac Dent 2017;51(3 Suppl 1): S10-S30.
6. Soluk-Tekkesin M, Wright JM. The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2022 (5th) Edition. Turk Patoloji Derg. 2022;38(2):168-184
7. Kokubun K, Yamamoto K, Nakajima K, et al. Frequency of Odontogenic Tumors: A Single Center Study of 1089 Cases in Japan and Literature Review. Head Neck Pathol. 2022;16(2):494-502.
8. Soluk-Tekkesin M, Wright JM. The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2022 (5th) Edition. Turk Patoloji Derg. 2022;38(2):168-184.
9. Chandrakala J, Sahana NS, Suganya G, Tahasildar J, Jose M, Murugesh J, Renuga S, Verghese R.Prevalence of Odontogenic Tumours: A Study of 122 Cases among Karnataka PopulationJ Clin of Diagn Res.2023; 17(1):ZC05-ZC10.
10. Mehra G, Sanwelka M, Mehra M. Prevalence of odontogenic tumors: A retrospective study of an institute of Rajasthan. IP J Diagn Pathol Oncol 2023;8(3):141-145.
11. Jaya Singh, Shruti Singh, Shaleen Chandra, Fahad M. Samadi. Prevalence and Distribution of Odontogenic Cysts and Tumors in North Indian Population: A Database Study with Systematic Review. International Journal of Applied Biology and Pharmaceutical Technology 11 (2020): 46-59.
12. Torabi M, Khosrozamiri M, Hashemipour MA. Epidemiological and clinicopathological analysis of odontogenic tumors: A 20-year study. Pesqui Bras Odontopediatria Clín Integr. 2024; 24:e200113.
13. Silveira FM, Carneiro Soares Macedo C, Vieira Borges CM, et al. Odontogenic tumors: An 11-year international multicenter study. Oral Dis. 2020;00:1–5.
14. Sharma PN, Ranka RK, Chaudhary MS, Gawande MN, Hande AH, Zade PF. Odontogenic tumors: A review of 93 cases in the Vidharba region of Maharashtra. J Oral Maxillofac Pathol 2020;24:185.
15. Leena Al-aroomy, Mona Wali, Mohamed Alwadeai, Eman El Desouky, Hatem Amer. Odontogenic tumors: A Retrospective Study in Egyptian population using WHO 2017 classification. Med Oral Patol Oral Cir Bucal. 2022 May 1;27 (3):e198-204.
16. Jaya Singh, Shruti Singh, Shaleen Chandra, Fahad M. Samadi. Prevalence and Distribution of Odontogenic Cysts and Tumors in North Indian Population: A Database Study with Systematic Review. International Journal of Applied Biology and Pharmaceutical Technology 11 (2020): 46-59.
| Files | ||
| Issue | Vol 12, No 1 (Winter 2025) | |
| Section | Original Article(s) | |
| Keywords | ||
| WHO Classification; Odontogenic; Tumors; Ameloblastoma; Odontoma. | ||
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How to Cite
1.
Sreevalli U, Uppala D, Harika Varshita B. Clinicopathologic Study on Odontogenic Tumors-A 10-Year Single Institute Experience. J Craniomaxillofac Res. 2025;12(1):17-25.
